INT45725

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.61
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia3) endoplasmic reticulum (Pdia3)
Anatomy Link Frequency
liver 1
kidney 1
reticulum 1
Pdia3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 43 100.00 Very High Very High Very High
spinal inflammation 6 98.10 Very High Very High Very High
methadone 7 95.00 High High
fortral 3 83.76 Quite High
tolerance 3 79.04 Quite High
bradykinin 1 64.00 Quite High
midbrain 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloidosis 14 100.00 Very High Very High Very High
Disease 12 100.00 Very High Very High Very High
Thyroiditis 6 99.76 Very High Very High Very High
Low Back Pain 6 98.10 Very High Very High Very High
Toxicity 11 97.88 Very High Very High Very High
Alzheimer's Dementia 2 91.04 High High
Necrosis 4 87.60 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 86.64 High High
Lichen 4 75.00 Quite High
Hepatotoxicity 2 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for common binding of acetaminophen and bromobenzene to the 58-kDa acetaminophen-binding protein.
58-kDa Binding (binding) of associated with paracetamol
1) Confidence 0.47 Published 1995 Journal J Toxicol Environ Health Section Title Doc Link 7473856 Disease Relevance 0.10 Pain Relevance 0.76
RibCys cotreatment decreased covalent binding to the 58-kDa acetaminophen-binding protein in both liver and kidney.
58-kDa Binding (binding) of in kidney associated with paracetamol
2) Confidence 0.47 Published 2000 Journal Toxicol Pathol Section Abstract Doc Link 11026606 Disease Relevance 0.56 Pain Relevance 1.29
In addition, the association of PLCA with autoimmune thyroiditis has not been previously reported.
PLCA Binding (association) of associated with thyroiditis and amyloidosis
3) Confidence 0.38 Published 2000 Journal J Eur Acad Dermatol Venereol Section Abstract Doc Link 10972101 Disease Relevance 1.15 Pain Relevance 0.26
Although ankylosing spondylitis may be associated with secondary systemic amyloidosis, no reports have been found showing the association of this disease with PLCA.
PLCA Binding (association) of associated with spinal inflammation, amyloidosis and disease
4) Confidence 0.38 Published 2000 Journal J Eur Acad Dermatol Venereol Section Abstract Doc Link 10972101 Disease Relevance 1.16 Pain Relevance 0.26
This Ppi family exhibits generally low levels of expression with exceptions being Pdia1, Pdia3, Pdia6, Ppia, Ppib, and Ppic.
Pdia3 Neg (exceptions) Binding (exceptions) of
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.09 Pain Relevance 0
RibCys cotreatment decreased covalent binding to the 58-kDa acetaminophen-binding protein in both liver and kidney.
58-kDa Binding (binding) of in liver associated with paracetamol
6) Confidence 0.16 Published 2000 Journal Toxicol Pathol Section Abstract Doc Link 11026606 Disease Relevance 0.56 Pain Relevance 1.29
Cytochrome P-450 content, when expressed per milligram of microsomal protein, was elevated as early as day 1 of administration.
microsomal protein Binding (milligram) of
7) Confidence 0.06 Published 1980 Journal Drug Alcohol Depend Section Abstract Doc Link 6768537 Disease Relevance 0 Pain Relevance 0.46
The sigma(1)-receptor is a one-transmembrane endoplasmic reticulum protein that binds neurosteroids and dextrorotatory benzomorphans.
endoplasmic reticulum protein Binding (binds) of in reticulum
8) Confidence 0.04 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10869377 Disease Relevance 0 Pain Relevance 0.12

General Comments

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