INT4605

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 220
Total Number 224
Disease Relevance 139.66
Pain Relevance 10.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 32
beta cell 18
blood 14
pancreas 14
fat 6
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 825 100.00 Very High Very High Very High
tolerance 525 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
Angina 42 99.90 Very High Very High Very High
cytokine 311 99.82 Very High Very High Very High
anesthesia 131 99.60 Very High Very High Very High
Bile 27 99.48 Very High Very High Very High
agonist 45 99.44 Very High Very High Very High
Catecholamine 47 99.06 Very High Very High Very High
Chronic pancreatitis 6 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8407 100.00 Very High Very High Very High
Hypoglycemia 1786 100.00 Very High Very High Very High
Insulin Resistance 1663 100.00 Very High Very High Very High
INFLAMMATION 997 100.00 Very High Very High Very High
Impaired Glucose Tolerance 531 100.00 Very High Very High Very High
Stress 522 100.00 Very High Very High Very High
Death 392 100.00 Very High Very High Very High
Gestational Diabetes 192 100.00 Very High Very High Very High
Weight Loss 189 100.00 Very High Very High Very High
Obesity 3662 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
permanent lack of insulin production from the pancreas due to the destruction
Negative_regulation (lack) of Gene_expression (production) of insulin in pancreas
1) Confidence 0.58 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.30 Pain Relevance 0
The central element in the development and progression of diabetes is the progressive loss of insulin production and/or insulin sensitivity, leading to dysregulation of systemic glucose utilization and increased BG concentrations.
Negative_regulation (loss) of Gene_expression (production) of insulin associated with diabetes mellitus
2) Confidence 0.58 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350138 Disease Relevance 1.41 Pain Relevance 0.07
It was shown that both anesthetics - thalamonal and thiopental - inhibited rates of insulin synthesis and decrease its secretion.
Negative_regulation (inhibited) of Gene_expression (synthesis) of insulin
3) Confidence 0.56 Published 1975 Journal Acta Diabetol Lat Section Abstract Doc Link 1229804 Disease Relevance 0 Pain Relevance 0.31
Endogenous insulin production was suppressed during the 0.6 mU·m?
Negative_regulation (suppressed) of Gene_expression (production) of insulin
4) Confidence 0.53 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
It should be noted that, in spite of the overall initial efficacy in prevention of disease progression, the effects of the therapy varied between individuals (with some patients failing to recover endogenous C-peptide secretion from the beginning of the treatment) and eventually the decline of insulin production was inevitable.
Negative_regulation (decline) of Gene_expression (production) of insulin associated with disease progression
5) Confidence 0.49 Published 2008 Journal Diabetic Medicine Section Body Doc Link PMC2701557 Disease Relevance 0.53 Pain Relevance 0.18
glucose concentration mainly caused by the lack of internal insulin production,
Negative_regulation (lack) of Gene_expression (production) of insulin in internal
6) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.04 Pain Relevance 0
resulting from the permanent lack of insulin production from the pancreas (type
Negative_regulation (lack) of Gene_expression (production) of insulin in pancreas
7) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.78 Pain Relevance 0
Type 2 diabetes is a highly prevalent, progressive disease, characterized by defects in insulin production and utilization and is associated with significant morbidity and mortality.
Negative_regulation (defects) of Gene_expression (production) of insulin associated with diabetes mellitus and disease
8) Confidence 0.43 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.82 Pain Relevance 0
Attempts to overcome these problems have been made by other companies that are developing their own versions of inhaled insulin and promising results regarding patientsÂ’ acceptance are beginning to emerge.13
Negative_regulation (developing) of Gene_expression (versions) of insulin
9) Confidence 0.43 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915552 Disease Relevance 0.29 Pain Relevance 0.03
With insulin lispro, the metabolic changes developed 1.5 to 2 hours earlier than with regular human insulin (after 3 hours: difference in base excess (BE) mean +/- SD: regular human insulin: -0.41 +/- 1.04 mmol/l; insulin lispro: -1.69 +/- 0.83 mmol/l, p < 0.05; blood glucose: regular human insulin: 4.93 +/- 2.87 mmol/l, insulin lispro: 8.97 +/- 3.48, p < 0.05; pH values: regular human insulin: 7.38 +/- 0.02, insulin lispro: 7.36 +/- 0.02, n.s.).
