INT45753

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Context Info
Confidence 0.79
First Reported 1980
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 32.31
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
platelets 4
plasma 3
B cells 3
lymph nodes 1
spleen 1
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 5 99.12 Very High Very High Very High
chemokine 45 98.72 Very High Very High Very High
spastic colon 2 98.48 Very High Very High Very High
cytokine 192 98.12 Very High Very High Very High
Pain 57 97.96 Very High Very High Very High
Arthritis 299 97.82 Very High Very High Very High
rheumatoid arthritis 173 97.56 Very High Very High Very High
Inflammatory marker 12 96.36 Very High Very High Very High
abdominal pain 4 91.08 High High
Inflammation 169 89.32 High High
Disease Link Frequency Relevance Heat
Hepatitis 18 100.00 Very High Very High Very High
Myocardial Infarction 402 99.88 Very High Very High Very High
Infection 294 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 99.84 Very High Very High Very High
Influenza Virus Infection 69 99.80 Very High Very High Very High
Systemic Sclerosis 68 99.80 Very High Very High Very High
Malignant Neoplastic Disease 20 99.76 Very High Very High Very High
Epstein-barr Virus 15 99.76 Very High Very High Very High
Fever 154 99.18 Very High Very High Very High
Macroglobulinemia 23 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data in humans and animals suggest that the spleen may facilitate IgM secretion by normal and malignant B lymphocytes.
Localization (secretion) of IgM in B lymphocytes associated with malignant neoplastic disease
1) Confidence 0.79 Published 1995 Journal Am. J. Hematol. Section Abstract Doc Link 7717376 Disease Relevance 0.68 Pain Relevance 0.08
Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course.
Localization (secreting) of IgM in spleen associated with macroglobulinemia and malignant neoplastic disease
2) Confidence 0.78 Published 1980 Journal Am. J. Hematol. Section Abstract Doc Link 6776807 Disease Relevance 0.75 Pain Relevance 0
A soluble CD40 ligand (sCD40L) is released from the activated T cells and platelets by ill-defined proteolytic process in vitro.
Localization (released) of CD40 ligand in platelets
3) Confidence 0.78 Published 2005 Journal Eur. J. Haematol. Section Abstract Doc Link 15613107 Disease Relevance 0.25 Pain Relevance 0.08
Patients with other non-dengue febrile illnesses (OFI) were defined by febrile illness with no detectable DEN-specific IgM, no detectable DEN RNA, and no obvious or reported bacterial etiology for their illness during the same study period.
Neg (no) Localization (etiology) of IgM associated with dengue and fever
4) Confidence 0.73 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.68 Pain Relevance 0.07
Moreover, the anti-MCV decrease was related to the DAS28 response after 12 months, which is not the case for IgM-RF as their decrease is significant in responder as well as nonresponder RA patients.
Localization (case) of IgM associated with rheumatoid arthritis
5) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656247 Disease Relevance 0.45 Pain Relevance 0.43
Patients were assessed on admission: clinical characteristics, ECG (electrocardiogram), renal function, cardiac troponin T (cTnT), heart fatty acid binding protein (H-FABP), glycogen phosphorylase-BB, NT-pro-brain natriuretic peptide, D-dimer, hsCRP (high sensitivity C-reactive protein), myeloperoxidase, matrix metalloproteinase-9, pregnancy associated plasma protein-A, soluble CD40 ligand.
Localization (soluble) of CD40 ligand in heart
6) Confidence 0.73 Published 2008 Journal Eur. Heart J. Section Body Doc Link 18682444 Disease Relevance 0.16 Pain Relevance 0
Hepatic enzymes were moderately increased and the IgM anti-EBV antibodies positive.
Localization (increased) of IgM associated with epstein-barr virus
7) Confidence 0.73 Published 2001 Journal Acta Haematol. Section Abstract Doc Link 11340255 Disease Relevance 1.17 Pain Relevance 0.19
In a large percentage of humans, experimental inoculation with a killed vaccine results in an early IgM response that wanes and is undetectable by 4 to 6 weeks, but this is not a model for natural infection (26).
Localization (response) of IgM associated with infection
8) Confidence 0.69 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2732454 Disease Relevance 1.38 Pain Relevance 0.04
The pathogenesis of B19-associated arthritis is believed to be driven by virus-specific antibody and immune complex formation since articular symptoms seem to coincide with the appearance of B19-specific IgM.
Localization (appearance) of IgM in articular associated with arthritis
9) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592818 Disease Relevance 1.29 Pain Relevance 0.26
In addition to existing in a membrane bound form, CD154 can also be released as a soluble molecule (sCD154), which has been shown to have biological functions [17].
Localization (released) of CD154
10) Confidence 0.60 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.50 Pain Relevance 0.54
It is conceivable that the activated CD4 T-cells in JIA synovium may be the source of sCD154, although it is possible that other cells, such as activated platelets release sCD154.
Localization (release) of sCD154 in platelets associated with arthritis
11) Confidence 0.60 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.55 Pain Relevance 0.60
In addition to existing in a membrane bound form, CD154 can also be released as a soluble molecule (sCD154), which has been shown to have biological functions [17].
Localization (released) of sCD154
12) Confidence 0.53 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.51 Pain Relevance 0.54
Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05).
Localization (decreases) of CD40L
13) Confidence 0.50 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.57 Pain Relevance 0.30
Of these persons, 25.5% (25/98) had evidence of recent RVFV infection (i.e., presence of IgM, viral RNA or virus, or >1 of these results), and 10% had evidence of past infection (i.e., presence of IgG alone).
Localization (presence) of IgM associated with infection
14) Confidence 0.46 Published 2007 Journal Emerging Infectious Diseases Section Body Doc Link PMC2878230 Disease Relevance 0.77 Pain Relevance 0
It is also possible that platelet activation does not always lead to release of CD40L into the plasma.
Localization (release) of CD40L in plasma
15) Confidence 0.45 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.27 Pain Relevance 0.11
In our study, it is possible that UFP exposure caused both an increase in platelet expression of CD40L and a more rapid clearance of CD40L from the plasma.
Localization (clearance) of CD40L in plasma
16) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.22 Pain Relevance 0
In patients with HF, the abundance of CD154 on platelets is increased and correlates with New York Heart Association classification [94].
Localization (abundance) of CD154 in platelets associated with myocardial infarction
17) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.13 Pain Relevance 0.37
These observations suggest that important relationships exist between local IL-6 and IgA2, IgM, and IgG3 responses in human small intestinal luminal secretions.
Localization (secretions) of IgM
18) Confidence 0.35 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.21 Pain Relevance 0.10
Twenty adult subjects with small intestinal bacterial overgrowth (N = 13), irritable bowel syndrome (N = 4), and nonulcer dyspepsia (N = 3) underwent endoscopic aspiration of secretions from the small intestinal mucosal surface for assessment of IL-6, IgA1, IgA2, IgM, IgG1, IgG2, IgG3, and IgG4 concentrations.
Localization (secretions) of IgM in bowel associated with spastic colon and nud
19) Confidence 0.33 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.15
Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course.
Localization (secreting) of IgM in lymph nodes associated with macroglobulinemia and malignant neoplastic disease
20) Confidence 0.26 Published 1980 Journal Am. J. Hematol. Section Abstract Doc Link 6776807 Disease Relevance 0.75 Pain Relevance 0

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