INT46044

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1983
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 20.07
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
jejunum 4
HPAF-II 4
small intestine 4
plasma 2
intestines 2
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 94.20 High High
Pain 8 93.84 High High
Inflammation 195 91.44 High High
Inflammatory response 68 89.64 High High
ischemia 192 81.28 Quite High
fortral 2 77.16 Quite High
Inflammatory marker 8 71.12 Quite High
cytokine 47 46.40 Quite Low
tolerance 35 37.44 Quite Low
cINOD 3 31.04 Quite Low
Disease Link Frequency Relevance Heat
Dengue 728 100.00 Very High Very High Very High
Flavivirus Infection 560 100.00 Very High Very High Very High
Thrombocytopenia 59 99.96 Very High Very High Very High
Infection 284 99.88 Very High Very High Very High
Hemolytic Uremic Syndrome 30 99.60 Very High Very High Very High
Insulin Resistance 46 99.28 Very High Very High Very High
Hemolytic Anemia 1 99.22 Very High Very High Very High
Metabolic Syndrome 2 97.48 Very High Very High Very High
Clostridium Infection 5 96.48 Very High Very High Very High
Hypertension 8 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of activated complement components as well as a clear increase in local C3 mRNA expression levels may illustrate the intestines response aimed at protection and preservation.
Spec (clear) Positive_regulation (increase) of Gene_expression (expression) of C3 mRNA in intestines
1) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.33 Pain Relevance 0.08
Interestingly, our results do however suggest C3 gene expression in healthy jejunum tissue as well as an increased synthesis of C3 in response to IR.
Positive_regulation (increased) of Gene_expression (synthesis) of C3 in jejunum
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.35 Pain Relevance 0.08
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Positive_regulation (elevated) of Gene_expression (level) of C3 associated with hemolytic anemia and thrombocytopenia
3) Confidence 0.40 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.57 Pain Relevance 0.09
The ability of small intestinal epithelial cells to express biological mediators such as C3 in response to IR was to be expected since previous work demonstrated C3 gene expression in inflamed small intestine.[37] To the best of our knowledge, however, these are the first results that demonstrate C3 mRNA expression in the healthy jejunum.
Positive_regulation (demonstrated) of Gene_expression (expression) of C3 in small intestine
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.24 Pain Relevance 0.07
Interestingly, our results do however suggest C3 gene expression in healthy jejunum tissue as well as an increased synthesis of C3 in response to IR.
Spec (suggest) Positive_regulation (suggest) of Gene_expression (expression) of C3 in jejunum
5) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.36 Pain Relevance 0.09
The ability of small intestinal epithelial cells to express biological mediators such as C3 in response to IR was to be expected since previous work demonstrated C3 gene expression in inflamed small intestine.[37] To the best of our knowledge, however, these are the first results that demonstrate C3 mRNA expression in the healthy jejunum.
Positive_regulation (demonstrate) of Gene_expression (expression) of C3 mRNA in small intestine
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.19 Pain Relevance 0.06
and C3 gene expression were up-regulated during reperfusion.
Positive_regulation (up-regulated) of Gene_expression (expression) of C3
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.49 Pain Relevance 0.16
0.005) increase in the C3 levels of the DHF patients after they recovered from the acute infection, and these levels were not significantly different from the levels found in control patients, confirming that the C3 was consumed at higher levels in DHF patients than in DF patients during the acute stage of the dengue infection.
Positive_regulation (increase) of Gene_expression (levels) of C3 associated with flavivirus infection, dengue and infection
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.60 Pain Relevance 0
In addition, clinical studies have shown that the levels of dengue NS1 and products of complement activation, including those with a known vascular effect, such as C3a, C5a, and sC5b-9, are present in higher levels in DHF patients before plasma leakage takes place, supporting the theory that complement activation is involved in the development of severe disease [12] and to deleterious patient outcomes [11], [13], [14].
Positive_regulation (activation) of Gene_expression (levels) of C3a in plasma associated with flavivirus infection, dengue and disease
9) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.03 Pain Relevance 0
In order to determine whether the lower levels of C3 were indeed the result of high levels of complement system activity during infection, the C3 levels of the DHF patients were also measured during the convalescent phase (Figure 1B).
Positive_regulation (measured) of Gene_expression (levels) of C3 associated with flavivirus infection and infection
10) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.52 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (consumption) of Gene_expression (production) of C3a associated with flavivirus infection
11) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.02 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (increased) of Gene_expression (production) of C3a associated with flavivirus infection
12) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.01 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (increased) of Gene_expression (production) of C3 associated with flavivirus infection
13) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.02 Pain Relevance 0
DHF patients have elevated levels of the anaphylotoxins C3a and C5a
Positive_regulation (elevated) of Gene_expression (levels) of C3a associated with flavivirus infection
14) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.75 Pain Relevance 0
Serum C3 and C4 levels (mean +/- SD, mg/dl) were elevated at the 1st day in AMI as well as AP patients (C3 --> AMI1: 154.0 +/- 28.5, AP1: 152.0 +/- 45.0, CS: 132.0 +/- 8.0, ANOVA: p = 0.0072; C4 --> AMII1: 38 +/- 13, AP1: 37 +/- 17, CS: 29 +/- 6, ANOVA: p = 0.0160).
Positive_regulation (elevated) of Gene_expression (levels) of C3
15) Confidence 0.23 Published 2007 Journal Bangladesh Med Res Counc Bull Section Abstract Doc Link 18783065 Disease Relevance 0.41 Pain Relevance 0.17
Serum studies showed decreased levels of C3, elevated levels of IgM (greater than 2 SD) (three patients) and circulating immune complexes (two patients).
Positive_regulation (elevated) of Gene_expression (levels) of C3
16) Confidence 0.20 Published 1983 Journal Clin. Nephrol. Section Abstract Doc Link 6839565 Disease Relevance 0.41 Pain Relevance 0.08
Levels of C3 and fB were higher in subjects with insulin resistance and other features of the metabolic syndrome (28,29).
Positive_regulation (higher) of Gene_expression (Levels) of C3 associated with metabolic syndrome and insulin resistance
17) Confidence 0.17 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.56 Pain Relevance 0.08
There is also a correlation between increased C3 concentration and decreased insulin action (26,27).
Positive_regulation (increased) of Gene_expression (concentration) of C3
18) Confidence 0.16 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.55 Pain Relevance 0.07
For completeness, we performed a multivariate analysis with ESR, anti-dsDNA level, C3 level, and C4 level included in the same regression model.
Positive_regulation (multivariate) of Gene_expression (level) of C3
19) Confidence 0.15 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.49 Pain Relevance 0
Patients with atypical HUS should, therefore, undergo complement factor determination (C3, factor H, factor I, factor B, and MCP expression), genotyping (factor H, factor H-linked genes, factor I, MCP, factor B and C3) and determination of anti-factor H antibodies prior to renal Tx so that the risk of graft failure can be evaluated [6].
Positive_regulation (undergo) of Spec (determination) Gene_expression (expression) of C3 associated with hemolytic uremic syndrome
20) Confidence 0.13 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 1.94 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox