INT45914

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Context Info
Confidence 0.65
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 24.25
Pain Relevance 8.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
spleen 3
neurons 2
dorsal horn 2
blood 1
spinal 1
Apcs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 87 100.00 Very High Very High Very High
Inflammatory mediators 78 99.98 Very High Very High Very High
intrathecal 18 99.98 Very High Very High Very High
tolerance 27 99.82 Very High Very High Very High
Spinal cord 27 99.82 Very High Very High Very High
Hyperalgesia 58 99.52 Very High Very High Very High
qutenza 34 99.34 Very High Very High Very High
Inflammation 110 99.16 Very High Very High Very High
Rostral ventrolateral medulla 132 98.84 Very High Very High Very High
central sensitization 7 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 405 100.00 Very High Very High Very High
Nervous System Injury 267 100.00 Very High Very High Very High
Obstructive Jaundice 266 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
INFLAMMATION 203 99.78 Very High Very High Very High
Hyperalgesia 63 99.52 Very High Very High Very High
Hypertension 12 99.28 Very High Very High Very High
Apoptosis 308 99.20 Very High Very High Very High
Hypoxia 30 99.06 Very High Very High Very High
Macroglobulinemia 2 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Gene_expression (levels) of SAP in spinal cord associated with spinal cord
1) Confidence 0.65 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.70
To examine whether the NK1-expressing neurons in deeper laminae of SP-SAP animals may intrinsically control behavioral responses to nociceptive heat stimuli, the behavioral responses were determined following blockade of NK1Rs by its antagonist CP-96,345 (36 nmol).
Gene_expression (animals) of SAP in neurons associated with nociception, antagonist and substance p
2) Confidence 0.65 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.48 Pain Relevance 0.82
Ouabain was administered i.p. 30 min after induction of anesthesia with alpha-chloralose (60 mg/kg i.p.). alpha-Chloralose alone produced a significant SAP decrease in both SH and NT rats and bradycardia in SH but no significant HR change in NT rats.
Neg (no) Gene_expression (produced) of SAP associated with heart rate under development, anesthesia and hypertension
3) Confidence 0.60 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.03 Pain Relevance 0.10
Antiinflammatory EffectThe inflammatory mediators produced in SAP and OJ can cause intestinal mucosal damage.
Gene_expression (produced) of SAP associated with inflammatory mediators, inflammation, pancreatitis and obstructive jaundice
4) Confidence 0.53 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.43 Pain Relevance 0.42
In our previous reports, we have detected the serum contents of some inflammatory mediators in SAP and OJ rats (including endotoxin, PLA2, and TNF-?)
Gene_expression (rats) of SAP associated with inflammatory mediators, pancreatitis and obstructive jaundice
5) Confidence 0.53 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.51 Pain Relevance 0.23
After treatment with Salvia miltiorrhizae, the pathological changes of spleen and thymus were mitigated, suggesting that Salvia miltiorrhizae is able to improve the pathological damage present in the spleen and thymus of SAP rats and the spleen of OJ rats.
Gene_expression (rats) of SAP in spleen associated with pancreatitis and obstructive jaundice
6) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.31 Pain Relevance 0
Comparing the pathological changes of spleen and thymus, we found that varying degrees of pathological damage were present in the spleen and thymus of SAP rats and the spleen of OJ rats in model control group but pathological damage in the thymus of OJ rats was slight.
Gene_expression (rats) of SAP in thymus associated with pancreatitis and obstructive jaundice
7) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.25 Pain Relevance 0.09
Serum amyloid P-component (protein SAP) levels in patients with Waldenström's macroglobulinaemia have been determined to be markedly elevated (83 +/- 34 micrograms/ml) compared with healthy adult controls (35 +/- 11 micrograms/ml) and patients with multiple myeloma (39 +/- 17 micrograms/ml).
Gene_expression (levels) of Serum amyloid P-component associated with macroglobulinemia, alzheimer's dementia and multiple myeloma
8) Confidence 0.40 Published 1982 Journal J Clin Lab Immunol Section Abstract Doc Link 6813503 Disease Relevance 0.82 Pain Relevance 0.12
Our results showed that, at 12 hours after operation, the expression level of Bax protein in the spleen of SAP rats in model control group was significantly higher than that in sham-operated group, and the pathological damage in the former group was aggravated though there were no obvious changes in the apoptosis index.
Gene_expression (expression) of SAP in spleen associated with pancreatitis and apoptosis
9) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 0.84 Pain Relevance 0
On the other hand, despite an initial anoxia during the critical time-window, animals with restored SAP and HR (Figs. 1b and 2) showed sustained augmentation of power density of LF component of SAP signals, alongside a return to normal tissue oxygen level, persistent enhancement of local blood flow and maintained temperature in the RVLM.


