INT46038

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALAS1) small molecule metabolic process (ALAS1) nucleolus (ALAS1)
biosynthetic process (ALAS1) nucleus (ALAS1) transferase activity, transferring acyl groups (ALAS1)
ALAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 5 99.68 Very High Very High Very High
Lamotrigine 5 99.00 Very High Very High Very High
lidocaine 1 97.98 Very High Very High Very High
anticonvulsant 9 92.16 High High
Morphine 1 89.84 High High
algil 1 86.72 High High
anesthesia 1 66.16 Quite High
alcohol 2 25.00 Low Low
withdrawal 1 25.00 Low Low
opiate 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Porphyria 14 97.98 Very High Very High Very High
Acute Intermittent Porphyria 2 75.00 Quite High
Congenital Anomalies 2 71.88 Quite High
Disease 4 69.68 Quite High
Rare Diseases 1 54.72 Quite High
Erythropoietic Porphyria 1 45.84 Quite Low
Hepatic Porphyrias 2 25.00 Low Low
Convulsion 2 25.00 Low Low
Infection 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, lidocaine and its derivatives (bupivacaine, mepivacaine, etidocaine, pyrrocaine and prilocaine) were found to induce delta-aminolevulinate synthetase and to cause accumulation of porphyrins and cytochrome P-450.
Positive_regulation (induce) of delta-aminolevulinate synthetase associated with lidocaine
1) Confidence 0.60 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6838647 Disease Relevance 0.17 Pain Relevance 0.27
In the presence of deferoxamine, phenobarbital, felbamate, lamotrigine, or tiagabine, but not gabapentin or vigabatrin, increased levels of the mRNA of ALA synthase, the first and rate-controlling enzyme of porphyrin synthesis.
Positive_regulation (increased) of ALA synthase associated with lamotrigine and gabapentin
2) Confidence 0.51 Published 1997 Journal Neurology Section Abstract Doc Link 9222176 Disease Relevance 0.07 Pain Relevance 0.66
The enzyme deficiency that occurs in porphyrias is responsible for reduced haeme production, which, in turn, allows the cascade to be stimulated by increased activity of the trigger enzyme, ALA-synthase (ALA-s).
Positive_regulation (increased) of ALA-synthase associated with porphyria
3) Confidence 0.29 Published 2002 Journal G Ital Nefrol Section Abstract Doc Link 12369042 Disease Relevance 0.65 Pain Relevance 0.07

General Comments

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