INT460

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.85
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Atxn2) nucleus (Atxn2) cytoplasm (Atxn2)
Anatomy Link Frequency
muscle 1
Atxn2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.78 Very High Very High Very High
Action potential 6 94.48 High High
tetrodotoxin 7 94.32 High High
long-term potentiation 26 81.68 Quite High
amygdala 21 80.80 Quite High
Hippocampus 12 78.32 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 11 97.48 Very High Very High Very High
Neurodegenerative Disease 2 90.24 High High
Congenital Anomalies 7 86.64 High High
Disease 2 83.40 Quite High
Hyperkinesis 7 74.80 Quite High
Anxiety Disorder 47 71.20 Quite High
Targeted Disruption 20 58.44 Quite High
Appetite Loss 13 19.52 Low Low
Shock 18 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Delineating behavioral consequences of Atxn2 deficiency in the mouse is thus important for understanding pathology in SCA2 patients and selective forces in Northern Europeans.
Negative_regulation (deficiency) of Atxn2 associated with spinocerebellar ataxia type 2
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.85 Pain Relevance 0.25
The effects on muscle are due to a Na+ channel specific action of ATX II.
Negative_regulation (action) of ATX II in muscle
2) Confidence 0.33 Published 1984 Journal Toxicon Section Abstract Doc Link 6147908 Disease Relevance 0 Pain Relevance 0.35
The rise of cGMP due to ATX II, MCD-peptide and high potassium was diminished when Na+ had been replaced by Li+. 2.
Negative_regulation (diminished) of ATX II
3) Confidence 0.30 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 39260 Disease Relevance 0 Pain Relevance 0.28
The so-called Ca2+-antagonist (-)-D-600 blocked the increase of cGMP due to ATX II, MCD-peptide, veratridine and high potassium. 5.
Negative_regulation (blocked) of ATX II associated with antagonist
4) Confidence 0.30 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 39260 Disease Relevance 0 Pain Relevance 0.33

General Comments

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