Gene_expression (restored) of SAP in blood associated with rostral ventrolateral medulla and hypoxia
10) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.05 Pain Relevance 0.38
Sustained anoxia beyond this point was accompanied by a progressive decline in microvascular perfusion to the RVLM and reduction in LF power that paralleled temporally the cessation of SAP or HR, followed by a drop in RVLM tissue temperature.
Gene_expression (cessation) of SAP associated with rostral ventrolateral medulla and hypoxia
11) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.96 Pain Relevance 0.39
In AP/SAP, glucocorticoid
(represented by dexamethasone) mainly inhibits the generation and/or effect of
Gene_expression (/) of SAP associated with pancreatitis and dexamethasone
12) Confidence 0.34 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 2.65 Pain Relevance 0.35
be relevant to expression of Caspase-3 protein in SAP.
Gene_expression (expression) of SAP associated with pancreatitis
13) Confidence 0.34 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.42 Pain Relevance 0.16
Selective ablation of spinal neurons possessing substance P receptors (NK-1 receptors) using the selective cytotoxin conjugate substance P-saporin (SP-SAP) decreases hyperalgesia and central sensitization.
Gene_expression (using) of SP-SAP in spinal associated with hyperalgesia, central sensitization and substance p
14) Confidence 0.30 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15456795 Disease Relevance 0.17 Pain Relevance 0.32
We have found in practice [38] that ideal SAP rat models can be induced by
Gene_expression (models) of SAP associated with pancreatitis
15) Confidence 0.29 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.43 Pain Relevance 0.30
These observations are consistent with the hypothesis that KC act as FasL-expressing APCs, and may have the ability to induce and maintain immune tolerance.
Gene_expression (-) of APCs associated with tolerance
16) Confidence 0.26 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.25 Pain Relevance 0.14
Induction of Ag-specific T cell tolerance by FasL-transfected APCs suggests a novel strategy for modulating the T cell response [16].
Gene_expression (transfected) of APCs in T cell associated with tolerance
17) Confidence 0.20 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.23 Pain Relevance 0.18
These observations are consistent with the hypothesis that KC act as FasL-expressing APCs, and may have the ability to induce and maintain immune tolerance.
Gene_expression (expressing) of APCs associated with tolerance
18) Confidence 0.20 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.25 Pain Relevance 0.14
Comparing the pathological changes of spleen and thymus, we found that varying degrees of pathological damage were present in the spleen and thymus of SAP rats and the spleen of OJ rats in model control group but pathological damage in the thymus of OJ rats was slight.
Gene_expression (rats) of SAP in spleen associated with pancreatitis and obstructive jaundice
19) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.25 Pain Relevance 0.09
Animals received an intrathecal injection of SSP-SAP or saline and 4 weeks later underwent SNI or sham surgery (ie. animals were organised in 4 groups: saline sham, saline SNI, SSP-SAP sham and SSP-SAP SNI).
Gene_expression (sham) of SSP-SAP associated with nervous system injury and intrathecal
20) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.93 Pain Relevance 0.25

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