INT45822

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Context Info
Confidence 0.01
First Reported 1981
Last Reported 1981
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.30
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Pah (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 99.64 Very High Very High Very High
narcan 9 76.00 Quite High
Opioid 3 32.88 Quite Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enkephalin analogue D-ala2, MePhe4, Met(0)-ol (DAMME), 8.3 X 10(-8) mol/l, augmented insulin release stimulated by glucose (5 or 7 mmol/l) by 76% and 47% respectively; increased insulin release stimulated by alpha-ketoisocaproate (7.5 mmol/l) by 23%; and enhanced insulin release in the presence of glibenclamide (10 microgram/ml) plus glucose (3.3 mmol/l) by 38%.
MePhe4 Positive_regulation (augmented) of Localization (release) of insulin associated with hyperinsulinism and enkephalin
1) Confidence 0.01 Published 1981 Journal Diabetologia Section Abstract Doc Link 6790327 Disease Relevance 0.10 Pain Relevance 0.24
The enkephalin analogue D-ala2, MePhe4, Met(0)-ol (DAMME), 8.3 X 10(-8) mol/l, augmented insulin release stimulated by glucose (5 or 7 mmol/l) by 76% and 47% respectively; increased insulin release stimulated by alpha-ketoisocaproate (7.5 mmol/l) by 23%; and enhanced insulin release in the presence of glibenclamide (10 microgram/ml) plus glucose (3.3 mmol/l) by 38%.
MePhe4 Positive_regulation (augmented) of Localization (release) of insulin associated with hyperinsulinism and enkephalin
2) Confidence 0.01 Published 1981 Journal Diabetologia Section Abstract Doc Link 6790327 Disease Relevance 0.10 Pain Relevance 0.25
The enkephalin analogue D-ala2, MePhe4, Met(0)-ol (DAMME), 8.3 X 10(-8) mol/l, augmented insulin release stimulated by glucose (5 or 7 mmol/l) by 76% and 47% respectively; increased insulin release stimulated by alpha-ketoisocaproate (7.5 mmol/l) by 23%; and enhanced insulin release in the presence of glibenclamide (10 microgram/ml) plus glucose (3.3 mmol/l) by 38%.
MePhe4 Positive_regulation (augmented) of Localization (release) of insulin associated with hyperinsulinism and enkephalin
3) Confidence 0.01 Published 1981 Journal Diabetologia Section Abstract Doc Link 6790327 Disease Relevance 0.10 Pain Relevance 0.24

General Comments

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