INT45981

Context Info Confidence 0.13 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.83 Pain Relevance 0.45

cytoplasm (HRASLS)

Anatomy Link Frequency endothelial cell 1 HRASLS (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 9 98.68 corticosteroid 2 97.32 fibrosis 5 89.52 lidocaine 1 65.12 beta blocker 3 55.96 abdominal pain 1 54.52 Osteoarthritis 28 29.96 Pain 11 25.36 depression 11 5.00 alcohol 8 5.00

Disease Link Frequency Relevance Heat Injury 6 99.58 Diabetes Mellitus 101 99.28 INFLAMMATION 10 98.68 Toxicity 6 97.78 Myocardial Infarction 3 94.68 Adult Respiratory Distress Syndrome 2 90.40 Fibrosis 2 89.52 Body Weight 3 84.40 Hypoglycemia 20 82.88 Weight Gain 7 70.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore it would be important that patients failing metformin therapy receive additional antihyperglycemic agents to reduce A1C and minimize the risk of cardiovascular events.

Negative_regulation (reduce) of A1C

1) Confidence 0.13 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2600631 Disease Relevance 1.46 Pain Relevance 0.05

Pulmonary toxicity is usually attributed to direct cytotoxic damage and an indirect immune reaction due to an amiodarone-induced inhibition of phospholipase A.

Negative_regulation (inhibition) of phospholipase associated with toxicity

2) Confidence 0.08 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2194711 Disease Relevance 0.74 Pain Relevance 0.11

We conclude that the lipid A moiety of LPS mediates direct, complement-independent endothelial cell cytotoxicity and that this injury is not prevented by inhibitors of protein and prostaglandin synthesis, oxygen radical production, protease and phospholipase activity, and cytoskeletal function.

Negative_regulation (inhibitors) of phospholipase in endothelial cell associated with injury

3) Confidence 0.05 Published 1983 Journal Lab. Invest. Section Abstract Doc Link 6827807 Disease Relevance 0.30 Pain Relevance 0.07

Decreasing elevated BP, LDL, and A1C in patients with type 2 diabetes reduces the risk of cardiovascular and microvascular events by about 50 percent[18].

Negative_regulation (Decreasing) of A1C associated with diabetes mellitus

4) Confidence 0.04 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1559691 Disease Relevance 0.76 Pain Relevance 0

Inhibition of oxalate damage to kidneys in animal models was attributed to the antioxidant qualities of Fucus-derived fucoidan.21 Fucoidans have been shown to inhibit phospholipase A222 an important enzyme in the inflammatory cascade inhibited by corticosteroids.

Negative_regulation (inhibit) of phospholipase associated with corticosteroid and inflammation

5) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846142 Disease Relevance 0.56 Pain Relevance 0.22

General Comments

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