INT4585

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Context Info
Confidence 0.46
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 12.40
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1)
Anatomy Link Frequency
brain 1
Platelets 1
Serping1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 73 99.12 Very High Very High Very High
agonist 13 98.72 Very High Very High Very High
abdominal pain 17 98.40 Very High Very High Very High
Opioid 1 98.08 Very High Very High Very High
Serotonin 6 96.68 Very High Very High Very High
substance P 2 95.48 Very High Very High Very High
Angina 1 92.68 High High
qutenza 7 90.24 High High
ischemia 28 87.28 High High
tetrodotoxin 4 85.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 100.00 Very High Very High Very High
Apoptosis 14 99.76 Very High Very High Very High
Disease 104 99.66 Very High Very High Very High
Hereditary Angioedema 221 99.28 Very High Very High Very High
INFLAMMATION 80 99.12 Very High Very High Very High
Pruritus 6 98.82 Very High Very High Very High
Abdominal Pain 17 98.40 Very High Very High Very High
Coronary Artery Disease 42 98.20 Very High Very High Very High
Pressure And Volume Under Development 149 97.64 Very High Very High Very High
Vomiting 19 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant C1-INH, produced in transgenic animals, has recently been produced for treatment of HAE, and clinical trials are in progress.
Gene_expression (produced) of C1-INH associated with targeted disruption and hereditary angioedema
1) Confidence 0.46 Published 2005 Journal Springer Semin. Immunopathol. Section Abstract Doc Link 16267649 Disease Relevance 1.55 Pain Relevance 0.15
Recombinant C1-INH, produced in transgenic animals, has recently been produced for treatment of HAE, and clinical trials are in progress.
Gene_expression (produced) of C1-INH associated with targeted disruption and hereditary angioedema
2) Confidence 0.46 Published 2005 Journal Springer Semin. Immunopathol. Section Abstract Doc Link 16267649 Disease Relevance 1.55 Pain Relevance 0.15
Among 21 members of the family who had never had symptoms of the disease, 7 also had low levels of C1-inhibitor.
Gene_expression (levels) of C1-inhibitor associated with disease
3) Confidence 0.41 Published 1975 Journal Schweiz Med Wochenschr Section Abstract Doc Link 1215911 Disease Relevance 0.70 Pain Relevance 0.09
In 32 patients complement studies were performed which in 28 cases revealed decreased levels of C1-inhibitor and almost normal values for C3 concentration.
Gene_expression (levels) of C1-inhibitor
4) Confidence 0.41 Published 1975 Journal Schweiz Med Wochenschr Section Abstract Doc Link 1215911 Disease Relevance 0.71 Pain Relevance 0.09
Measurement of inhibited FXIIa (as the FXIIa-C1-inhibitor complex) suggested that the level of this inhibitor complex was associated with cardiovascular risk [27].
Gene_expression (complex) of FXIIa-C1-inhibitor
5) Confidence 0.35 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.95 Pain Relevance 0.09
Sham-operated control mice (n = 6 per gene and time-point) showed a non-significant increase in the expression of Bcl-2, C1-Inh, and Fas at each time point assessed („sham“ group, n = 6 per gene and time-point, Fig. 7).
Gene_expression (expression) of C1-Inh associated with apoptosis
6) Confidence 0.35 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 0.89 Pain Relevance 0
Antigenic and functional C1 inhibitor levels correspond to 70% and 61.8% of adult values, respectively [11] and increase to the normal level by the age of 6 months to one year.
Gene_expression (levels) of C1 inhibitor
7) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.47 Pain Relevance 0
Type I HAE-C1-INH is characterized by reduced C4, as well as reduced antigenic and functional C1-INH levels.
Gene_expression (levels) of C1-INH associated with hereditary angioedema
8) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.51 Pain Relevance 0
No mutation of the C1-INH gene can be detected in 8 to 10 per cent of cases [8,9].
Gene_expression (detected) of C1-INH
9) Confidence 0.28 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.84 Pain Relevance 0
In any gastrointestinal preparations from PAR-2-knockout mice, SLIGRL-NH2 produced no responses.
Neg (no) Gene_expression (produced) of SLIGRL-NH2 associated with targeted disruption
10) Confidence 0.21 Published 2006 Journal Life Sci. Section Abstract Doc Link 16188279 Disease Relevance 0.16 Pain Relevance 0.16
We determined that a single base change (C-->T) at nucleotide 1482 in the seventh exon was present in the C1-INH gene.
Gene_expression (present) of C1-INH
11) Confidence 0.20 Published 1996 Journal Br. J. Dermatol. Section Abstract Doc Link 8733381 Disease Relevance 0.50 Pain Relevance 0.09
The serum levels of C1 inhibitor (C1-INH) and C4 were below normal.
Gene_expression (levels) of C1 inhibitor
12) Confidence 0.18 Published 1996 Journal Br. J. Dermatol. Section Abstract Doc Link 8733381 Disease Relevance 0.53 Pain Relevance 0.10
The serum levels of C1 inhibitor (C1-INH) and C4 were below normal.
Gene_expression (levels) of C1-INH
13) Confidence 0.18 Published 1996 Journal Br. J. Dermatol. Section Abstract Doc Link 8733381 Disease Relevance 0.53 Pain Relevance 0.10
There was no difference between patients who received C1-INH and those who did not with respect to the length of hospital or intensive care unit (ICU) stays, post-operative complications, or in-hospital mortality, regardless of the initiation time of C1-INH infusion.
Gene_expression (received) of C1-INH
14) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.46 Pain Relevance 0.06
There was no difference between patients who received C1-INH and those who did not with respect to the length of hospital or intensive care unit (ICU) stays, post-operative complications, or in-hospital mortality, regardless of the initiation time of C1-INH infusion.
Gene_expression (received) of C1-INH
15) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.52 Pain Relevance 0.06
Laboratory examination showed reduced levels of CH50, C2, C4, and C1 inhibitor (C1-INH).
Gene_expression (levels) of C1-INH
16) Confidence 0.10 Published 2005 Journal Mod Rheumatol Section Abstract Doc Link 17029094 Disease Relevance 0.89 Pain Relevance 0.19
Platelets possess C receptors CR2, CR3, CR4, C1q, C1-inhibitor, and factors D, and H.
Gene_expression (possess) of C1-inhibitor in Platelets
17) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.41 Pain Relevance 0.08
In contrast gamma-interferon reduced synthesis of C3 and P by 44% and 22% respectively, and stimulated C1-inhibitor synthesis twelve-fold.
Gene_expression (synthesis) of C1-inhibitor
18) Confidence 0.02 Published 1987 Journal J Clin Lab Immunol Section Abstract Doc Link 2449531 Disease Relevance 0 Pain Relevance 0.25
PMA, an activator of PK-C, stimulated the synthesis of C2, C3, B, P and C1-inhibitor approximately two-fold.
Gene_expression (synthesis) of C1-inhibitor
19) Confidence 0.02 Published 1987 Journal J Clin Lab Immunol Section Abstract Doc Link 2449531 Disease Relevance 0 Pain Relevance 0.27
An itch-related response, scratching, was elicited by intradermal injections of mosquito allergen (10 microg/site) in sensitized mice and SLIGRL-NH2 (protease-activated receptor-2 agonist, 50 nmol/site), histamine (100 nmol/site), serotonin (100 nmol/site) and substance P (100 nmol/site) in naive ones.
Gene_expression (injections) of SLIGRL-NH2 associated with pruritus, agonist, serotonin and substance p
20) Confidence 0.02 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18379077 Disease Relevance 0.23 Pain Relevance 0.28

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