INT46036

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Context Info
Confidence 0.39
First Reported 1983
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALAS1) small molecule metabolic process (ALAS1) nucleolus (ALAS1)
biosynthetic process (ALAS1) nucleus (ALAS1) transferase activity, transferring acyl groups (ALAS1)
Anatomy Link Frequency
embryo 1
ALAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 5 99.04 Very High Very High Very High
Lamotrigine 5 98.36 Very High Very High Very High
anticonvulsant 9 90.88 High High
lidocaine 1 55.60 Quite High
Morphine 1 33.52 Quite Low
algil 1 30.40 Quite Low
Disease Link Frequency Relevance Heat
Porphyria 4 78.40 Quite High
Acute Intermittent Porphyria 2 75.00 Quite High
Hepatic Porphyrias 2 25.00 Low Low
Convulsion 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of some anaesthetic drugs on the activity of delta-aminolevulinate synthetase and on the formation of porphyrins and cytochrome P-450 were studied in 18-day-old chick embryo livers in ovo.
Regulation (Effects) of delta-aminolevulinate synthetase in embryo
1) Confidence 0.39 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6838647 Disease Relevance 0.15 Pain Relevance 0.06
In the presence of deferoxamine, phenobarbital, felbamate, lamotrigine, or tiagabine, but not gabapentin or vigabatrin, increased levels of the mRNA of ALA synthase, the first and rate-controlling enzyme of porphyrin synthesis.
Neg (not) Regulation (rate-controlling) of ALA synthase associated with lamotrigine and gabapentin
2) Confidence 0.33 Published 1997 Journal Neurology Section Abstract Doc Link 9222176 Disease Relevance 0.07 Pain Relevance 0.67

General Comments

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