INT4596

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Context Info
Confidence 0.42
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 22.59
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (SCD) endoplasmic reticulum (SCD)
Anatomy Link Frequency
blood 1
pulmonary artery 1
SCD (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 79 99.90 Very High Very High Very High
cytokine 2 99.36 Very High Very High Very High
carpal tunnel syndrome 2 97.44 Very High Very High Very High
substance P 18 97.22 Very High Very High Very High
Potency 2 94.76 High High
Neuropeptide 2 89.88 High High
Inflammation 11 87.56 High High
Arthritis 1 66.72 Quite High
ischemia 29 64.08 Quite High
antagonist 2 47.28 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 291 100.00 Very High Very High Very High
Sickle Cell Anemia 209 100.00 Very High Very High Very High
Heart Disease 50 100.00 Very High Very High Very High
Hemoglobinopathy 3 100.00 Very High Very High Very High
Pain 67 99.90 Very High Very High Very High
Cardiomyopathy 88 99.80 Very High Very High Very High
Hypertrophic Cardiomyopathy 49 99.68 Very High Very High Very High
Asthma 9 99.60 Very High Very High Very High
Arrhythmia Under Development 58 99.14 Very High Very High Very High
Hematological Disease 31 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most striking and rewarding results were the ones that proved the effectiveness of the screening programs in increasing the awareness among the public about these common hemoglobinopathies, especially SCD.



Positive_regulation (increasing) of SCD associated with sickle cell anemia and hemoglobinopathy
1) Confidence 0.42 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2931779 Disease Relevance 0.68 Pain Relevance 0
In fact, food items do not trigger SCD attacks unless there is accompanying G6PD deficiency, in which case the attack can be triggered by consumption of fava beans.
Neg (not) Positive_regulation (trigger) of SCD associated with sickle cell anemia
2) Confidence 0.42 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2931779 Disease Relevance 1.01 Pain Relevance 0.08
On the other hand, the occurrence of SCD associated to training and competitions for athletes is increased by 2.8 times compared to the average relative risk of non-competitive practitioners [20], hence giving rise to the following question: Does sports activity causes sudden death in young people?
Positive_regulation (increased) of SCD associated with sudden death and myocardial infarction
3) Confidence 0.40 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2923123 Disease Relevance 1.07 Pain Relevance 0
This pathological condition is not the only coronary anomaly that causes SCD.
Positive_regulation (causes) of SCD associated with myocardial infarction
4) Confidence 0.40 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2923123 Disease Relevance 1.34 Pain Relevance 0
In 1993, a premarital counseling service was organized and then expanded to include all health centers.2 In the year 2004, the Bahrain Government passed a law requiring all couples planning to get married to undergo free premarital counseling.3 In 1998 the student screening project began,4 and the newborn screening program for blood diseases was launched in 2007.5 All these programs were accompanied by educational campaigns that aimed at increasing public awareness about SCD as well as other common hereditary blood disorders.
Positive_regulation (increasing) of SCD in blood associated with sickle cell anemia and hematological disease
5) Confidence 0.39 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2931779 Disease Relevance 1.03 Pain Relevance 0
It appears that CBN increases the effect of delta9-THC on some aspects of physiological and psychological processes, but that these effects are small and cannot account for the greater potency which has been reported when plant material is used.
Positive_regulation (increases) of delta9-THC associated with potency
6) Confidence 0.39 Published 1975 Journal Pharmacology Section Abstract Doc Link 1221432 Disease Relevance 0.48 Pain Relevance 0.11
It appears that CBN increases the effect of delta9-THC on some aspects of physiological and psychological processes, but that these effects are small and cannot account for the greater potency which has been reported when plant material is used.
Positive_regulation (increases) of delta9-THC associated with potency
7) Confidence 0.39 Published 1975 Journal Pharmacology Section Abstract Doc Link 1221432 Disease Relevance 0.48 Pain Relevance 0.11
Regional Medical Center at Memphis (Tennessee) established an SCD unit and developed an inpatient care delivery model that decreases the burden of caring for SCD patients on its busy emergency department, improves SCD patients' satisfaction and access to timely quality care, and reduces the needless pain and suffering of SCD patients.
Positive_regulation (suffering) of SCD associated with sickle cell anemia, pain and emergencies
8) Confidence 0.36 Published 2008 Journal J Healthc Manag Section Abstract Doc Link 18856136 Disease Relevance 1.76 Pain Relevance 0.38
It seems unanimous that hypertrophic cardiomyopathy is the leading cause of SCD related to exercises in athletes younger than 30 years old [51,52] which would be responsible for around half of deaths and often appearing as first and only manifestation of the disease.
Positive_regulation (cause) of SCD associated with hypertrophic cardiomyopathy, disease and myocardial infarction
9) Confidence 0.29 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2923123 Disease Relevance 1.13 Pain Relevance 0.03
A large number of congenital cardiac anomalies may be found and listed as a cause of SCD during exercise; however, the most prevalent according to literature references are anomalous origin of left coronary artery from pulmonary artery and hypertrophic cardiomyopathy [34].

