INT45952

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 2.11
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
muscle 3
right atrium 2
myocardium 1
sinus 1
head 1
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 319 99.52 Very High Very High Very High
Analgesic 2 99.36 Very High Very High Very High
Pain threshold 3 95.28 Very High Very High Very High
Acupuncture 6 94.92 High High
metalloproteinase 44 94.72 High High
action potential duration 22 91.40 High High
fibrosis 22 78.08 Quite High
Nav1.1 11 65.60 Quite High
narcan 1 25.00 Low Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 99 98.68 Very High Very High Very High
Targeted Disruption 11 95.72 Very High Very High Very High
Pain 3 95.28 Very High Very High Very High
Fibrosis 55 85.28 High High
Aging 121 85.12 High High
Hypertrophy 66 76.88 Quite High
Obesity 33 75.00 Quite High
Necrosis 11 73.12 Quite High
Cancer 11 72.76 Quite High
Body Weight 11 43.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some points, such as Ho-Ku (LI-4) and Tsu-San-Li (St-36), produced more prominent analgesic effects than others.
Gene_expression (produced) of San associated with analgesic
1) Confidence 0.65 Published 1982 Journal Am. J. Chin. Med. Section Abstract Doc Link 6820758 Disease Relevance 0.26 Pain Relevance 0.71
The superior vena cava was then separated from the right atrium in order to separate the SAN head from the SAN tail.
Gene_expression (head) of SAN in right atrium
2) Confidence 0.21 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0
The abundance of MMP2 mRNA was similar in all tissues and there was a significant age-dependent decrease in MMP2 mRNA in the SAN head and atrial muscle at least (Fig. 7A).
Gene_expression (head) of SAN in muscle
3) Confidence 0.21 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.44 Pain Relevance 0.17
Immunohistochemistry demonstrated that SAN tissue expressing HCN4, but lacking the expression of Nav1.5 (lack of Nav1.5 explains why pacemaker action potential is slow), was also more widespread and extended further towards the inferior vena cava in the old animals.
Gene_expression (expressing) of SAN in inferior vena cava associated with action potential
4) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Abstract Doc Link PMC2845824 Disease Relevance 0.37 Pain Relevance 0.10
In Figs. 8A and B, the filled symbols (and solid lines) show the relationship between the abundance of mRNA for types 1 and 3 collagens and the abundance of vimentin mRNA in young animals (each point corresponds to different animal or region – SAN head, SAN tail, or atrial muscle); there is a significant correlation as expected.
Gene_expression (head) of SAN in head
5) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0
The superior vena cava was then separated from the right atrium in order to separate the SAN head from the SAN tail.
Gene_expression (head) of SAN in right atrium
6) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0
The increase in SAN tissue lacking expression of Nav1.5 possibly could help explain the increase in the SAN conduction time observed in the elderly and SAN exit block in sick sinus syndrome [30] if the SAN action potential has to propagate a greater distance from the leading pacemaker site in the SAN through tissue lacking Nav1.5 to reach the surrounding atrial muscle [2].
Gene_expression (expression) of SAN in muscle associated with action potential and heart rate under development
7) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.30 Pain Relevance 0.05
The SAN has a slow action potential, because Nav1.5 is not expressed in the SAN [2].
Neg (not) Gene_expression (expressed) of SAN associated with action potential
8) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.09 Pain Relevance 0.17
Another possibility is that it is the result of a decline in the funny current, If, because blockade of If slows pacemaking and familial sick sinus syndrome has also been linked to mutations in HCN4 (main ion channel responsible for If) [2]; If and HCN4 are present in the SAN [2].
Gene_expression (present) of SAN in sinus associated with heart rate under development
9) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.18 Pain Relevance 0.07
In young animals, like vimentin mRNA, mRNAs for types 1 and 3 collagens were more abundant in the SAN than in the atrial muscle (Fig. 7A).
Gene_expression (abundant) of SAN in muscle
10) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.06 Pain Relevance 0
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Gene_expression (expression) of SAN in myocardium
11) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16
However, the increase in SAN tissue lacking expression of Nav1.5 cannot explain the age-dependent decrease in the intrinsic heart rate, because blockade of Nav1.5 by 2 ?
Gene_expression (expression) of SAN in heart
12) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.34 Pain Relevance 0.04

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