Negative_regulation (developed) of Gene_expression (lispro) of insulin in blood
10) Confidence 0.43 Published 1998 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 9710355 Disease Relevance 0.28 Pain Relevance 0
Inhalation anesthesia alone was found to suppress basal insulin levels and the insulin response to intravenous glucose with no significant increase in plasma norepinephrine and a decrease in plasma epinephrine.
Negative_regulation (suppress) of Gene_expression (levels) of insulin in plasma associated with anesthesia
11) Confidence 0.43 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.60 Pain Relevance 0.55
Diabetic complications have been reduced significantly with the introduction of insulin more than 8 decades prior.
Negative_regulation (reduced) of Gene_expression (introduction) of insulin associated with diabetes complications
12) Confidence 0.43 Published 2007 Journal J Clin Pharmacol Section Abstract Doc Link 17585117 Disease Relevance 0.26 Pain Relevance 0.09
It has been reported that insulin resistance is associated with adiposity, particularly that which is centrally deposited, which is metabolically more active than that which is peripherally deposited.3,4 Insulin resistance is also associated with hypertension and dyslipidemia (increased triglyceride and decreased HDL cholesterol levels) in type 2 diabetic subjects.4-7
Negative_regulation (deposited.3,4) of Gene_expression (resistance) of Insulin associated with diabetes mellitus, hypertension, insulin resistance and disorder of lipid metabolism
13) Confidence 0.43 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 1.67 Pain Relevance 0
A second, large, open-label study confirms that initiating insulin therapy in type 2 diabetes with biphasic insulin aspart may reduce HbA1c and mean PPG increment to a greater extent than initiating insulin glargine.
Negative_regulation (reduce) of Gene_expression (therapy) of insulin associated with diabetes mellitus
14) Confidence 0.43 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.39 Pain Relevance 0
Safety profile of insulin detemir
Negative_regulation (profile) of Gene_expression (detemir) of insulin
15) Confidence 0.43 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0.15 Pain Relevance 0.03
Barriers to the initiation of insulin therapy
Negative_regulation (initiation) of Gene_expression (therapy) of insulin
16) Confidence 0.43 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0.69 Pain Relevance 0.11
Inhaled insulin products such as Exubera are an exciting development in the management of diabetes since they potentially avoid and certainly reduce the need for subcutaneous injections while providing a physiologic response to postprandial glucose.
Negative_regulation (development) of Gene_expression (products) of insulin associated with diabetes mellitus
17) Confidence 0.43 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.62 Pain Relevance 0
Compared with metformin plus a sulfonylurea, inhaled insulin in combination with a sulfonylurea produced a significantly greater reduction in HbA1c in patients with a baseline HbA1c value >9.5%.
Negative_regulation (reduction) of Gene_expression (produced) of insulin
18) Confidence 0.43 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.38 Pain Relevance 0
Diabetes mellitus represents a heterogeneous group of metabolic disorders which are characterized by hyperglycemia as a result of severe insulin deficiency (type 1 diabetes) or defects in insulin resistance, impaired insulin secretion, and increased glucose production (type 2 diabetes).
Negative_regulation (defects) of Gene_expression (resistance) of insulin associated with hyperglycemia, metabolic disorder, diabetes mellitus and insulin resistance
19) Confidence 0.43 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 2.06 Pain Relevance 0
The authors concluded that biphasic insulin lispro 25/75 was a more effective treatment option because it resulted in a greater decrease in HbA1c levels, a higher number of HbA1c ?
Negative_regulation (option) of Gene_expression (lispro) of insulin
20) Confidence 0.43 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.36 Pain Relevance 0

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