INT4579

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Context Info
Confidence 0.43
First Reported 1975
Last Reported 2004
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 3.85
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
Plasma 3
blood 2
myocardium 1
area postrema 1
AGTR2 (Canis lupus)
Pain Term Frequency Confidence Heat
anesthesia 12 100.00 Very High Very High Very High
bradykinin 13 99.80 Very High Very High Very High
aspirin 15 99.20 Very High Very High Very High
halothane 5 99.06 Very High Very High Very High
Morphine 4 99.00 Very High Very High Very High
narcan 4 98.94 Very High Very High Very High
opiate 4 98.64 Very High Very High Very High
corticosteroid 1 96.28 Very High Very High Very High
antagonist 22 89.92 High High
medulla 1 87.60 High High
Disease Term Frequency Confidence Heat
Increased Venous Pressure Under Development 46 99.60 Very High Very High Very High
Myocardial Stunning 3 98.12 Very High Very High Very High
Hypoxia 220 97.56 Very High Very High Very High
Acid Base Imbalance 5 93.56 High High
Papillomavirus Infection 160 90.12 High High
Hemorrhage 2 85.88 High High
Volume Depletion And Dehydration 1 79.28 Quite High
Hemorrhagic Shock 1 75.00 Quite High
Thrombosis 5 72.08 Quite High
Cv Unclassified Under Development 1 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, naloxone-induced changes in vascular responsiveness were not responsible for the altered sensitivity of the area postrema to angiotensin II following blockade of endogenous opiates.
Neg (not) Regulation (responsible) of angiotensin II in area postrema associated with narcan and opiate
1) Confidence 0.43 Published 1981 Journal Hypertension Section Abstract Doc Link 7251091 Disease Relevance 0 Pain Relevance 0.77
Aspirin (35 mg/kg p.o. 2.5 h and 0.5 h prior to experiment) did not significantly change the renal effects of angiotensin II. 4.
Neg (not) Regulation (change) of angiotensin II associated with aspirin
2) Confidence 0.41 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3440322 Disease Relevance 0.10 Pain Relevance 0.18
Indomethacin did not alter the effects of angiotensin II on Na+ or K+ excretions. 3.
Neg (not) Regulation (effects) of angiotensin II
3) Confidence 0.41 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3440322 Disease Relevance 0.08 Pain Relevance 0.17
We investigated the effects of an intravenous (pentobarbital sodium) and inhalational (halothane) general anesthetic on the pulmonary vascular responses to angiotensin II and angiotensin-converting enzyme inhibition (CEI).
Regulation (responses) of angiotensin II associated with halothane
4) Confidence 0.40 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559942 Disease Relevance 0 Pain Relevance 0.17
Participation of angiotensin II and bradykinin in contractile function in dog stunned myocardium.
Regulation (Participation) of angiotensin II in myocardium associated with anesthesia, myocardial stunning and bradykinin
5) Confidence 0.30 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10556669 Disease Relevance 0.25 Pain Relevance 0.29
This suggests that at least one of these drugs has actions which affect angiotensin II-mediated vasoconstriction other than via cyclooxygenase inhibition.
Regulation (affect) of angiotensin II associated with increased venous pressure under development
6) Confidence 0.25 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3440322 Disease Relevance 0.19 Pain Relevance 0.17
In the context of previous experiments from our laboratory, studying the possible role of endothelial mediators (endothelins, nitric oxide and thromboxane A2) in the same anaesthetized dog model [19-21], we studied the effects of endogenous angiotensin II on pulmonary vascular tone in conditions of increased fractional inspired oxygen (FiO2; 0.4) and hypoxia.
Regulation (effects) of angiotensin II associated with hypoxia
7) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.68 Pain Relevance 0.04
In the first control group and the althesin-treated control group, changes in plasma ACTH and in plasma renin and angiotensin II concentrations were followed closely by changes in the levels of their respective dependent corticosteroids.
Regulation (changes) of angiotensin II in plasma associated with corticosteroid
8) Confidence 0.08 Published 1984 Journal Endocrinology Section Abstract Doc Link 6094155 Disease Relevance 0.22 Pain Relevance 0.30
Plasma renin activity and angiotensin II immunoreactivity were measured to determine whether activation or inhibition of the renin┬ľangiotensin system was present.


Regulation (immunoreactivity) of angiotensin II in Plasma
9) Confidence 0.05 Published 2004 Journal Crit Care Section Abstract Doc Link PMC522832 Disease Relevance 0.80 Pain Relevance 0
Absence of pulmonary vascular effect of the AT1 receptor blocker candesartan could be due to the action of angiotensin II on AT2 receptors.
Regulation (action) of angiotensin II
10) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.29 Pain Relevance 0
Plasma renin activity and angiotensin II immunoreactivity increased in the systemic and pulmonary circulations during hypoxia and after candesartan during FiO2 0.4 (Fig. 4).



Regulation (immunoreactivity) of angiotensin II in Plasma associated with hypoxia
11) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.90 Pain Relevance 0
Plasma renin activity and angiotensin II immunoreactivity were measured in arterial and mixed venous blood at baseline, and after ACE inhibition and after angiotensin II receptor blockade during increased inspired oxygen (FiO2 0.4) and hypoxia.
Regulation (immunoreactivity) of angiotensin II in blood associated with hypoxia
12) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.26 Pain Relevance 0
Independent osmoregulatory control of central and systemic angiotensin II concentrations in dogs.
Regulation (control) of angiotensin II
13) Confidence 0.01 Published 1986 Journal Am. J. Physiol. Section Title Doc Link 3706577 Disease Relevance 0.08 Pain Relevance 0.09
The effect of [Sar1, Ala8]angiotensin II (P-113) was compared before and during RAO on blood flow and vascular resistance of the contralateral kidney.
Regulation (effect) of angiotensin II in blood
14) Confidence 0.01 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1211457 Disease Relevance 0 Pain Relevance 0.10

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