INT45717

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 3.22
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 12
plasma 1
Yif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 11 89.60 High High
anesthesia 2 77.92 Quite High
Paracetamol 11 51.56 Quite High
carbamazepine 22 40.96 Quite Low
antiepileptic Drug 11 38.48 Quite Low
member 8 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 77 99.24 Very High Very High Very High
Adverse Drug Reaction 33 98.96 Very High Very High Very High
Disease 44 98.60 Very High Very High Very High
Injury 39 98.60 Very High Very High Very High
Aging 242 98.14 Very High Very High Very High
Disease Progression 11 93.20 High High
Hyperplasia 11 90.28 High High
Stress 77 87.32 High High
Liver Cell Adenoma 11 81.68 Quite High
Body Weight 22 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amino acid infusions in the injured animals further increased the synthesis of liver protein (from 36.6% to 44.3%/day, p less than 0.05) and increased muscle protein synthesis (from 7.0% to 9.3%/day, p less than 0.05) without altering rates of protein breakdown.
Gene_expression (synthesis) of liver protein in liver
1) Confidence 0.52 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 6766528 Disease Relevance 0.16 Pain Relevance 0.08
The usual increases in liver protein synthesis observed in fasted rats following injury were not seen when the animals were receiving intravenous glucose.
Gene_expression (synthesis) of liver protein in liver associated with injury
2) Confidence 0.52 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 6766528 Disease Relevance 0.26 Pain Relevance 0.06
Age and sex dependent changes in liver gene expression during the life cycle of the rat

Background

Gene_expression (expression) of liver gene in liver
3) Confidence 0.01 Published 2010 Journal BMC Genomics Section Title Doc Link PMC3012673 Disease Relevance 0.55 Pain Relevance 0
This study provides a comprehensive look at liver gene expression in untreated male and female rats throughout the entire life cycle in order to assess the basal level profiles of liver genes that may underlie patterns of susceptibility due to sex and age.


Gene_expression (expression) of liver gene in liver
4) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.54 Pain Relevance 0
This study comprises one of the most comprehensive data sets to date for rodent liver gene expression with regards to sex, life span, biological replication, and genome coverage.
Gene_expression (expression) of liver gene in liver
5) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.08 Pain Relevance 0
However, a more comprehensive evaluation of the whole genome during time points spanning immature, pubertal, early adult and aging adult animals, in both sexes, would provide greater interpretive power to assess life cycle liver gene expression and its impact on drug safety and disease.
Gene_expression (expression) of liver gene in liver associated with toxicity, aging and disease
6) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.55 Pain Relevance 0.05
Whole genome profiling of rat liver gene expression was performed (n = 5) in each sex and age group using Agilent microarrays.
Gene_expression (expression) of liver gene in liver
7) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.23 Pain Relevance 0.04
The major mechanisms controlling sex differences in liver gene expression have been well-characterized [52] and are dictated by the distinct patterns of continuous vs. pulsatile plasma growth hormone (GH) secretion in females and males, respectively [53].
Gene_expression (expression) of liver gene in plasma
8) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Furthermore, such a comprehensive picture of life cycle changes in gene expression deepens our understanding and informs the utility of liver gene expression biomarkers.



Gene_expression (expression) of liver gene in liver
9) Confidence 0.01 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC3012673 Disease Relevance 0.17 Pain Relevance 0
Wauthier et al [22] provide comprehensive lists of male- and female-specific liver gene expression in approximately 13 week old rats.
Gene_expression (expression) of liver gene in liver
10) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Previous studies of rat liver gene expression have also shown age-related changes in xenobiotic metabolism genes, although only male rats were examined, [17] and included Cyp2c11 and Cyp3a2.
Gene_expression (expression) of liver gene in liver
11) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Understanding the basal liver gene expression patterns is a necessary first step in addressing this hypothesis and will inform our assessments of adverse drug reactions as the liver plays a central role in drug metabolism and biotransformation.
Gene_expression (expression) of liver gene in liver associated with adverse drug reaction
12) Confidence 0.01 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC3012673 Disease Relevance 0.56 Pain Relevance 0
The composite liver gene expression profiles for all genes (unfiltered) displayed good reproducibility in general between animals of the same sex and age group with average Pearson's correlations of R = 0.986 between biological replicates of the same sex and age.
Gene_expression (expression) of liver gene in liver
13) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.13 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox