INT46

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 233
Total Number 235
Disease Relevance 46.15
Pain Relevance 62.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 21
kidney 17
blood 16
brain 7
heart 6
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 165 100.00 Very High Very High Very High
cva 56 100.00 Very High Very High Very High
Catecholamine 25 100.00 Very High Very High Very High
Clonidine 310 99.92 Very High Very High Very High
agonist 193 99.92 Very High Very High Very High
bradykinin 43 99.92 Very High Very High Very High
Angina 3 99.84 Very High Very High Very High
cocaine 91 99.82 Very High Very High Very High
Calcitonin gene-related peptide 12 99.76 Very High Very High Very High
Intracerebroventricular 35 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 416 100.00 Very High Very High Very High
Stress 107 100.00 Very High Very High Very High
Natriuresis 27 100.00 Very High Very High Very High
Hypoaldosteronism 1 100.00 Very High Very High Very High
Cancer 31 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 8 99.96 Very High Very High Very High
Wilms Tumor 2 99.96 Very High Very High Very High
Hypotension 45 99.90 Very High Very High Very High
Cv General 3 Under Development 18 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 43 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renin release by renin-depleted rats following hypotensive haemorrhage and anesthetics.
Localization (release) of Renin associated with hypotension and cva
1) Confidence 0.81 Published 1981 Journal Pflugers Arch. Section Title Doc Link 7033921 Disease Relevance 0.44 Pain Relevance 0.31
Such renin depleted rats were incapable of releasing renin (as judged by increase in plasma renin level) in response to severely hypotensive haemorrhage and had very blunted renin release responses to pentobarbital and urethane anesthesia (59 and 17% of normal respectively). 3.
Localization (releasing) of renin in plasma associated with anesthesia, hypotension and cva
2) Confidence 0.81 Published 1981 Journal Pflugers Arch. Section Abstract Doc Link 7033921 Disease Relevance 0.43 Pain Relevance 0.23
The marked resistance of recovery animals to a second bout of acute renal failure thus cannot be attributed to impaired renin release or inadequate plasma renin substrate.
Localization (release) of renin in plasma associated with acute renal failure
3) Confidence 0.81 Published 1978 Journal Nephron Section Abstract Doc Link 745630 Disease Relevance 0.56 Pain Relevance 0.12
The marked resistance of recovery animals to a second bout of acute renal failure thus cannot be attributed to impaired renin release or inadequate plasma renin substrate.
Localization (release) of renin in plasma associated with acute renal failure
4) Confidence 0.81 Published 1978 Journal Nephron Section Abstract Doc Link 745630 Disease Relevance 0.56 Pain Relevance 0.12
Renin release and the refractoriness to acute renal failure of rats recovering from prior renal failure.
Localization (release) of Renin associated with acute renal failure, renal failure and cva
5) Confidence 0.81 Published 1978 Journal Nephron Section Title Doc Link 745630 Disease Relevance 0.52 Pain Relevance 0.17
Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg weight blood or subcutaneous administration of 500 microgram/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats).
Localization (release) of renin in blood associated with acute renal failure and body weight
6) Confidence 0.81 Published 1978 Journal Nephron Section Abstract Doc Link 745630 Disease Relevance 0.45 Pain Relevance 0.10
Renin release by pentobarbital anesthesia in the rat: a role for vascular mechanisms.
Localization (release) of Renin associated with anesthesia
7) Confidence 0.81 Published 1982 Journal Life Sci. Section Title Doc Link 7040889 Disease Relevance 0.17 Pain Relevance 0.56
However, renin hypersecretion may be important in the early pre-hypertensive stage of genetic hypertension in rats.
Localization (hypersecretion) of renin associated with hypertension
8) Confidence 0.81 Published 1976 Journal Clin Sci Mol Med Section Abstract Doc Link 1253523 Disease Relevance 1.09 Pain Relevance 0.07
Sodium chloride suppression of renin release in the unanesthetized rat.
Localization (release) of renin
9) Confidence 0.81 Published 1975 Journal Endocrinology Section Title Doc Link 1204570 Disease Relevance 0 Pain Relevance 0.25
We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release.
Localization (secretion) of renin in renal nerve associated with tetrodotoxin
10) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.21
These results suggest that the reduction of blood pressure in two-kidney, one-clip hypertensive rats may be due to reduced renin release through the action of clonidine, while in one-kidney, one-clip hypertensive rats the sympathetic nervous activity may play little or no role in the maintenance of high blood pressure.
Localization (release) of renin in kidney associated with hypertension and clonidine
11) Confidence 0.81 Published 1983 Journal Chest Section Abstract Doc Link 6337027 Disease Relevance 0.62 Pain Relevance 0.30
These results are consistent with the hypothesis that veratrine stimulates renin secretion by at least two mechanisms.
Localization (secretion) of renin
12) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.20
Moreover, veratrine stimulated renin secretion in slices prepared from previously denervated kidneys; this response was not antagonized by timolol.
Localization (secretion) of renin
13) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.20
It is well known that norepinephrine released from the renal nerves stimulates the secretion of renin by a beta adrenergic mechanism.
Localization (secretion) of renin in renal nerves
14) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.10
In the present experiments, we investigated the effects of renin secretion of veratrine, which depolarizes nerve terminals and thereby causes transmitter release.
Localization (secretion) of renin in nerve
15) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.11
Action and mechanism of action of veratrine on renin secretion from rat kidney slices.
Localization (secretion) of renin in kidney
16) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.17
In this study, we evaluated the effects of the rat submandibular gland extract and of some plasma active renin stimulants on inactive renin release from rat renal cortical slices.
Localization (release) of renin in submandibular gland
17) Confidence 0.81 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 2118863 Disease Relevance 0 Pain Relevance 0.09
The rat submandibular gland extract (100 microliters) did not affect the release of active renin but stimulated the release of inactive renin significantly (p less than 0.05 vs. control).
Localization (release) of renin in submandibular gland
18) Confidence 0.81 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 2118863 Disease Relevance 0 Pain Relevance 0
Veratrine (10-200 microM) stimulated renin secretion in a concentration-dependent manner.
Localization (secretion) of renin
19) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.13
We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release.
Localization (secretion) of renin in renal nerve associated with tetrodotoxin
20) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.19

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