INT4587

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Context Info
Confidence 0.47
First Reported 1975
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 19.11
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1)
Anatomy Link Frequency
skin 3
blood 2
plasma 2
B-cell 2
Serping1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 99.96 Very High Very High Very High
Pain 16 99.84 Very High Very High Very High
abdominal pain 28 99.32 Very High Very High Very High
Neuropathic pain 2 99.20 Very High Very High Very High
Hyperalgesia 10 99.00 Very High Very High Very High
Inflammation 83 98.88 Very High Very High Very High
qutenza 24 97.84 Very High Very High Very High
Peripheral nerve injury 6 97.60 Very High Very High Very High
Antinociceptive 2 93.44 High High
Visceral pain 10 90.80 High High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 483 99.98 Very High Very High Very High
Hematological Disease 16 99.56 Very High Very High Very High
Disease 123 99.54 Very High Very High Very High
Hypersensitivity 21 99.50 Very High Very High Very High
Abdominal Pain 28 99.32 Very High Very High Very High
INFLAMMATION 94 99.24 Very High Very High Very High
Neuropathic Pain 2 99.20 Very High Very High Very High
Pressure And Volume Under Development 303 99.04 Very High Very High Very High
Hyperalgesia 10 99.00 Very High Very High Very High
Angioedema 4 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary defect of C1-inhibitor (C1-INH), the regulatory protein of the initial classical pathway of complement, is the cause of hereditary angioedema.
Negative_regulation (defect) of C1-INH associated with hereditary angioedema
1) Confidence 0.47 Published 1991 Journal Immunol. Invest. Section Abstract Doc Link 1864632 Disease Relevance 0.38 Pain Relevance 0.08
BACKGROUND: Skin swellings are the most frequent symptoms in hereditary angio-oedema (HAE) arising out of C1-inhibitor (C1-INH) deficiency.
Negative_regulation (deficiency) of C1-INH in Skin associated with pressure and volume under development
2) Confidence 0.45 Published 2008 Journal Allergy Section Abstract Doc Link 18445189 Disease Relevance 0.17 Pain Relevance 0.10
Hereditary angioneurotic oedema is an autosomal dominant disease associated with serum deficiency of functional C1-inhibitor.
Negative_regulation (deficiency) of C1-inhibitor associated with hereditary angioedema and disease
3) Confidence 0.42 Published 1994 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7992951 Disease Relevance 0.46 Pain Relevance 0.07
In 32 patients complement studies were performed which in 28 cases revealed decreased levels of C1-inhibitor and almost normal values for C3 concentration.
Negative_regulation (decreased) of C1-inhibitor
4) Confidence 0.40 Published 1975 Journal Schweiz Med Wochenschr Section Abstract Doc Link 1215911 Disease Relevance 0.71 Pain Relevance 0.09
Hereditary angioedema (HAE) is a noninflammatory disorder due to reduced C1-inhibitor level and/or function and characterized by recurrent, circumscribed, and self-limiting episodes of cutaneous and mucous membrane swellings involving different organs.
Negative_regulation (reduced) of C1-inhibitor associated with hereditary angioedema
5) Confidence 0.40 Published 2007 Journal Am. J. Med. Sci. Section Abstract Doc Link 17873543 Disease Relevance 0.54 Pain Relevance 0.06
C1 inhibitor (C1-INH) is a serine protease inhibitor (serpins) that inactivates several different proteases in the complement, contact, coagulation, and fibrinolytic systems.
Negative_regulation (inhibitor) of C1 inhibitor
6) Confidence 0.35 Published 2005 Journal Springer Semin. Immunopathol. Section Abstract Doc Link 16267649 Disease Relevance 0.23 Pain Relevance 0.03
C1 inhibitor (C1-INH) is a serine protease inhibitor (serpins) that inactivates several different proteases in the complement, contact, coagulation, and fibrinolytic systems.
Negative_regulation (inhibitor) of C1-INH
7) Confidence 0.35 Published 2005 Journal Springer Semin. Immunopathol. Section Abstract Doc Link 16267649 Disease Relevance 0.23 Pain Relevance 0.03
The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE).
Negative_regulation (deficiency) of C1-INH associated with hereditary angioedema
8) Confidence 0.35 Published 2005 Journal Springer Semin. Immunopathol. Section Abstract Doc Link 16267649 Disease Relevance 1.33 Pain Relevance 0.16
CONCLUSIONS: The C1-INH concentrate has proven to be highly effective and safe for treating skin swellings in patients with HAE arising out of C1-INH deficiency.


