INT46016

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Context Info
Confidence 0.77
First Reported 1983
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 69
Total Number 72
Disease Relevance 41.22
Pain Relevance 19.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
neurons 9
brain 4
nerve 4
sensory neurons 3
epithelium 3
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 21 100.00 Very High Very High Very High
neuralgia 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 99.90 Very High Very High Very High
Pain 59 99.80 Very High Very High Very High
substance P 36 99.80 Very High Very High Very High
Chronic pancreatitis 16 99.80 Very High Very High Very High
Nerve growth factor 146 99.72 Very High Very High Very High
Sciatic nerve 64 99.58 Very High Very High Very High
c fibre 1 99.58 Very High Very High Very High
cINOD 96 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 830 100.00 Very High Very High Very High
Cancer 76 100.00 Very High Very High Very High
Neuroblastoma 8 99.86 Very High Very High Very High
Apoptosis 1672 99.84 Very High Very High Very High
Pain 76 99.80 Very High Very High Very High
Pancreatitis 16 99.80 Very High Very High Very High
Nervous System Injury 18 99.70 Very High Very High Very High
Drug Induced Neurotoxicity 40 99.68 Very High Very High Very High
Toxicity 148 99.66 Very High Very High Very High
Bladder Cancer 8 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of these neurons also co-express the neurotrophin receptor p75 (p75NTR), but its function has remained obscure.
Gene_expression (co-express) of p75NTR in neurons
1) Confidence 0.77 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466406 Disease Relevance 0.08 Pain Relevance 0.27
Application of the p75 NTR inhibitory antibody to the pinched sciatic nerve suppressed CGRP and p75 NTR expression and pain behavior.
Gene_expression (expression) of p75 in sciatic nerve associated with pain, sciatic nerve and calcitonin gene-related peptide
2) Confidence 0.77 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.60 Pain Relevance 0.97
CGRP and p75 NTR expression in L5 dorsal root ganglions (DRGs) was examined immunohistochemically.
Gene_expression (expression) of p75 in dorsal root ganglions associated with ganglion cysts and calcitonin gene-related peptide
3) Confidence 0.77 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.61 Pain Relevance 0.96
CGRP and p75 NTR immunoreactivity in the L5 DRG neurons was upregulated in the injured nerve groups compared with the sham-operated group; however, p75 NTR inhibitory antibody decreased the CGRP and p75 NTR expression (p < 0.01).
Gene_expression (expression) of p75 in nerve associated with calcitonin gene-related peptide
4) Confidence 0.77 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.53 Pain Relevance 1.00
Expression of the low affinity p75 neutrophin receptor (p75(NTR)) was twofold higher in the myometrium compared with luminal epithelium or stroma.
Gene_expression (Expression) of p75 in epithelium
5) Confidence 0.74 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 12580757 Disease Relevance 0.16 Pain Relevance 0.54
There was no detectable expression of high affinity tyrosine kinase receptor (trkA(NGFR)).
Neg (no) Gene_expression (expression) of NGFR
6) Confidence 0.74 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 12580757 Disease Relevance 0.14 Pain Relevance 0.54
Expression of the low affinity p75 neutrophin receptor (p75(NTR)) was twofold higher in the myometrium compared with luminal epithelium or stroma.
Gene_expression (Expression) of p75 in epithelium
7) Confidence 0.74 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 12580757 Disease Relevance 0.16 Pain Relevance 0.54
However, we did not observe any reduction in the number of neurons expressing p75NTR in Necdin embryonic DRGs compared to wild type.
Gene_expression (expressing) of p75NTR in neurons
8) Confidence 0.73 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.48 Pain Relevance 0
Furthermore, throughout development, Necdin and p75NTR expression partially overlaps in the post-mitotic territories [16].
Gene_expression (expression) of p75NTR
9) Confidence 0.73 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.44 Pain Relevance 0
Colabelling results showed that p75NTR is expressed only in a subset of sensory neurons (Islet1/2-positive), in a subpopulation of Necdin expressing neurons and more particularly in 40% of proprioceptive (TrkC) neurons (Runx3-positive).
Gene_expression (expressed) of p75NTR in sensory neurons
10) Confidence 0.73 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.29 Pain Relevance 0
We then compared the number of cells expressing p75NTR in the lumbar DRGs of wild type and Necdin mutant.
Gene_expression (expressing) of p75NTR
11) Confidence 0.73 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.11 Pain Relevance 0
Nerve injury increased the expression and axonal transport of p75NTR and phosphorylation of TrkA in the uninjured primary afferents.
Gene_expression (expression) of p75NTR in Nerve associated with nervous system injury
12) Confidence 0.72 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 0.96 Pain Relevance 0.57
Most of these neurons also co-express the neurotrophin receptor p75 (p75NTR), but its function has remained obscure.
Gene_expression (co-express) of neurotrophin receptor p75 in neurons
13) Confidence 0.68 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466406 Disease Relevance 0.08 Pain Relevance 0.27
The receptive properties of large myelinated afferent fibers were normal in p75-/- mice.
Gene_expression (normal) of p75
14) Confidence 0.67 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9151756 Disease Relevance 0.28 Pain Relevance 0.20
In contrast in chronic pancreatitis moderate p75NTR expression was present in acinar cells next to fibrosis, ductal cells, and cells of ductular structures as well as in some islet cells.
Gene_expression (expression) of p75NTR in acinar cells associated with fibrosis and chronic pancreatitis
15) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741461 Disease Relevance 1.17 Pain Relevance 0.71
In situ hybridization revealed weak p75NTR mRNA expression in some ductal cells in the normal pancreas.
Gene_expression (expression) of p75NTR in pancreas
16) Confidence 0.66 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741461 Disease Relevance 1.11 Pain Relevance 0.66
The following in situ probes were used: Trka, Trkb and Trkc (a gift from Patapoutian), Islet [40], Ndn [16], p75NTR (a gift from Dechant).
Gene_expression (used) of p75NTR
17) Confidence 0.64 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0 Pain Relevance 0
Indeed, these results show that cell death observed in Necdin mutant DRGs does not affect specifically the p75NTR-expressing neurons and consequently does not directly involve the p75NTR-signalling pathway.


Gene_expression (neurons) of p75NTR-expressing in neurons associated with death
18) Confidence 0.64 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.10 Pain Relevance 0
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
Gene_expression (Suppression) of p75 neurotrophin receptor in sensory neurons associated with neuralgia, nervous system injury and neuropathic pain
19) Confidence 0.62 Published 2006 Journal J. Neurosci. Section Title Doc Link 17108171 Disease Relevance 0.90 Pain Relevance 0.83
It may thus be suggested that neurotrophin presenting p75 positive cells could facilitate axonal growth into the pia mater and that the lack of such cells in the CNS compartment might contribute to the failure of growth into the CNS.
Gene_expression (presenting) of p75 in pia mater
20) Confidence 0.60 Published 2010 Journal Frontiers in Neurology Section Abstract Doc Link PMC3008941 Disease Relevance 0.42 Pain Relevance 0.19

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