INT45722

Context Info Confidence 0.56 First Reported 1980 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.43 Pain Relevance 0.78

extracellular space (CFHR1) extracellular region (CFHR1)

Anatomy Link Frequency forelimb 1 CFHR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 4 99.40 narcan 7 87.16 Dismenorea 1 83.48 Opioid 2 79.76 antagonist 1 62.80 algil 4 50.00 adenocard 3 5.00 Inflammation 3 5.00 cva 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Age-related Macular Degeneration 65 98.16 Stress 4 94.16 Dysmenorrhea 1 83.48 Recurrence 3 77.88 Disease 64 77.44 Ocular Toxicity (including Many Sub-types) 14 75.92 Genetic Predisposition To Disease 1 75.28 Asphyxia 1 75.00 Nicotine Addiction 2 55.60 Hemolytic Uremic Syndrome 14 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Morphine administration significantly decreased FHR, but it increased FHR variation and forelimb movements (LM).

Negative_regulation (decreased) of FHR in forelimb associated with morphine

1) Confidence 0.56 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11247963 Disease Relevance 0 Pain Relevance 0.70

We hypothesised that the crossover responsible for deletion of CFHL1 could also potentially result in formation of a CFH/CFHL1 hybrid gene.

Negative_regulation (deletion) of CFHL1

2) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.23 Pain Relevance 0

In spite of the decrease of FHR, no fetal distress occurred.

Negative_regulation (decrease) of FHR

3) Confidence 0.41 Published 1998 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 10806695 Disease Relevance 0 Pain Relevance 0

RESULTS: The baseline FHR showed a decrease 30 minutes after dolantin, and decreased further at 1 and 2 hours though still within normal range.

Negative_regulation (decreased) of FHR

4) Confidence 0.36 Published 1998 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 10806695 Disease Relevance 0 Pain Relevance 0

Interestingly, a CFH haplotype with a deletion in CFHR1 and CFHR3 elicits an independent decreased risk of AMD [113].

Negative_regulation (deletion) of CFHR1 associated with age-related macular degeneration

5) Confidence 0.31 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.05 Pain Relevance 0

It is concluded that, under the conditions described, an unequivocal decrease in mean FHR signals a substantial reduction in the availability of O2 to the fetus.

Negative_regulation (decrease) of FHR

6) Confidence 0.03 Published 1980 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6768296 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

This test has worked.