INT45813

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Context Info
Confidence 0.46
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.66
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 4
brain 4
interneurons 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 204 100.00 Very High Very High Very High
Dopamine 127 99.84 Very High Very High Very High
halothane 3 99.72 Very High Very High Very High
Neurotransmitter 38 99.64 Very High Very High Very High
tetrodotoxin 13 99.52 Very High Very High Very High
Morphine 50 98.96 Very High Very High Very High
Nucleus accumbens 24 98.88 Very High Very High Very High
substance P 48 98.80 Very High Very High Very High
projection neuron 95 98.64 Very High Very High Very High
Action potential 32 98.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 95.88 Very High Very High Very High
Sensorineural Hearing Loss 66 84.08 Quite High
Sprains And Strains 83 80.40 Quite High
Epilepsy 6 75.00 Quite High
Conductive Hearing Loss 2 73.24 Quite High
Deafness 12 50.00 Quite Low
Neuropathic Pain 48 42.52 Quite Low
Absence Epilepsy 1 25.00 Low Low
Ganglion Cysts 26 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In brain slices, halothane was shown to inhibit the metabolic breakdown of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter.
Negative_regulation (inhibit) of Negative_regulation (breakdown) of GABA in brain associated with neurotransmitter, gaba and halothane
1) Confidence 0.46 Published 1981 Journal Anesthesiology Section Abstract Doc Link 6787954 Disease Relevance 0 Pain Relevance 0.56
In addition, several anesthetics have been shown to reduce desensitization of GABAA receptors [28,29] (Fig. 2A and B).
Negative_regulation (reduce) of Negative_regulation (desensitization) of GABAA
2) Confidence 0.42 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.50
Nonetheless, blockade of GABAA receptors during subthreshold responses decreases the synaptic potential in D1-SP+ MSNs since a depolarizing component: inhibition, was blocked (colored trace in Figure 3A).
Negative_regulation (decreases) of Negative_regulation (blockade) of GABAA associated with projection neuron and substance p
3) Confidence 0.41 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.51
When muscimol and CACA were applied together, they mimicked the inhibition of 1 mM GABA on retinal PER2::LUC rhythms (Figure 8A).
Negative_regulation (mimicked) of Negative_regulation (inhibition) of GABA associated with gaba
4) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.63
gamma-Aminobutyric acid (GABA) is considered to be the major inhibitory neurotransmitter in the brain and loss of GABA inhibition has been clearly implicated in epileptogenesis.
Negative_regulation (loss) of Negative_regulation (inhibition) of GABA in brain associated with neurotransmitter and gaba
5) Confidence 0.33 Published 2001 Journal CNS Drugs Section Abstract Doc Link 11475940 Disease Relevance 0.07 Pain Relevance 0.47
For example, blocking action potentials by chronically exposing cultured neurons with tetrodotoxin leads to a significant decline in mIPSC amplitudes due to a decrease in the average number of open GABA-gated channels and their inappropriate clustering at the postsynaptic membrane that includes ?
Negative_regulation (decline) of Negative_regulation (decrease) of GABA in neurons associated with tetrodotoxin, action potential and gaba
6) Confidence 0.13 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2517109 Disease Relevance 0.36 Pain Relevance 0.29
In contrast to resting activity, which in many individual neurons and in the total PTN population did not change after blockade of GABAA inhibition, activity during postural corrections was affected by GABAA receptor antagonism in 93% (all but two) of the PTNs.
Negative_regulation (blockade) of Negative_regulation (inhibition) of GABAA in neurons
7) Confidence 0.05 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.09
In the case of morphine, binding of morphine to GABA interneurons reduces GABA release, thereby reducing the GABA-mediated inhibition of dopamine release in the NAC, with a net result of increasing dopamine levels.
Negative_regulation (reducing) of Negative_regulation (inhibition) of GABA-mediated in interneurons associated with nucleus accumbens, dopamine, gaba and morphine
8) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.18 Pain Relevance 0.98
Gabapentin, a specific inhibitor of the cytosolic isoenzyme, showed greater potential to decrease the in vitro transamination rates of oxo-3-methylbutyrate and oxo-3-methylpentanoate than those of oxo-4-methylpentanoate and oxohexanoate; this correlated with its capacity to decrease insulin secretion. 4-Methylvaleric acid very strongly inhibited the transamination of all the branched-chain 2-oxoacids and blocked their capacity to decrease islet GABA and to stimulate insulin secretion.
Negative_regulation (blocked) of Negative_regulation (decrease) of GABA associated with gaba and gabapentin
9) Confidence 0.04 Published 2009 Journal Biochem. J. Section Abstract Doc Link 19173679 Disease Relevance 0 Pain Relevance 0.35
The benefit of deliberately switching the disinhibitory mechanism (i.e. from reduction of Eanion to blockade of glycine/GABAA receptors) is that blocking glycine/GABAA receptor-mediated input would uniformly adjust the fout/fout0 ratio to 1, thereby trivializing the variability of Eanion and ?
Negative_regulation (reduction) of Negative_regulation (blockade) of GABAA
10) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1624821 Disease Relevance 0.05 Pain Relevance 0.14

General Comments

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