INT45839

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Context Info
Confidence 0.55
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.64
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPL) small molecule metabolic process (LPL) extracellular region (LPL)
plasma membrane (LPL) lipid metabolic process (LPL)
Anatomy Link Frequency
plasma 3
macrophages 1
liver 1
adipose tissue 1
adipocytes 1
LPL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 100.00 Very High Very High Very High
diclofenac 3 97.56 Very High Very High Very High
agonist 50 91.40 High High
Endocannabinoid 72 75.00 Quite High
Cannabinoid 2 51.52 Quite High
Inflammation 60 27.28 Quite Low
Cannabinoid receptor 14 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 570 100.00 Very High Very High Very High
INFLAMMATION 67 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 32 100.00 Very High Very High Very High
Diabetes Mellitus 140 91.08 High High
Metabolic Syndrome 12 90.84 High High
Overweight 17 84.96 Quite High
Targeted Disruption 4 80.92 Quite High
Insulin Resistance 42 75.40 Quite High
Hyperandrogenism 16 71.52 Quite High
Atherosclerosis 16 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rise in dietary TG clearance after prior exercise is likely to be mediated in part by an up-regulation of lipoprotein lipase (LPL) activity.
Regulation (regulation) of LPL
1) Confidence 0.55 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.58 Pain Relevance 0
The rise in dietary TG clearance after prior exercise is likely to be mediated in part by an up-regulation of lipoprotein lipase (LPL) activity.
Regulation (regulation) of lipoprotein lipase
2) Confidence 0.55 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.58 Pain Relevance 0
Influence of two non-steroidal anti-inflammatory drugs on lipolysis and on plasma post-heparin lipoprotein lipase activity in normal man.
Regulation (Influence) of lipoprotein lipase in plasma associated with inflammation and cinod
3) Confidence 0.55 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 6796423 Disease Relevance 0.10 Pain Relevance 0.23
Exercise for 5–13 consecutive days increases LPL mRNA in skeletal muscle with no obvious changes in adipose tissue LPL mRNA [27].
Neg (no) Regulation (changes) of LPL mRNA in adipose tissue associated with obesity
4) Confidence 0.21 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584255 Disease Relevance 0.47 Pain Relevance 0
This SNP has been also associated to altered plasma levels of LPL, leptin, adiponectin, and resistin.
Regulation (altered) of LPL in plasma
5) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.32 Pain Relevance 0
has a similar function in macrophages and adipocytes as it modulates lipid homeostasis in both cell types via regulation of genes including LPL (lipoprotein lipase), ACAT (acetyl coenzyme A acetyltransferase) and PLA (phospholipase A) genes, and the levels of FFAs (free fatty acids), PGs (prostaglandins), and LTs (leukotriens).
Regulation (regulation) of LPL in macrophages associated with obesity
6) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.51 Pain Relevance 0
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Regulation (target) of LPL
7) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0
LPL activity is mostly regulated posttranslationally via altered secretion from liver of LPL-modulating factors, including apolipoprotein C-III (Apoc3), apolipoprotein A-V (Apoa5), Angiopoietin-like protein 3 (Angptl3), and Angiopoietin-like protein 4 (Angptl4).
Regulation (regulated) of LPL in liver associated with disorder of lipid metabolism
8) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.36 Pain Relevance 0.19
Therefore, since SAT LPL activity here correlated negatively with SAT AEA (and OEA or PEA) levels, while 2-AG levels showed an opposite tendency, it is possible to hypothesize, again, that increased AEA might not result in increased SAT CB1 activity, whereas decreased levels of 2-AG in the SAT might be partly responsible, via the corresponding reduction of CB1 activity, for the decreased LPL activity observed in this adipose depot.
Spec (might) Regulation (responsible) of LPL associated with obesity
9) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.52 Pain Relevance 0
Anandamide, OEA and PEA correlated positively (p < .05) with SAT leptin mRNA and free fatty acid during hyperinsulinaemic clamp, and negatively with SAT LPL activity and plasma HDL-cholesterol, which were all specifically altered in OBT2D subjects.


Regulation (altered) of LPL in plasma associated with obesity and disorder of lipid metabolism
10) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2868848 Disease Relevance 1.35 Pain Relevance 0.12
has a similar function in macrophages and adipocytes as it modulates lipid homeostasis in both cell types via regulation of genes including LPL (lipoprotein lipase), ACAT (acetyl coenzyme A acetyltransferase) and PLA (phospholipase A) genes, and the levels of FFAs (free fatty acids), PGs (prostaglandins), and LTs (leukotriens).
Regulation (regulation) of LPL in adipocytes associated with obesity
11) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.51 Pain Relevance 0

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