INT45899

Context Info Confidence 0.27 First Reported 1982 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.85 Pain Relevance 0.64

plasma membrane (LGR6) signal transducer activity (LGR6)

LGR6 (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 5 100.00 opiate 7 99.24 antagonist 1 98.60 Pain 3 67.36

Disease Link Frequency Relevance Heat Endometriosis (extended) 3 100.00 Insulin Resistance 3 90.24 Cryptorchidism 2 90.24 Acanthosis 2 89.44 Hypopituitarism 3 88.96 Diabetes Mellitus 2 86.60 Syndrome 5 85.04 Reprotox - General 3 1 78.16 Atherosclerosis 1 70.24 Reprotox - General 2 1 69.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, thus far, soy-based diets have generally failed to produce epithelial proliferation in ovariectomized rats and monkeys or menopausal women, and clinical studies have produced mixed evidence for effects of soy isoflavones on the human menstrual cycle or post-menopausal gonadotropin secretion.

Regulation (effects) of Localization (secretion) of gonadotropin associated with endometriosis (extended)

1) Confidence 0.27 Published 1998 Journal Baillieres Clin. Endocrinol. Metab. Section Abstract Doc Link 10384819 Disease Relevance 0.57 Pain Relevance 0.07

Responsiveness of gonadotropin secretion to infusion of an opiate-receptor antagonist in hypogonadotropic individuals.

Regulation (Responsiveness) of Localization (secretion) of gonadotropin associated with antagonist, narcan and opiate

2) Confidence 0.10 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6809778 Disease Relevance 0.31 Pain Relevance 0.51

Furthermore, the study confirms previous data concerning the key role of estrogens on male bone maturation, at least in part, and regulation of gonadotropin secretion.

Regulation (regulation) of Localization (secretion) of gonadotropin

3) Confidence 0.06 Published 2004 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14715828 Disease Relevance 0.97 Pain Relevance 0.06

General Comments

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