INT45838

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 22
Disease Relevance 11.33
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPL) small molecule metabolic process (LPL) extracellular region (LPL)
plasma membrane (LPL) lipid metabolic process (LPL)
Anatomy Link Frequency
adipose tissue 7
plasma 4
muscle 4
skeletal muscle 1
LPL (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 6 97.76 Very High Very High Very High
diclofenac 6 96.26 Very High Very High Very High
agonist 262 94.40 High High
Catecholamine 9 76.48 Quite High
cINOD 14 75.00 Quite High
Bile 85 72.36 Quite High
Paracetamol 1 44.92 Quite Low
Angina 17 37.04 Quite Low
cytokine 10 29.68 Quite Low
nud 2 18.64 Low Low
Disease Link Frequency Relevance Heat
Obesity 375 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 235 99.60 Very High Very High Very High
Stress 14 99.28 Very High Very High Very High
Pancreatitis 10 98.44 Very High Very High Very High
Abdominal Pain 6 97.76 Very High Very High Very High
Injury 62 96.76 Very High Very High Very High
Hyperlipidemia 78 96.12 Very High Very High Very High
Congenital Anomalies 5 90.96 High High
Critical Illness 32 88.08 High High
Metabolic Syndrome 19 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first clinical trials in patients with LPL deficiency appear promising, with a significant decrease in the levels of plasma TGs observed in the first 3 months following the administration of alipogene tiparvovec, and an increase in local LPL activity and protein levels observed after 6 months.
Positive_regulation (increase) of LPL in plasma
1) Confidence 0.69 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.55 Pain Relevance 0.07
Exercise for 5–13 consecutive days increases LPL mRNA in skeletal muscle with no obvious changes in adipose tissue LPL mRNA [27].
Positive_regulation (increases) of LPL mRNA in adipose tissue associated with obesity
2) Confidence 0.62 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.52 Pain Relevance 0
Conversely, a two-week period of detraining in runners decreased LPL activity in skeletal muscle but increased LPL activity in adipose tissue [28].
Positive_regulation (increased) of LPL in skeletal muscle associated with obesity
3) Confidence 0.62 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.46 Pain Relevance 0
In 10 subjects who took indomethacin 150 mg/d p.o. for 3 days, plasma post-heparin lipoprotein lipase activity was also significantly increased.
Positive_regulation (increased) of lipoprotein lipase in plasma
4) Confidence 0.62 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6796423 Disease Relevance 0.07 Pain Relevance 0.21
We have studied the genetic basis of LPL deficiency in a 62-year-old black male with undetectable pre- and post-heparin plasma LPL mass and activity, DNA sequence analysis of the patient's LPL cDNA and gene as well as digestion with Bcl I and Asu I revealed that the proband is a homozygote for two separate gene defects.
Positive_regulation (deficiency) of LPL in plasma
5) Confidence 0.50 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.29 Pain Relevance 0.10
Since both indomethacin and diclofenac sodium are potent inhibitors of prostaglandin synthetase, these findings are consistent with the hypothesis tht prostaglandins are involved in the feed-back regulation of lipolysis, and mediate the inhibitory effect of lipolysis on lipoprotein lipase activity.
Positive_regulation (mediate) of lipoprotein lipase associated with diclofenac
6) Confidence 0.41 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6796423 Disease Relevance 0.07 Pain Relevance 0.21
Fibrates work by lowering hepatic apoC-III production and increasing lipoprotein lipase that will results in a decrease in VLDL production [10].
Positive_regulation (increasing) of lipoprotein lipase
7) Confidence 0.21 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 1.24 Pain Relevance 0
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Positive_regulation (Adipose) of LPL in Adipose tissue associated with obesity
8) Confidence 0.15 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.84 Pain Relevance 0
Fibrates work by lowering hepatic apoC-III production and increasing lipoprotein lipase that will results in a decrease in VLDL production [10].
Positive_regulation (results) of lipoprotein lipase
9) Confidence 0.14 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 1.23 Pain Relevance 0
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (attached) of LPL in adipose tissue associated with obesity and disorder of lipid metabolism
10) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (enzyme) of LPL in adipose tissue associated with obesity and disorder of lipid metabolism
11) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Positive_regulation (Adipose) of tissue lipoprotein lipase in Adipose tissue associated with obesity
12) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.84 Pain Relevance 0
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (enzyme) of lipoprotein lipase in adipose tissue associated with obesity and disorder of lipid metabolism
13) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (attached) of lipoprotein lipase in adipose tissue associated with obesity and disorder of lipid metabolism
14) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
results in increased lipolysis and plasma clearance of atherogenic triglyceride-rich lipoproteins via the activation of lipoprotein lipase and ApoAV and reduced production of the lipoprotein lipase inhibitor ApoCIII (Haubenwallner et al 1995; Staels et al 1995a; Stael et al 1998; Chapman et al 2006).
Positive_regulation (activation) of lipoprotein lipase in plasma
15) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.13 Pain Relevance 0
-dependent stimulation of the lipoprotein lipase gene, which facilitates the release of fatty acids from lipoprotein particles, and the down-regulation of apolipoprotein C-III [54].
Positive_regulation (stimulation) of lipoprotein lipase associated with disorder of lipid metabolism
16) Confidence 0.09 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.26 Pain Relevance 0.04
Increased triglyceride levels, an impaired lipoprotein-lipase activity, and reduced clearance of exogenous lipids have also been described in AKI patient populations [29].


Positive_regulation (Increased) of lipoprotein-lipase associated with injury
17) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2575562 Disease Relevance 1.12 Pain Relevance 0.04
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (attached) of LPL in muscle associated with obesity and disorder of lipid metabolism
18) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (enzyme) of LPL in muscle associated with obesity and disorder of lipid metabolism
19) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16
Clearance of TG-rich lipoproteins VLDL and chylomicrons is mediated by the enzyme lipoprotein lipase (LPL), which is attached to the capillary endothelium of muscle and adipose tissue.
Positive_regulation (attached) of lipoprotein lipase in muscle associated with obesity and disorder of lipid metabolism
20) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.37 Pain Relevance 0.16

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