INT46045

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Context Info
Confidence 0.30
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.15
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 98.76 Very High Very High Very High
abdominal pain 1 98.72 Very High Very High Very High
cytokine 4 98.12 Very High Very High Very High
fortral 2 77.56 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Flavivirus Infection 80 99.68 Very High Very High Very High
Periodontitis 16 99.16 Very High Very High Very High
INFLAMMATION 37 98.76 Very High Very High Very High
Abdominal Pain 1 98.72 Very High Very High Very High
Pressure And Volume Under Development 1 97.96 Very High Very High Very High
Disease 20 96.96 Very High Very High Very High
Hereditary Angioedema 2 96.08 Very High Very High Very High
Injury 1 90.96 High High
Infection 47 89.88 High High
Targeted Disruption 2 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They found that levels of C3 were reduced in all DHF patients, and observed a correlation between C3 consumption and disease severity.
Negative_regulation (reduced) of Gene_expression (levels) of C3 associated with flavivirus infection and disease
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.44 Pain Relevance 0
Serum studies showed decreased levels of C3, elevated levels of IgM (greater than 2 SD) (three patients) and circulating immune complexes (two patients).
Negative_regulation (decreased) of Gene_expression (levels) of C3
2) Confidence 0.17 Published 1983 Journal Clin. Nephrol. Section Abstract Doc Link 6839565 Disease Relevance 0.41 Pain Relevance 0.08
As these cytokines were expressed within normal range in periodontitis sites following periodontal therapy, the decreased expression of C3 may further indicate a normal inflammatory status that is reached following periodontal therapy.
Negative_regulation (decreased) of Gene_expression (expression) of C3 associated with periodontitis, inflammation and cytokine
3) Confidence 0.12 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.70 Pain Relevance 0.28
Direct inactivation of C3 convertases
Negative_regulation (inactivation) of Gene_expression (convertases) of C3
4) Confidence 0.09 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.24 Pain Relevance 0
Laboratory examination showed reduced levels of CH50 and C4 with a normal C3 level.
Negative_regulation (reduced) of Gene_expression (levels) of C3
5) Confidence 0.09 Published 2004 Journal Intern. Med. Section Abstract Doc Link 15098611 Disease Relevance 0.37 Pain Relevance 0.10

General Comments

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