Negative_regulation (deficiency) of C1-INH in skin
9) Confidence 0.33 Published 2008 Journal Allergy Section Body Doc Link 18445189 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The C1-INH concentrate has proven to be highly effective and safe for treating skin swellings in patients with HAE arising out of C1-INH deficiency.


Negative_regulation (effective) of C1-INH in skin
10) Confidence 0.33 Published 2008 Journal Allergy Section Body Doc Link 18445189 Disease Relevance 0 Pain Relevance 0
The defect of C1-INH is responsible for the activation of the start phases of the complement system and of the kinin system.
Negative_regulation (defect) of C1-INH
11) Confidence 0.21 Published 1987 Journal Z Gastroenterol Section Abstract Doc Link 3617844 Disease Relevance 0.68 Pain Relevance 0.08
The deficiency of the C1 inhibitor (C1-INH) is inherited as an autosomal dominant trait.
Negative_regulation (deficiency) of C1-INH
12) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.31 Pain Relevance 0.03
The deficiency of the C1 inhibitor (C1-INH) is inherited as an autosomal dominant trait.
Negative_regulation (deficiency) of C1 inhibitor
13) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.30 Pain Relevance 0.03
Type I HAE-C1-INH is characterized by reduced C4, as well as reduced antigenic and functional C1-INH levels.
Negative_regulation (reduced) of C1-INH associated with hereditary angioedema
14) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.51 Pain Relevance 0
In Type II HAE-C1-INH C4 is reduced and antigenic C1-INH level is high or normal and the functional activity of C1-INH is reduced [4,5].
Negative_regulation (reduced) of C1-INH associated with hereditary angioedema
15) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.51 Pain Relevance 0
SLIGRL-NH2, but not LRGILS-NH2, 6-18 h after administration, and unaffected by i.p.
Neg (unaffected) Negative_regulation (unaffected) of SLIGRL-NH2
16) Confidence 0.19 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15037813 Disease Relevance 0.65 Pain Relevance 1.54
SLIGRL-NH2, but not LRGILS-NH2, 6-18 h after administration, and unaffected by i.p.
Neg (unaffected) Negative_regulation (unaffected) of LRGILS-NH2
17) Confidence 0.19 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15037813 Disease Relevance 0.64 Pain Relevance 1.54
In Type II HAE-C1-INH C4 is reduced and antigenic C1-INH level is high or normal and the functional activity of C1-INH is reduced [4,5].
Negative_regulation (reduced) of C1-INH associated with hereditary angioedema
18) Confidence 0.17 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.51 Pain Relevance 0
Because LPS-gene profiling indicated repression of the complement classical pathway [C1qa, C1qb and C1qc downregulation and Serping1 (C1-Inhibitor) upregulation], we further characterized the temporal dynamic of this process (Figure S2).
Negative_regulation (downregulation) of C1-Inhibitor associated with repression
19) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.10 Pain Relevance 0
The syndrome of acquired angio-oedema is characterized by late onset of recurrent bouts of angio-oedema or abdominal pain and may be caused by an acquired deficiency of C1-inhibitor (C1-INH), the inhibitor of the first component of complement.
Negative_regulation (deficiency) of C1-INH associated with pressure and volume under development, abdominal pain and syndrome
20) Confidence 0.07 Published 1998 Journal Neth J Med Section Abstract Doc Link 9573738 Disease Relevance 0.69 Pain Relevance 0.10

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