INT45719

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.68
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
somatotroph 4
pituitary 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 12 100.00 Very High Very High Very High
dexamethasone 8 100.00 Very High Very High Very High
anesthesia 2 99.68 Very High Very High Very High
Somatostatin 4 91.96 High High
antagonist 1 91.28 High High
dopamine receptor 1 90.84 High High
agonist 6 90.68 High High
Neurotransmitter 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Adenoma 2 93.64 High High
Cancer 2 92.80 High High
Cushing's Syndrome /

Hypercortisolism

10 86.48 High High
Prolactinoma 2 85.64 High High
Galactorrhea 1 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 micrograms/l).
Positive_regulation (after) of Transcription (observed) of GH associated with dexamethasone and clonidine
1) Confidence 0.47 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.52
Glucocorticoids (GCs) play a key role in the physiology of the hypothalamic-somatotroph axis, since these steroids enhance growth hormone (GH) gene transcription and increase GHRH receptor synthesis.
Positive_regulation (enhance) of Transcription (transcription) of GH in somatotroph
2) Confidence 0.28 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Glucocorticoids (GCs) play a key role in the physiology of the hypothalamic-somatotroph axis, since these steroids enhance growth hormone (GH) gene transcription and increase GHRH receptor synthesis.
Positive_regulation (enhance) of Transcription (transcription) of enhance growth hormone in somatotroph
3) Confidence 0.24 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Bromocriptine enhanced GH mRNA content and potentiated the GHRH (10(-8) M)-stimulated content of GH mRNA, while CLON had no effect on GH mRNA.
Positive_regulation (enhanced) of Transcription (content) of GH associated with clonidine
4) Confidence 0.23 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.78
Other pituitary hormones, with the exception of GH, which increased during anesthesia and operation, exhibited no acute changes.
Positive_regulation (increased) of Neg (exception) Transcription (exception) of GH in pituitary associated with anesthesia
5) Confidence 0.06 Published 1980 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6766667 Disease Relevance 0.51 Pain Relevance 0.29

General Comments

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