INT45818

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 26.40
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4A) extracellular region (C4A)
Anatomy Link Frequency
plasma 1
blood 1
juvenile 1
skin 1
neutrophil 1
C4A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 50 100.00 Very High Very High Very High
spinal inflammation 11 100.00 Very High Very High Very High
cINOD 5 98.80 Very High Very High Very High
imagery 5 95.76 Very High Very High Very High
Inflammation 54 95.36 Very High Very High Very High
abdominal pain 4 94.80 High High
fibrosis 4 93.24 High High
Quantitative sensory testing 1 92.40 High High
Infliximab 37 91.76 High High
Pain 40 91.20 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 50 100.00 Very High Very High Very High
Low Back Pain 11 100.00 Very High Very High Very High
Disease 256 99.98 Very High Very High Very High
Systemic Lupus Erythematosus 246 99.40 Very High Very High Very High
Muscle Weakness 2 99.36 Very High Very High Very High
Purpura 49 99.12 Very High Very High Very High
Flavivirus Infection 320 98.16 Very High Very High Very High
Pressure And Volume Under Development 83 98.16 Very High Very High Very High
Metastasis 34 98.12 Very High Very High Very High
Systemic Sclerosis 6 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of serum total immunoglobulins and IgG subclasses and the frequencies of the immune response genes at the IGH@, HLA-A, -B, -DRB1, C4A, and C4B loci were analyzed in the patients and in control subjects.
Spec (analyzed) Gene_expression (analyzed) of C4A
1) Confidence 0.75 Published 2008 Journal J Pain Section Abstract Doc Link 18417422 Disease Relevance 1.61 Pain Relevance 0.58
MHC complement gene haplotypes or complotypes are designated by their BF, C2, C4A, and C4B alleles, in that arbitrary order [7].
Gene_expression (alleles) of C4A
2) Confidence 0.61 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
Therefore, we measured the levels of C4a, which correlates with the formation of the (C4b2b) C3 convertase, a hallmark for activation of the CP or LP (Figure 3).
Gene_expression (levels) of C4a
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.21 Pain Relevance 0
A new group of acetic acid (7a-c, R(1) = H), and propionic acid (7d-f, R(1) = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is attached via its C-3, C-4, and C-5 position was synthesized.
Gene_expression (synthesized) of C-4
4) Confidence 0.58 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20202839 Disease Relevance 0 Pain Relevance 0.07
Because the RPS-Form is based on the International Classification of Functioning, Disability, and Health (ICF) Model of Functioning and Disability, it could provide a common language for the description of human functioning and therefore facilitates multidisciplinary responsibility and coordination of interventions.
Gene_expression (based) of RPS-Form
5) Confidence 0.57 Published 2002 Journal Phys Ther Section Abstract Doc Link 12405874 Disease Relevance 0 Pain Relevance 0.07
Inverse correlations were observed between the levels of TN-C and C4S before HA injection and improvement of VAS after the five injections.
Gene_expression (levels) of C4S
6) Confidence 0.47 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
Novel amide conjugates of the NSAID naproxen (NAP, 1) with short-chain alpha-alkylamino acids (C4 to C6 alkyl chain) were synthesized through a carbodiimide (EDAC)-assisted coupling reaction and evaluated as dermal prodrugs of NAP.
Gene_expression (synthesized) of C4 associated with cinod
7) Confidence 0.45 Published 2005 Journal Current drug delivery Section Abstract Doc Link 16305419 Disease Relevance 0 Pain Relevance 0.10
Decreased serum levels of C4 and C1INH activity indicated a diagnosis of C1INH deficiency.
Gene_expression (levels) of C4
8) Confidence 0.45 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 17548946 Disease Relevance 0.36 Pain Relevance 0.30
Our findings suggest that HA injections are effective in patients whose knees contain low levels of TN-C and C4S, reflecting an early stage of OA and limited synovitis.


Gene_expression (levels) of C4S in knees
9) Confidence 0.42 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
RESULTS: After HA injections, levels of C6S, C4S, and KS decreased significantly.
Gene_expression (levels) of C4S
10) Confidence 0.42 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections.
Spec (determined) Gene_expression (Levels) of C4S
11) Confidence 0.42 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry for IgA, IgM IgG, C3, C4, kappa and lambda chains was completely negative.
Neg (negative) Gene_expression (negative) of C4
12) Confidence 0.39 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2936368 Disease Relevance 1.02 Pain Relevance 0.12
1-acid glycoprotein, type 2); and complement factors C3 and the C4A and C4B gene products.
Gene_expression (products) of C4A
13) Confidence 0.37 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.56 Pain Relevance 0.07
CH50, C3, C4, C3PA and circulating C3 conversion products were quantitated.
Gene_expression (products) of C4
14) Confidence 0.34 Published 1981 Journal Med Clin (Barc) Section Abstract Doc Link 6789016 Disease Relevance 0.77 Pain Relevance 0.54
The aspirated volume of synovialfluid (SFV) was recorded and levels of prostaglandin (PG) E2, transforming growth factor beta-1, tumor necrosis factor alpha, interleukin I receptor antagonist, chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate were measured.
Gene_expression (levels) of C4S
15) Confidence 0.17 Published 2001 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11491492 Disease Relevance 0 Pain Relevance 0
In addition, the levels of C4 and factor B were reduced in the more severe DHF patients (grades III and IV).
Gene_expression (levels) of C4 associated with flavivirus infection
16) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.40 Pain Relevance 0
In a pioneering study, Bokisch et al. [3] measured the levels of nine complement factors (C1q, C1s, C2, C3, C4, C5, C6, C8 and factor B) in serum samples of DHF patients (grades I to IV).
Gene_expression (levels) of C4 associated with flavivirus infection
17) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.43 Pain Relevance 0
The authors observed a correlation between levels of C3 with the levels of factor B and C4 and based on these correlations the authors demonstrated the direct involvement of both the classical and the alternative pathways in dengue severity.
Gene_expression (levels) of C4 associated with dengue
18) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.32 Pain Relevance 0
In proliferative lupus nephritis, elevation of anti-C1q level predicted renal flares with a sensitivity and specificity of 81% and 71%, respectively, which was only marginally better than other individual markers such as anti-dsDNA, C3, and C4 levels.
Gene_expression (levels) of C4 associated with renal disease
19) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.04 Pain Relevance 0
Transient low levels of C4 were detected in four cases (nine tested).
Gene_expression (detected) of C4
20) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174953 Disease Relevance 0.67 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox