INT45816

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Context Info
Confidence 0.28
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) transport (Gabrg1) extracellular space (Car2)
lyase activity (Car2) plasma membrane (Gabrg1) cytoplasm (Car2)
Anatomy Link Frequency
neurons 1
Car2 (Mus musculus)
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 8 100.00 Very High Very High Very High
antagonist 1 99.52 Very High Very High Very High
Morphine 7 97.04 Very High Very High Very High
analgesia 3 95.98 Very High Very High Very High
Action potential 2 94.16 High High
tetrodotoxin 1 92.92 High High
agonist 2 84.96 Quite High
tail-flick 1 74.00 Quite High
Glutamate 1 68.40 Quite High
GABAergic 1 66.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that antagonism of morphine analgesia by taurine may be caused by blockade of the morphine-induced inhibition of both ATP-dependent synaptosomal 45Ca2+ uptake and changes in synaptic vesicular 45Ca2+ localization, while the antagonism by GABA was not associated with synaptosomal Ca2+.
Ca2 Binding (associated) of GABA associated with gaba, analgesia and morphine
1) Confidence 0.28 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6788572 Disease Relevance 0 Pain Relevance 1.12
Exogenous GABA was found to initiate [Ca2+]i transients in GnRH neurons.
Ca2 Binding (initiate) of GABA in neurons associated with gaba
2) Confidence 0.04 Published 2008 Journal Endocrinology Section Abstract Doc Link 18703628 Disease Relevance 0.15 Pain Relevance 0.51

General Comments

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