INT45961

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 22
Total Number 29
Disease Relevance 7.21
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cspg4) cell proliferation (Cspg4) plasma membrane (Cspg4)
intracellular (Cspg4) signal transducer activity (Cspg4)
Anatomy Link Frequency
glial cells 3
astrocytes 2
dorsal 1
pericyte 1
microglia 1
Cspg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 399 100.00 Very High Very High Very High
Hippocampus 57 100.00 Very High Very High Very High
sodium channel 9 99.96 Very High Very High Very High
Glutamate 37 98.96 Very High Very High Very High
imagery 56 98.90 Very High Very High Very High
Central nervous system 244 98.64 Very High Very High Very High
Spinal cord 728 96.96 Very High Very High Very High
Dorsal column 240 96.64 Very High Very High Very High
ischemia 67 94.64 High High
Thalamus 37 93.72 High High
Disease Link Frequency Relevance Heat
Hydrocephalus 78 99.92 Very High Very High Very High
Injury 1109 99.68 Very High Very High Very High
Cicatrix 101 99.00 Very High Very High Very High
Spinal Cord Injury 536 97.32 Very High Very High Very High
Cv Unclassified Under Development 53 94.64 High High
Rheumatoid Arthritis 57 91.52 High High
Disseminated Intravascular Coagulation 14 88.32 High High
Epilepsy 28 83.60 Quite High
Acidosis 21 79.72 Quite High
Contusions 10 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently reported that most of NG2 glycoprotein expressing glial cells, or NG2 glia, in rat hippocampus persistently express sodium channel currents (I(Na)) during development, but little is known about its function.
Gene_expression (expressing) of NG2 in glial cells associated with sodium channel and hippocampus
1) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17981402 Disease Relevance 0 Pain Relevance 0.27
We have recently reported that most of NG2 glycoprotein expressing glial cells, or NG2 glia, in rat hippocampus persistently express sodium channel currents (I(Na)) during development, but little is known about its function.
Gene_expression (express) of NG2 in glial cells associated with sodium channel and hippocampus
2) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17981402 Disease Relevance 0 Pain Relevance 0.30
We have recently reported that most of NG2 glycoprotein expressing glial cells, or NG2 glia, in rat hippocampus persistently express sodium channel currents (I(Na)) during development, but little is known about its function.
Gene_expression (expressing) of NG2 in glial cells associated with sodium channel and hippocampus
3) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17981402 Disease Relevance 0 Pain Relevance 0.27
NG2, a large transmembrane CSPG that can be cleaved proteolytically to become a secretory molecule [47], was detected around cells in the damaged white matter of hydrocephalic brains.
Gene_expression (detected) of NG2 in white matter
4) Confidence 0.57 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2488327 Disease Relevance 0.60 Pain Relevance 0
NG2+ cell responses
Gene_expression (responses) of NG2
5) Confidence 0.54 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2909395 Disease Relevance 0 Pain Relevance 0.24
These synaptically unresponsive cells stained positively for NG2 (Fig. 6A).
Gene_expression (stained) of NG2
6) Confidence 0.54 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2909395 Disease Relevance 0 Pain Relevance 0.11
Interestingly, the proteoglycan NG2 has been found to be expressed by vascular pericytes surrounding the nascent vessels [33-35].
Gene_expression (expressed) of NG2 in vessels
7) Confidence 0.46 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0
NG2, another large proteoglycan 300 kDa in size [20], was readily apparent in animals 1 week to 3 weeks age, but undetectable in the older rats.
Gene_expression (undetectable) of NG2
8) Confidence 0.44 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2488327 Disease Relevance 0.44 Pain Relevance 0
Aims of studies reported here were to examine the effect of salicylamide on the incorporation of radiosulfate into glycosaminoglycans (GAGs) and the biosynthesis of chondroitin 4-sulfate (Ch-4-S) and chondroitin 6-sulfate (Ch-6-S) in fetal rat limbs was studied.
Gene_expression (biosynthesis) of chondroitin 4-sulfate in limbs
9) Confidence 0.36 Published 1981 Journal Drug Nutr Interact Section Abstract Doc Link 6821388 Disease Relevance 0.07 Pain Relevance 0.09
Additional data file 1 is a figure showing that transplanted GRP cells express neurocan and NG2, but suppress host expression of these molecules at 4 days post transplantation to dorsal column injuries.
Gene_expression (express) of NG2 in dorsal associated with injury and dorsal column
10) Confidence 0.34 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.18 Pain Relevance 0.05
These concepts are supported by the expression of neurocan and NG2 by transplanted GDAsCNTF and GRPs, a result that was not observed for transplanted GDAsBMP [14].
Gene_expression (expression) of NG2
11) Confidence 0.34 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.71 Pain Relevance 0.40
GDACNTF and GRP transplantation did, however, result in a suppression of neurocan and NG2 expression by host tissue at sites of injury at 4 days post-injury, an effect we previously observed following transplantation of GDAsBMP [14].
Gene_expression (expression) of NG2 associated with injury
12) Confidence 0.34 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.14 Pain Relevance 0.03
Compared with GDAsBMP, GDAsCNTF express elevated levels of the axon-growth-inhibitory chondroitin sulfate proteoglycans (CSPGs) NG2 (Figure 2a,b) and phosphacan (Figure 2c,d), both of which are also expressed at high levels in glial scar tissue [18].
Gene_expression (expressed) of NG2 associated with cicatrix
13) Confidence 0.30 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.39 Pain Relevance 0.20
Identification of hippocampal NG2-expressing glia
Gene_expression (expressing) of NG2
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.09 Pain Relevance 0
Our current study shows that transplanted GDAsCNTF and GRP cells promote the suppression of neurocan and NG2 in host tissues to an extent comparable to that previously observed for GDAsBMP at 4 days post-transplantation [14]; nevertheless, they completely fail to align host astrocytes or support the regeneration of ascending dorsal column axons across sites of injury.
Gene_expression (promote) of NG2 in astrocytes associated with injury and dorsal column
15) Confidence 0.26 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.85 Pain Relevance 0.28
Compared with GDAsBMP, GDAsCNTF express elevated levels of the axon-growth-inhibitory chondroitin sulfate proteoglycans (CSPGs) NG2 (Figure 2a,b) and phosphacan (Figure 2c,d), both of which are also expressed at high levels in glial scar tissue [18].
Gene_expression (express) of NG2 associated with cicatrix
16) Confidence 0.26 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.35 Pain Relevance 0.21
Expression levels of phosphacan (320–340 kDa band) and NG2 (270–300 kDa band), respectively, were normalized for each sample to ?
Gene_expression (Expression) of NG2 in band
17) Confidence 0.26 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0 Pain Relevance 0
Antibodies and dilutions used: NG2 (Chemicon, 1:1000), anti-phosphacan (Developmental Studies Hybridoma Bank, 1:1000), ?
Gene_expression (Antibodies) of NG2
18) Confidence 0.26 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0 Pain Relevance 0
Primary antibodies against NG2 (mouse, 1?
Gene_expression (antibodies) of NG2
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0
Hippocampal NG2 glia have ASIC1a immunoreactivity
Gene_expression (glia) of NG2
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.16

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