INT4577

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Context Info
Confidence 0.56
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 3.75
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thra) mitochondrion (Thra) nucleus (Thra)
DNA binding (Thra) nucleic acid binding transcription factor activity (Thra) transcription factor binding (Thra)
Anatomy Link Frequency
neuronal 2
blood 2
kidney 2
liver 1
RAO 1
Thra (Mus musculus)
Pain Link Frequency Relevance Heat
antiarrhythmic agent 18 99.64 Very High Very High Very High
isoflurane 8 99.60 Very High Very High Very High
Dopamine 22 99.54 Very High Very High Very High
guanethidine 4 99.42 Very High Very High Very High
antagonist 25 99.14 Very High Very High Very High
fibrosis 15 98.72 Very High Very High Very High
Clonidine 5 98.38 Very High Very High Very High
agonist 10 97.80 Very High Very High Very High
anesthesia 9 97.52 Very High Very High Very High
lidocaine 7 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 1 99.56 Very High Very High Very High
Diabetes Mellitus 8 99.36 Very High Very High Very High
Arrhythmia Under Development 1 99.12 Very High Very High Very High
Cirrhosis 36 98.96 Very High Very High Very High
Heart Rate Under Development 17 98.08 Very High Very High Very High
Hepatitis C Virus Infection 156 97.92 Very High Very High Very High
Pressure And Volume Under Development 7 95.52 Very High Very High Very High
Natriuresis 1 86.40 High High
Increased Venous Pressure Under Development 3 86.32 High High
Fibrosis 12 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacological suppression of RVR as an index for prevention against spontaneous VT remains controversial.
Negative_regulation (suppression) of RVR associated with heart rate under development
1) Confidence 0.56 Published 1983 Journal Jpn. Circ. J. Section Abstract Doc Link 6827769 Disease Relevance 0.93 Pain Relevance 0.09
In the third group of dogs, verapamil was infused continuously and suppressed RVR and AVE at a mean cumulative dose of 2.93 mg/kg.
Negative_regulation (suppressed) of RVR
2) Confidence 0.54 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.20
The alpha 1-adrenergic antagonists (prazosin and indoramin) have little or no clinical effect on GFR and ERPF/RBF; however, RVR is reduced.
Negative_regulation (reduced) of RVR associated with antagonist
3) Confidence 0.51 Published 1985 Journal J Clin Hypertens Section Abstract Doc Link 2872278 Disease Relevance 0.10 Pain Relevance 0.34
The central alpha 2-adrenergic agonists (alpha-methyldopa, clonidine, and guanabenz) have little or no clinical effect on GFR and ERPF/RBF; however, RVR is reduced.
Negative_regulation (reduced) of RVR associated with agonist and clonidine
4) Confidence 0.51 Published 1985 Journal J Clin Hypertens Section Abstract Doc Link 2872278 Disease Relevance 0.09 Pain Relevance 0.36
Finally, the peripheral adrenergic-neuronal blocking agents (guanadrel and guanethidine) decrease GFR and ERPF/RBF; RVR is also reduced.
Negative_regulation (reduced) of RVR in neuronal associated with guanethidine
5) Confidence 0.51 Published 1985 Journal J Clin Hypertens Section Abstract Doc Link 2872278 Disease Relevance 0.07 Pain Relevance 0.25
Calcium chloride reversed aprindine and verapamil-induced suppression of RVR and AVE.
Negative_regulation (suppression) of RVR
6) Confidence 0.40 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.20
During administration of 0.8% isoflurane, amrinone produced decreases in IVR and RVR, which were more pronounced than the vasodilator responses induced by this dose of isoflurane alone.
Negative_regulation (decreases) of RVR associated with isoflurane
7) Confidence 0.39 Published 1991 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2038924 Disease Relevance 0.09 Pain Relevance 0.43
The central and peripheral adrenergic-neuronal blocking agent reserpine has little or no clinical effect on GFR and ERPF/RBF; however, RVR is reduced.
Negative_regulation (reduced) of RVR in neuronal
8) Confidence 0.37 Published 1985 Journal J Clin Hypertens Section Abstract Doc Link 2872278 Disease Relevance 0.08 Pain Relevance 0.33
KCl, infused until AVE and RVR were suppressed, was successful when the mean serum potassium rose from 3.8 mEq/L to 7.2 mEq/L.
Negative_regulation (suppressed) of RVR
9) Confidence 0.35 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.20
Aprindine, 2.86 mg/kg, suppressed AVE and RVR in 14 of 14 dogs.
Negative_regulation (suppressed) of RVR
10) Confidence 0.35 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.20
Verapamil, by bolus, suppressed RVR in 41% and AVE in 21% of trials.
Negative_regulation (suppressed) of RVR
11) Confidence 0.35 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.21
A second group of dogs received various antiarrhythmic agents in an attempt to suppress the AVE and RVR.
Negative_regulation (suppress) of RVR associated with antiarrhythmic agent
12) Confidence 0.35 Published 1976 Journal Circulation Section Abstract Doc Link 1245038 Disease Relevance 0 Pain Relevance 0.18
A lack of RVR was also associated with liver fibrosis or cirrhosis.
Negative_regulation (lack) of RVR in liver associated with fibrosis and cirrhosis
13) Confidence 0.28 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 1.05 Pain Relevance 0.11
Individual study was also found to be predictive of RVR and cEVR even after adjusting for the effects of known factors such as Latino ethnicity which accounted for ?
Negative_regulation (predictive) of RVR
14) Confidence 0.28 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.21 Pain Relevance 0
In contrast, peginterferon alfa-2a dose reduction (yes vs no) was not a predictor of RVR or cEVR.


Negative_regulation (predictor) of RVR
15) Confidence 0.24 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.12 Pain Relevance 0
Both the PG analog and SKF 82526 significantly reduced renal vascular resistance (RVR) and were hypotensive, especially at the higher doses.
Negative_regulation (reduced) of RVR associated with hypotension
16) Confidence 0.22 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6148046 Disease Relevance 0.10 Pain Relevance 0.11
Furthermore, at a lower dose of TA-870 (2 mg/kg), renal vascular resistance (RVR) decreased and renal blood flow (RBF) increased.
Negative_regulation (decreased) of RVR in blood
17) Confidence 0.20 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1689425 Disease Relevance 0.08 Pain Relevance 0.19
Compensatory growth of the remnant kidney appeared not to be dependent on increments in renal blood flow; captopril decreased RVR and increased ERPF but had no effect on kidney weight, while indomethacin had no effect on ERPF and augmented remnant kidney weight.
Negative_regulation (decreased) of RVR in kidney
18) Confidence 0.16 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2648648 Disease Relevance 0.06 Pain Relevance 0.06
Peripheral alpha antagonists not only preserve renal hemodynamics, but decrease RVR and maintain renal perfusion autoregulation in the face of decreased systemic perfusion pressures.
Negative_regulation (decrease) of RVR in face associated with antagonist
19) Confidence 0.13 Published 1984 Journal Annu. Rev. Pharmacol. Toxicol. Section Abstract Doc Link 6145385 Disease Relevance 0 Pain Relevance 0.28
P-113 given intra-arterially to the contralateral kidney consistently increased renal blood flow and decreased RVR during RAO, but did not alter RVR significantly before RAO.
Negative_regulation (decreased) of RVR in RAO
20) Confidence 0.12 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1211457 Disease Relevance 0 Pain Relevance 0.08

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