INT45840

Context Info Confidence 0.50 First Reported 1981 Last Reported 2010 Negated 2 Speculated 2 Reported most in Abstract Documents 35 Total Number 37 Disease Relevance 16.07 Pain Relevance 20.49

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)

Anatomy Link Frequency spinal cord 7 brain 6 urinary bladder 4 spinal 4 plasma 3 Ptgs1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 81 100.00 Pain 34 100.00 COX2 30 100.00 Calcitonin gene-related peptide 27 100.00 cOX1 24 100.00 cytokine 13 100.00 acular 13 100.00 antagonist 12 100.00 agonist 7 100.00 Clonidine 6 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 103 100.00 Bladder Cancer 6 100.00 Sepsis 6 99.84 Injury 1 99.64 Immunization 2 99.50 Stress 90 99.16 Osteoarthritis 8 98.92 Experimental Autoimmune Neuritis 7 98.60 Apoptosis 12 98.48 Adenocarcinoma 22 98.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IMPLICATIONS: Spinal injection of the alpha2-adrenergic agonist clonidine and the cyclooxygenase inhibitor ketorolac results in a synergistic interaction for antinociception in normal animals, suggesting that the combination of these drugs will enhance rather than detract from the analgesia of either alone.

Positive_regulation (results) of Gene_expression (injection) of cyclooxygenase in Spinal associated with antinociception, acular, agonist, analgesia and clonidine

1) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.88

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Positive_regulation (demonstrated) of Gene_expression (expression) of cyclooxygenase in brain

2) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Positive_regulation (demonstrated) of Gene_expression (expression) of cyclooxygenase in brain

3) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48

This is consistent with the apparent impossibility for the expression of cyclooxygenase active protein from cyclooxygenase-3 mRNA in the rat.

Positive_regulation (impossibility) of Gene_expression (expression) of cyclooxygenase

4) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.05 Pain Relevance 0.34

The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.

Spec (may) Positive_regulation (influence) of Gene_expression (expression) of cyclooxygenase

5) Confidence 0.49 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22

All NSAIDs, regardless of their cyclooxygenase selectivity, induced renal side effects including sodium retention and reduction in glomerular filtration rate.

Positive_regulation (induced) of Gene_expression (selectivity) of cyclooxygenase associated with cinod

6) Confidence 0.38 Published 2004 Journal Expert Opin Drug Saf Section Abstract Doc Link 15268645 Disease Relevance 1.42 Pain Relevance 0.71

To investigate the hypothesis that the gastric damage caused by NSAIDs is due not only to the decreased level of cyclooxygenase products but to the increased level of lipoxygenase products as well, different lipoxygenase inhibitors and leukotriene antagonists were tested.

Positive_regulation (increased) of Gene_expression (products) of cyclooxygenase associated with antagonist and cinod

7) Confidence 0.37 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.22 Pain Relevance 0.36

The formation of cyclooxygenase metabolites, particularly prostaglandin E2, prostaglandin F2 alpha, prostaglandin D2, 6-ketoprostaglandin F1 alpha, and thromboxane B2, and lipoxygenase metabolites such as 8(S)- and 12(S)-hydroxyeicosatetraenoic acids were significantly reduced in colonic mucosa and tumors of animals fed 320 ppm sulindac.

Positive_regulation (formation) of Gene_expression (metabolites) of cyclooxygenase associated with cancer

8) Confidence 0.33 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7882354 Disease Relevance 0.62 Pain Relevance 0.04

Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation.

Positive_regulation (Increased) of Gene_expression (expression) of cyclooxygenase in spinal cord associated with pain, spinal nerve ligature and spinal cord

9) Confidence 0.28 Published 2006 Journal Anesthesiology Section Title Doc Link 16436853 Disease Relevance 0.09 Pain Relevance 0.56

Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord.

Positive_regulation (increases) of in microglia Gene_expression (expression) of cyclooxygenase in spinal cord associated with cox1 and spinal cord

10) Confidence 0.26 Published 2007 Journal J Pain Section Title Doc Link 16949875 Disease Relevance 0.26 Pain Relevance 0.81

The expression of both cyclooxygenase (COX)-1 and COX-2, which are representative enzymes in prostaglandin synthesis, was evaluated in the sciatic nerve of rats with experimental autoimmune neuritis (EAN).

Positive_regulation (evaluated) of Gene_expression (expression) of cyclooxygenase in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis

11) Confidence 0.23 Published 2003 Journal Immunol. Invest. Section Abstract Doc Link 12916703 Disease Relevance 0.58 Pain Relevance 0.67

Addition of methemoglobin caused enhancement of prostaglandin endoperoxide synthetase mediated activation of paracetamol when initiated by both arachidonic acid and the hydroperoxides.

Positive_regulation (enhancement) of Gene_expression (synthetase) of prostaglandin endoperoxide synthetase associated with paracetamol

12) Confidence 0.22 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6797006 Disease Relevance 0 Pain Relevance 0.92

Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

Positive_regulation (Increased) of Gene_expression (expression) of cyclooxygenase in urinary bladder associated with bladder cancer and cox1

13) Confidence 0.22 Published 1999 Journal Carcinogenesis Section Title Doc Link 10590224 Disease Relevance 0.78 Pain Relevance 0.24

Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain.

Positive_regulation (Increased) of Gene_expression (production) of cyclooxygenase 1 in spinal associated with pain, osteoarthritis and cox1

14) Confidence 0.19 Published 2009 Journal Physiol Res Section Title Doc Link 18637715 Disease Relevance 0.77 Pain Relevance 1.15

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Positive_regulation (demonstrated) of in cerebellum Gene_expression (expression) of cyclooxygenase in brain

15) Confidence 0.17 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Positive_regulation (demonstrated) of in cerebellum Gene_expression (expression) of cyclooxygenase in brain

16) Confidence 0.17 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48

Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

Positive_regulation (induced) of Gene_expression (expression) of cyclooxygenase in urinary bladder associated with bladder cancer and cox1

17) Confidence 0.16 Published 1999 Journal Carcinogenesis Section Title Doc Link 10590224 Disease Relevance 0.80 Pain Relevance 0.25

Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?

Positive_regulation (sword) of Gene_expression (Role) of cyclooxygenase associated with anesthesia and sepsis

18) Confidence 0.15 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 14766677 Disease Relevance 0.22 Pain Relevance 0.31

Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?

Positive_regulation (effects) of Gene_expression (Role) of cyclooxygenase associated with anesthesia and sepsis

19) Confidence 0.15 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 14766677 Disease Relevance 0.22 Pain Relevance 0.31

This effect of NGF was not mediated by products of the cyclooxygenase pathway, and was also observed in mast cell-depleted rats.

Neg (not) Positive_regulation (mediated) of Gene_expression (products) of cyclooxygenase in mast cell associated with nerve growth factor

20) Confidence 0.13 Published 1996 Journal Pain Section Abstract Doc Link 8740610 Disease Relevance 0.74 Pain Relevance 1.29

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