INT45971

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Context Info
Confidence 0.51
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.20
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GOT1) small molecule metabolic process (GOT1) biosynthetic process (GOT1)
carbohydrate metabolic process (GOT1) cellular nitrogen compound metabolic process (GOT1) lysosome (GOT1)
Anatomy Link Frequency
liver 2
erythrocyte 1
brain 1
body 1
GOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 23 99.98 Very High Very High Very High
Neurotransmitter 12 99.48 Very High Very High Very High
Paracetamol 3 99.04 Very High Very High Very High
Bile 7 98.32 Very High Very High Very High
fibrosis 3 97.60 Very High Very High Very High
carpal tunnel syndrome 2 97.14 Very High Very High Very High
headache 13 96.68 Very High Very High Very High
addiction 40 96.44 Very High Very High Very High
methotrexate 109 96.16 Very High Very High Very High
alcohol 102 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 10 99.92 Very High Very High Very High
Fever 2 99.74 Very High Very High Very High
Liver Failure 2 99.68 Very High Very High Very High
Hepatitis 12 99.34 Very High Very High Very High
Nasopharyngitis 5 98.82 Very High Very High Very High
Fibrosis 2 97.60 Very High Very High Very High
Schizophrenia 2 97.40 Very High Very High Very High
Carpal Tunnel Syndrome 2 97.14 Very High Very High Very High
Manic Depressive Disorder 3 96.80 Very High Very High Very High
Headache 13 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transaminase levels showed striking elevation, with a serum glutamic-oxaloacetic transaminase level of over 15,000 IU/liter, and decreased rapidly, consistent with a toxic insult.
Negative_regulation (decreased) of Transaminase
1) Confidence 0.51 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6824012 Disease Relevance 0.49 Pain Relevance 0.24
Elevation in serum myoglobin and glutamic pyruvic transaminase and decline in arterial ketone body ratio were also detected.
Negative_regulation (decline) of transaminase in body
2) Confidence 0.16 Published 1996 Journal Masui Section Abstract Doc Link 8725600 Disease Relevance 0.78 Pain Relevance 0.31
The drug is contraindicated in patients with hepatitis or liver failure, and a monthly check of hepatic transaminase levels is recommended, for the first three months and every three months thereafter.


Negative_regulation (check) of transaminase in liver associated with liver failure and hepatitis
3) Confidence 0.09 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687624 Disease Relevance 0.95 Pain Relevance 0.26
The commonest adverse events in the bosentan group in the EARLY trial were nasopharyngitis and elevated liver enzymes.36 Twelve patients on bosentan developed transaminase levels over 3 times ULN, 10 within 20 weeks.
Negative_regulation (developed) of transaminase in liver associated with nasopharyngitis
4) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 1.39 Pain Relevance 0.11
Important adverse events were a rise in alanine transaminase, aspartate transaminase, total cholesterol, and triglyceride levels.
Negative_regulation (rise) of aspartate transaminase associated with disorder of lipid metabolism
5) Confidence 0.05 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.23 Pain Relevance 0.34
Important adverse events were a rise in alanine transaminase, aspartate transaminase, total cholesterol, and triglyceride levels.
Negative_regulation (rise) of transaminase associated with disorder of lipid metabolism
6) Confidence 0.05 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.23 Pain Relevance 0.32
Blood samples from four patients at the time of surgery to relieve the compression of the carpal tunnel syndrome, which was diagnosed by clinical and electromyographic evaluation, were differentially assayed to determine the specific activities and the % deficiencies of the erythrocyte glutamic oxaloacetic transaminase (EGOT).
Negative_regulation (deficiencies) of erythrocyte glutamic oxaloacetic transaminase in erythrocyte associated with carpal tunnel syndrome
7) Confidence 0.04 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 7302380 Disease Relevance 0.17 Pain Relevance 0.17
By day 22, our patient's transaminase and bilirubin values were decreased and his clinical condition improved.
Negative_regulation (decreased) of transaminase
8) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2978230 Disease Relevance 0.42 Pain Relevance 0.12
High fever dropped and serum transaminase and C-reactive protein levels decreased within three days after PTGBD.
Negative_regulation (decreased) of serum transaminase associated with fever
9) Confidence 0.04 Published 1997 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 9358811 Disease Relevance 0.68 Pain Relevance 0.18
Valproate may affect neurotransmitter GABA function (as a GABA transaminase inhibitor) in the human brain, making it an alternative to lithium salts in treatment of bipolar disorder.
Negative_regulation (inhibitor) of transaminase in brain associated with gaba, neurotransmitter and manic depressive disorder
10) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.87 Pain Relevance 0.78

General Comments

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