INT45780

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Context Info
Confidence 0.07
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) signal transduction (GNRH1) extracellular space (GNRH1)
extracellular region (GNRH1) endoplasmic reticulum (PLOD1) cell-cell signaling (GNRH1)
Anatomy Link Frequency
ovaries 1
GNRH1 (Homo sapiens)
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 6 96.28 Very High Very High Very High
Enkephalin 4 87.80 High High
Opioid 2 75.00 Quite High
antagonist 45 55.44 Quite High
Dismenorea 1 24.36 Low Low
agonist 34 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 64 98.48 Very High Very High Very High
Endometriosis (extended) 15 91.48 High High
Embryo Loss 1 64.64 Quite High
Syndrome 7 62.64 Quite High
Obesity 22 55.92 Quite High
Hyperinsulinism 4 53.88 Quite High
Acanthosis 1 52.52 Quite High
Alopecia 7 51.28 Quite High
Acne 1 50.20 Quite High
Reprotox - General 3 41 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with FSH initially attenuated the response of LH to GnRH via the production of GnSAF from the ovaries, while around the midfollicular phase, the rising concentrations of E2 were able to overcome the attenuating effect of GnSAF and increase pituitary sensitivity to GnRH.
GnRH Positive_regulation (response) of LH in ovaries
1) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.06 Pain Relevance 0
However, the LHRH-induced rise in LH and FSH in young male volunteers was unaffected by pretreatment with a high-dose DAMME infusion.
LHRH-induced Positive_regulation (induced) of LH
2) Confidence 0.07 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.60
High GnRH expression increases LH and low GnRH increases FSH synthesis.
GnRH Positive_regulation (increases) of LH
3) Confidence 0.04 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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