INT45878

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.28
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1)
plasma membrane (NEU1) lysosome (NEU1)
Anatomy Link Frequency
internal 1
platelet 1
whole organism 1
NEU1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 2 97.98 Very High Very High Very High
Inflammation 235 87.92 High High
Pain 5 83.52 Quite High
cytokine 100 13.04 Low Low
Potency 16 6.00 Low Low
tolerance 19 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Dysuria 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 49 100.00 Very High Very High Very High
Cancer 120 99.88 Very High Very High Very High
Bacterial Vaginosis 96 99.40 Very High Very High Very High
Liver Failure 8 98.80 Very High Very High Very High
Malignant Neoplastic Disease 8 98.76 Very High Very High Very High
Acne 656 98.00 Very High Very High Very High
Sepsis 8 97.72 Very High Very High Very High
Breast Cancer 125 97.64 Very High Very High Very High
Reprotox - General 2 12 94.24 High High
Cellulitis 8 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some tumors TSP1 seems to promote tumor progression.(54–56) Other in vivo and clinical studies have shown an inverse correlation between TSP1 expression, malignancy and poorer prognosis.(57,58) When mice carrying the oncogene neu/erbB2 were crossed with TSP1 null mice, the number of mammary tumors and angiogenesis increased.
Gene_expression (crossed) of neu associated with malignant neoplastic disease and cancer
1) Confidence 0.65 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.01 Pain Relevance 0.03
Targeted therapy against human epidermal growth factor receptor 2 (anti-HER-2) is very effective in tumors that overexpress HER-2/neu receptors, but cost largely prevents its use in resource-limited environments.
Gene_expression (overexpress) of neu associated with cancer
2) Confidence 0.39 Published 2008 Journal Cancer Section Abstract Doc Link 18837019 Disease Relevance 0.45 Pain Relevance 0.08
After IPTG induction, over-expressed sialidase-6xNH fusion protein from E. coli was detected by SDS-PAGE with Coomassie blue staining at approximately 53.1 kDa molecular weight (Figure 1A).
Gene_expression (expressed) of sialidase
3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.17 Pain Relevance 0
The sialidase expression was confirmed by NanoLC-LTQ MS/MS mass spectrometric sequencing after in-gel trypsin digestion (Figure 1C).
Gene_expression (expression) of sialidase
4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.11 Pain Relevance 0
Real-time PCR revealed that the P. acnes expressed sialidase (Text S1 and Figure S1).
Gene_expression (expressed) of sialidase
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.23 Pain Relevance 0
An internal peptide (VVELSDGTLMLNSR; 316–329 amino acid residues) of sialidase is presented (Figure 1C), validating the expression of recombinant sialidase.


Gene_expression (expression) of sialidase in internal
6) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.16 Pain Relevance 0
The cell wall anchored sialidase presented in this article shares low identity with other surface sialidases in other pathogens [6].
Gene_expression (presented) of sialidase
7) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.87 Pain Relevance 0
The number of P. acnes in sialidase-immunized mice was not significantly different with that in GFP-immunized mice, indicating that sialidase immunization did not change the growth of P. acnes.
Gene_expression (immunization) of sialidase associated with immunization
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.76 Pain Relevance 0.07
Many proteins with molecular weights greater than 50 kDa were immunoreactive with mouse serum obtained from the heat killed P. acnes-immunized mice (Figure 3A, lane 3), however, sialidase was not (Figure 3A, lane 1), indicating that mice immunized with whole organism P. acnes do not produce antibodies to sialidase.
Neg (not) Gene_expression (produce) of sialidase in whole organism
9) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.45 Pain Relevance 0
Although creation of P. acnes with sialidase mutation or over-expression may directly address the role of sialidase in the virulence of P. acnes, it may be a challenge to genetically alter all sialidases in individual P. acnes.
Gene_expression (expression) of sialidase
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.51 Pain Relevance 0.03
Harigopal et al studied the prognostic significance of AIB1, TIF2 and NCoR protein expression in 670 breast cancer specimens by breast tissue microarray, and demonstrated the relationship of coregulatory proteins to ER, PR and HER2/neu.61 High AIB1 expression was associated with poor patient outcome (P = 0.002), while no association was noted for TIF2 (P = 0.376) or NCoR (P = 0.12).
Gene_expression (expression) of neu associated with breast cancer
11) Confidence 0.22 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.24 Pain Relevance 0
The failure of platelet inhibitors to block the increase in N-acetyl-beta-glucosaminidase, and the efficacy of lidocaine to do so without altering LA-PF4 secretion, suggest that leukocytes, not platelets, are the primary source of this lysosomal enzyme.
Gene_expression (source) of lysosomal enzyme in platelet associated with lidocaine
12) Confidence 0.04 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0.08 Pain Relevance 0.18
detecting sialidase produced by pathogens associated with the condition [49, 50].
Gene_expression (detecting) of sialidase
13) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2662373 Disease Relevance 1.14 Pain Relevance 0.04
detecting sialidase produced by pathogens associated with the condition [49, 50].
Gene_expression (produced) of sialidase
14) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2662373 Disease Relevance 1.10 Pain Relevance 0.04

General Comments

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