1.1 Origin of the left coronary artery from pulmonary artery trunk

Positive_regulation (cause) of SCD in pulmonary artery associated with hypertrophic cardiomyopathy and myocardial infarction
10) Confidence 0.27 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2923123 Disease Relevance 1.46 Pain Relevance 0
Despite the similar level of well-being in SCD patients compared with both norms and patients with other chronic diseases, patients with SCD experience significant decrements in other important aspects of HRQOL.
Positive_regulation (being) of SCD associated with sickle cell anemia and chronic disease
11) Confidence 0.25 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1253526 Disease Relevance 1.08 Pain Relevance 0.13
While PVCs and NSVT are frequently seen in the general population and are sometimes considered clinically insignificant, they mark a population at increased risk for cardiac disease including SCD and cardiomyopathy.
Positive_regulation (increased) of SCD associated with cardiomyopathy, heart rate under development, heart disease and myocardial infarction
12) Confidence 0.16 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 1.95 Pain Relevance 0
While often considered benign, these types of ventricular ectopy can have negative consequences through an increased risk of SCD, underlying cardiomyopathy, or induction of cardiomyopathy.
Positive_regulation (increased) of SCD associated with cardiomyopathy, arrhythmia under development and myocardial infarction
13) Confidence 0.16 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2922873 Disease Relevance 2.50 Pain Relevance 0
It has been shown that TWA has high sensitivity and negative predictive value for predicting SCD after myocardial infarction and is also useful for predicting SCD in patients with nonischemic cardiomyopathy.
Positive_regulation (predicting) of SCD associated with cardiomyopathy and myocardial infarction
14) Confidence 0.14 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Abstract Doc Link PMC1513519 Disease Relevance 1.12 Pain Relevance 0
Asthma is associated with increases in sickle cell disease (SCD)-related morbidity and mortality.
Positive_regulation (increases) of SCD associated with sickle cell anemia and asthma
15) Confidence 0.05 Published 2009 Journal Pediatr. Pulmonol. Section Abstract Doc Link 19504562 Disease Relevance 0.80 Pain Relevance 0.30
The SCD of patients receiving hemodialysis was significantly increased, and there was a positive correlation between SCD and the duration of hemodialysis.
Positive_regulation (increased) of SCD
16) Confidence 0.03 Published 1995 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 7699951 Disease Relevance 0.37 Pain Relevance 0.06
In patients receiving long-term hemodialysis for 10 years or more, the SCD was increased significantly in the groups patients with the complications of carpal tunnel syndrome (CTS), cystic radiolucencies (CRL) or destructive spondyl arthropathy (DSA) compared with the value in complication-free patients.
Positive_regulation (increased) of SCD associated with carpal tunnel syndrome and arthropathy
17) Confidence 0.03 Published 1995 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 7699951 Disease Relevance 0.47 Pain Relevance 0.10
SCD is caused by one of numerous mutations in the UBIAD1 gene [95,96].
Positive_regulation (caused) of SCD
18) Confidence 0.03 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.34 Pain Relevance 0
SP is a known stimulator of tumor necrosis factor-alpha (TNF-alpha) release and a promoter of interleukin-8 (IL-8), which are reported to be increased in SCD.
Positive_regulation (increased) of SCD associated with sickle cell anemia, necrosis, cancer and substance p
19) Confidence 0.03 Published 1998 Journal Blood Section Abstract Doc Link 9787150 Disease Relevance 1.48 Pain Relevance 0.78
The percentage of sera with detectable levels of IL-8 (>5.0 pmol/L) was increased in SCD patients as compared with the control group.
Positive_regulation (increased) of SCD associated with sickle cell anemia
20) Confidence 0.03 Published 1998 Journal Blood Section Abstract Doc Link 9787150 Disease Relevance 2.04 Pain Relevance 1.18

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