INT4598

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Context Info
Confidence 0.54
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 4.69
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
blood 3
plasma 2
urine 2
cardiovascular system 1
heart 1
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 2 100.00 Very High Very High Very High
depression 1 100.00 Very High Very High Very High
butorphanol 8 99.98 Very High Very High Very High
epidural 2 99.84 Very High Very High Very High
analgesia 2 99.48 Very High Very High Very High
anesthesia 7 99.24 Very High Very High Very High
Clonidine 37 99.08 Very High Very High Very High
antagonist 8 97.78 Very High Very High Very High
Opioid 3 96.96 Very High Very High Very High
Pain 2 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Depression 1 100.00 Very High Very High Very High
Sprains And Strains 1 99.98 Very High Very High Very High
Hypothermia 4 99.74 Very High Very High Very High
Bordatella Infection 3 99.56 Very High Very High Very High
Diuresis 23 99.42 Very High Very High Very High
Volume Depletion And Dehydration 2 98.96 Very High Very High Very High
Pressure And Volume Under Development 2 98.52 Very High Very High Very High
Pain 2 96.84 Very High Very High Very High
Diabetes Insipidus 4 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ether inhibited alcohol dehydrogenase (ADH) activities in vitro in an uncompetitive fashion; Ki, ether concentration which produced 50% inhibition of NADH formation, was 9.7 mM.
Negative_regulation (inhibited) of ADH associated with alcohol
1) Confidence 0.54 Published 1985 Journal Pharmacology Section Abstract Doc Link 3160048 Disease Relevance 0 Pain Relevance 0.36
The plasma ADH level was high (114 pg/ml) just after surgery and decreased to a normal level (4.3 pg/ml) in the morning of the 2nd postoperative day.
Negative_regulation (decreased) of ADH in plasma
2) Confidence 0.48 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.25 Pain Relevance 0.37
Elevation of the plasma ADH level was partially suppressed by epidural analgesia combined with GOF anesthesia.
Negative_regulation (suppressed) of ADH in plasma associated with anesthesia, epidural and analgesia
3) Confidence 0.48 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.26 Pain Relevance 0.39
Butorphanol prevented the expected rise in urine osmolality and ADH excretion due to 31 h of dehydration.
Negative_regulation (prevented) of ADH in urine associated with volume depletion and dehydration and butorphanol
4) Confidence 0.43 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.18 Pain Relevance 0.53
We investigated further the role of ADH in kappa-induced diuresis by utilizing the Brattleboro rat, a strain lacking endogenous ADH.
Negative_regulation (lacking) of ADH associated with diuresis and sprains and strains
5) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3014247 Disease Relevance 0.37 Pain Relevance 0.26
Thus, clonidine-induced diuresis does not appear to be due to alpha adrenergic inhibition of ADH release but rather to direct renal effects.
Negative_regulation (inhibition) of ADH associated with diuresis and clonidine
6) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.68 Pain Relevance 0.80
Clonidine-induced diuresis was not at least due to the inhibition of ADH release.
Negative_regulation (inhibition) of ADH associated with diuresis and clonidine
7) Confidence 0.41 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8900500 Disease Relevance 0.66 Pain Relevance 1.20
Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion.
Negative_regulation (decrease) of ADH in urine
8) Confidence 0.38 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.16 Pain Relevance 0.50
The increased release of ADH after peripheral administration of isoproterenol was presumably due to the reduction in blood pressure and decreased baroreceptor inhibition of ADH release.
Negative_regulation (inhibition) of ADH in blood
9) Confidence 0.38 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.15 Pain Relevance 0.15
Pretreatment with phenoxybenzamine (100 microgram/kg, iv) completely blocked the effects of norepinephrine on blood pressure and heart rate but only partially (about 50%) inhibited the norepinephrine effect on ADH release.
Negative_regulation (inhibited) of ADH in blood
10) Confidence 0.38 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.19 Pain Relevance 0.23
The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH).
Spec (whether) Negative_regulation (depression) of ADH associated with diuresis, hypothermia and depression
11) Confidence 0.34 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597114 Disease Relevance 0.37 Pain Relevance 0.09
Prazosin decreased blood pressure significantly with a significant rise in heart rate and ADH release.
Negative_regulation (decreased) of ADH in heart associated with pressure volume 2 under development
12) Confidence 0.25 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.36 Pain Relevance 0.09
Pretreatment with yohimbine completely blocked the effect of NE on ADH release, and brought about a slight rise in blood pressure and heart rate.
Negative_regulation (blocked) of ADH in blood associated with pressure and volume under development
13) Confidence 0.25 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.34 Pain Relevance 0.08
However, the rats treated with quercetin showed an obvious decrease in ADH, ?
Negative_regulation (decrease) of ADH
14) Confidence 0.22 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 0.31 Pain Relevance 0.03
Ang II antagonist given intracerebroventricularly neither affected ADH release and the cardiovascular system in 0.15 M NaCl nor inhibited ADH release in response to osmotic stimulation.
Negative_regulation (inhibited) of ADH in cardiovascular system associated with antagonist
15) Confidence 0.06 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.23 Pain Relevance 0.05
Prevention of alpha 2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT.
Negative_regulation (Prevention) of ADH associated with bordatella infection
16) Confidence 0.04 Published 1987 Journal Am. J. Physiol. Section Title Doc Link 2886051 Disease Relevance 0.19 Pain Relevance 0.21

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