INT45824

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 1981
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.20
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
spinal cord 2
synaptic cleft 2
striatum 2
nucleus 2
respiratory 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 81 100.00 Very High Very High Very High
halothane 6 100.00 Very High Very High Very High
isoflurane 3 100.00 Very High Very High Very High
GABAergic 15 99.98 Very High Very High Very High
anesthesia 8 99.54 Very High Very High Very High
Hyperalgesia 1 99.52 Very High Very High Very High
Glutamate 3 99.40 Very High Very High Very High
tetrodotoxin 1 99.36 Very High Very High Very High
Spinal cord 4 99.00 Very High Very High Very High
ketamine 3 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.52 Very High Very High Very High
Convulsion 6 97.96 Very High Very High Very High
Respiratory Failure 3 91.68 High High
Sleep Disorders 1 87.12 High High
Epilepsy 4 83.00 Quite High
Respiratory Paralysis 3 82.08 Quite High
Unconsciousness 2 80.56 Quite High
INFLAMMATION 1 75.32 Quite High
Syndrome 1 62.84 Quite High
Brain Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, 25 mg/kg, i.v. thiopental, 140 mg/kg, i.v. ketamine, and 3% halothane produced anesthesia without significantly altering respiratory rate, increased GABA and decreased glutamate (except ketamine and phenobarbital) levels in rat brain stem and cortex, but not in caudate and cerebellum.
Neg (without) Regulation (altering) of Positive_regulation (increased) of GABA in respiratory associated with glutamate, gaba, anesthesia, ketamine and halothane
1) Confidence 0.24 Published 1994 Journal Life Sci. Section Abstract Doc Link 7911221 Disease Relevance 0.54 Pain Relevance 0.92
The effects of the anesthetic agents thiopental, halothane and isoflurane on the release of GABA induced by depolarization and/or reversal of the GABA carrier were investigated in a synaptosomal preparation obtained from the rat striatum.
Spec (investigated) Regulation (effects) of Positive_regulation (induced) of GABA in striatum associated with gaba, isoflurane and halothane
2) Confidence 0.24 Published 1995 Journal Brain Res. Section Abstract Doc Link 7743195 Disease Relevance 0 Pain Relevance 0.45
The increase of GABA in the nerve terminal caused by DPA is probably responsible for the initiation of the quasi-abstinence behavior, whereas the overflow of GABA into the synaptic cleft may be responsible for the suppression of this behavior via stimulation of presynaptic autoreceptors.
Spec (probably) Regulation (responsible) of Positive_regulation (increase) of GABA in synaptic cleft associated with gaba
3) Confidence 0.22 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6791219 Disease Relevance 0.06 Pain Relevance 0.64
The evidence for tonic GABAergic regulation of basal L-DOPA release via activation of inhibitory GABA(A) receptors in the nucleus tractus solitarii of anesthetized rats.
Regulation (regulation) of Positive_regulation (activation) of GABA in nucleus associated with anesthesia, gaba and gabaergic
4) Confidence 0.20 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.56
Endogenous GABA seems to regulate tonically basal DOPA release via activation of inhibitory GABA(A) receptors in the rat NTS.
Regulation (regulate) of Positive_regulation (activation) of GABA associated with gaba
5) Confidence 0.20 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081972 Disease Relevance 0 Pain Relevance 0.44
The increase of extracellular GABA after gamma-vinyl-GABA was not affected by infusion of tetrodotoxin.
Neg (not) Regulation (affected) of Positive_regulation (increase) of GABA associated with tetrodotoxin and gaba
6) Confidence 0.20 Published 1995 Journal Brain Res. Section Abstract Doc Link 7712166 Disease Relevance 0.43 Pain Relevance 0.75
Conversely, although chronic (7 days) administration of baclofen, a GABA(B) receptor agonist, abolishes baclofen-stimulated [(35)S]GTPgammaS binding in the spinal cord tissue, causes tolerance to the sedative and antinociceptive effects of the drug, increases the number of formalin-induced hind paw flinches, and induces mechanical hyperalgesia, this treatment had no effect on the levels of GABA(B1) or GABA(B2) mRNAs in the lumbar spinal cord.
Neg (no) Regulation (effect) of Neg (no) Positive_regulation (effect) of GABA in spinal cord associated with hyperalgesia, gaba, tolerance, agonist, antinociceptive and spinal cord
7) Confidence 0.20 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649368 Disease Relevance 0.17 Pain Relevance 1.05
It has been suggested that the depolarizing effect of GABA is the result of an active Na+–K+–Cl?
Regulation (depolarizing) of Positive_regulation (effect) of GABA associated with gaba
8) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox