INT45975

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 22
Disease Relevance 19.70
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
plasma 1
leukocyte 1
hips 1
urine 1
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 219 100.00 Very High Very High Very High
Paracetamol 71 99.00 Very High Very High Very High
corticosteroid 12 97.08 Very High Very High Very High
Inflammatory marker 16 96.84 Very High Very High Very High
abdominal pain 8 96.16 Very High Very High Very High
Pain 32 95.28 Very High Very High Very High
Inflammatory mediators 32 94.08 High High
cytokine 298 93.60 High High
Arthritis 38 93.08 High High
methotrexate 2 90.00 High High
Disease Link Frequency Relevance Heat
Fever 502 100.00 Very High Very High Very High
INFLAMMATION 311 100.00 Very High Very High Very High
Alzheimer's Dementia 76 100.00 Very High Very High Very High
Appetite Loss 1 100.00 Very High Very High Very High
Serositis 1 100.00 Very High Very High Very High
Disease 219 99.90 Very High Very High Very High
Periodontal Disease 20 99.74 Very High Very High Very High
Syndrome 212 99.60 Very High Very High Very High
Amyloidosis 94 99.44 Very High Very High Very High
Coronary Artery Disease 7 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the serum amyloid A (SAA) levels remained elevated.
Positive_regulation (elevated) of SAA associated with alzheimer's dementia
1) Confidence 0.67 Published 2010 Journal Rheumatol. Int. Section Abstract Doc Link 20020137 Disease Relevance 1.02 Pain Relevance 0.32
There was a definite increase of serum amyloid-A-protein (SAA).
Positive_regulation (increase) of amyloid-A-protein associated with alzheimer's dementia
2) Confidence 0.59 Published 1983 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 6825596 Disease Relevance 1.32 Pain Relevance 0.10
Indeed, patients with chronic periodontal diseases have higher levels of SAA protein in secondary amyloidosis than patients without periodontal disease [22].
Positive_regulation (levels) of SAA protein associated with amyloidosis and periodontal disease
3) Confidence 0.55 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 2.49 Pain Relevance 0.19
The level of SAA increases during acute and chronic infections [6,7].
Positive_regulation (increases) of SAA associated with infection
4) Confidence 0.55 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.87 Pain Relevance 0.32
In contrast, an oxidation of the plasma E(h)GSSG was apparent for SAA insufficiency only with APAP.
Positive_regulation (apparent) of SAA in plasma associated with paracetamol
5) Confidence 0.50 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20207721 Disease Relevance 0 Pain Relevance 1.08
The treatment was well tolerated and induced rapid control of fever, anorexia and serositis, together with downregulation of interleukin (IL)-6, soluble TNF receptors (sTNFR) and IL-1ra, and the acute-phase proteins C-reactive protein (CRP) and serum amyloid A (SAA).
Positive_regulation (induced) of SAA associated with appetite loss, alzheimer's dementia, serositis and fever
6) Confidence 0.49 Published 1997 Journal Br. J. Rheumatol. Section Abstract Doc Link 9189062 Disease Relevance 1.89 Pain Relevance 0.60
Two genes

(SAA1 and SAA2) encode A-SAA and are coordinately induced in response to inflammation.

Positive_regulation (induced) of SAA1 associated with inflammation
7) Confidence 0.44 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17807 Disease Relevance 0.62 Pain Relevance 0.09
Two genes (SAA1 and SAA2) encode A-SAA

and are coordinately induced in response to inflammation.

Positive_regulation (induced) of SAA1 associated with inflammation
8) Confidence 0.44 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17807 Disease Relevance 1.14 Pain Relevance 0.16
This attenuation of PG synthesis in vivo sheds light on another potential benefit associated with increased SAA intake and adequate levels of tissue GSH.
Positive_regulation (increased) of SAA
9) Confidence 0.40 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.17 Pain Relevance 0.09
Serum amyloid A (SAA) and C-reactive protein (CRP) reactants of the acute phase of inflammation, have been shown to be increased in patients with CHD.
Positive_regulation (increased) of SAA associated with coronary artery disease, inflammation and alzheimer's dementia
10) Confidence 0.38 Published 2000 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10652189 Disease Relevance 1.33 Pain Relevance 0.28
This response to a low intake of SAA is causes antioxidant defenses to become compromised.
Positive_regulation (response) of SAA
11) Confidence 0.29 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0 Pain Relevance 0.04
Neither their approaches, which relies on the production of isotope enriched CO2, nor the nitrogen balance studies take into account the unique role of the SAA (sulfur amino acids), to provide S for sulfation.
Neg (Neither) Positive_regulation (role) of SAA
12) Confidence 0.29 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0 Pain Relevance 0
Serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA) were substantially elevated in patients with fever (Table 2 and Additional File 2, Figure S1) which is typical for the syndrome.
Positive_regulation (elevated) of SAA associated with syndrome, alzheimer's dementia and fever
13) Confidence 0.27 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.04 Pain Relevance 0.04
Two notable exceptions were febrile patients P05 and P06 that did not have elevated WBC at the time of sampling even though the febrile episode was consistent with previous febrile attacks and CRP and SAA levels were elevated.
Positive_regulation (elevated) of SAA associated with fever
14) Confidence 0.27 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.61 Pain Relevance 0
Acute phase proteins CRP and SAA are elevated
Positive_regulation (elevated) of SAA
15) Confidence 0.27 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.94 Pain Relevance 0.04
Any excess of SAA is oxidized to inorganic sulfate and excrete in the urine as neither organic nor inorganic excesses of sulfur can be stored.
Positive_regulation (excess) of SAA in urine
16) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.12 Pain Relevance 0.06
METHODS: Sixteen hips in 15 patients underwent SAA at an average age of 14.4 years.
Positive_regulation (underwent) of SAA in hips
17) Confidence 0.26 Published 2008 Journal J. Formos. Med. Assoc. Section Body Doc Link 18796362 Disease Relevance 0 Pain Relevance 0
Worthy of note are the elevated levels of SAA in some afebrile PFAPA samples, suggesting that SAA is an extremely sensitive inflammatory marker.
Positive_regulation (elevated) of SAA associated with inflammatory marker
18) Confidence 0.24 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.96 Pain Relevance 0.05
This is supported further by the observation of elevated levels of SAA in some patients during the afebrile period and in accordance with another study in which SAA levels fluctuated in patients with FMF that were completely asymptomatic; the authors of that studied concluded that the fluctuations were due to subclinical inflammatory activity [33].
Positive_regulation (elevated) of SAA associated with inflammation
19) Confidence 0.24 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.16 Pain Relevance 0.35
As in other periodic fever syndromes, there is a marked increase in CRP, SAA, ESR and leukocyte concentration [6-8], which are indicative of a prominent, acute inflammatory reaction.
Positive_regulation (increase) of SAA in leukocyte associated with inflammation, syndrome and fever
20) Confidence 0.24 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.12 Pain Relevance 0.17

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