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Context Info
Confidence 0.13
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.83
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HRASLS)
Anatomy Link Frequency
endothelial cell 1
HRASLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 98.68 Very High Very High Very High
corticosteroid 2 97.32 Very High Very High Very High
fibrosis 5 89.52 High High
lidocaine 1 65.12 Quite High
beta blocker 3 55.96 Quite High
abdominal pain 1 54.52 Quite High
Osteoarthritis 28 29.96 Quite Low
Pain 11 25.36 Quite Low
depression 11 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 6 99.58 Very High Very High Very High
Diabetes Mellitus 101 99.28 Very High Very High Very High
INFLAMMATION 10 98.68 Very High Very High Very High
Toxicity 6 97.78 Very High Very High Very High
Myocardial Infarction 3 94.68 High High
Adult Respiratory Distress Syndrome 2 90.40 High High
Fibrosis 2 89.52 High High
Body Weight 3 84.40 Quite High
Hypoglycemia 20 82.88 Quite High
Weight Gain 7 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore it would be important that patients failing metformin therapy receive additional antihyperglycemic agents to reduce A1C and minimize the risk of cardiovascular events.
Negative_regulation (reduce) of A1C
1) Confidence 0.13 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2600631 Disease Relevance 1.46 Pain Relevance 0.05
Pulmonary toxicity is usually attributed to direct cytotoxic damage and an indirect immune reaction due to an amiodarone-induced inhibition of phospholipase A.
Negative_regulation (inhibition) of phospholipase associated with toxicity
2) Confidence 0.08 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2194711 Disease Relevance 0.74 Pain Relevance 0.11
We conclude that the lipid A moiety of LPS mediates direct, complement-independent endothelial cell cytotoxicity and that this injury is not prevented by inhibitors of protein and prostaglandin synthesis, oxygen radical production, protease and phospholipase activity, and cytoskeletal function.
Negative_regulation (inhibitors) of phospholipase in endothelial cell associated with injury
3) Confidence 0.05 Published 1983 Journal Lab. Invest. Section Abstract Doc Link 6827807 Disease Relevance 0.30 Pain Relevance 0.07
Decreasing elevated BP, LDL, and A1C in patients with type 2 diabetes reduces the risk of cardiovascular and microvascular events by about 50 percent[18].
Negative_regulation (Decreasing) of A1C associated with diabetes mellitus
4) Confidence 0.04 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1559691 Disease Relevance 0.76 Pain Relevance 0
Inhibition of oxalate damage to kidneys in animal models was attributed to the antioxidant qualities of Fucus-derived fucoidan.21 Fucoidans have been shown to inhibit phospholipase A222 an important enzyme in the inflammatory cascade inhibited by corticosteroids.
Negative_regulation (inhibit) of phospholipase associated with corticosteroid and inflammation
5) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846142 Disease Relevance 0.56 Pain Relevance 0.22

General Comments

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