INT46053

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Context Info
Confidence 0.08
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
cardiomyocyte 1
brainstem 1
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.84 Very High Very High Very High
electroacupuncture 5 99.82 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.76 Very High Very High Very High
medulla 4 97.96 Very High Very High Very High
narcan 2 92.16 High High
antagonist 1 91.76 High High
opiate 1 91.32 High High
Central nervous system 1 82.04 Quite High
Nerve growth factor 1 77.28 Quite High
ischemia 1 75.28 Quite High
Disease Link Frequency Relevance Heat
Death 15 99.04 Very High Very High Very High
Hypertension 2 96.88 Very High Very High Very High
Body Weight 2 87.28 High High
Ataxia 1 80.20 Quite High
Cv Unclassified Under Development 1 75.28 Quite High
Drug Induced Neurotoxicity 5 54.44 Quite High
Bacillus Anthracis Infection 28 50.00 Quite Low
Stress 26 50.00 Quite Low
Apoptosis 2 32.72 Quite Low
INFLAMMATION 20 18.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment.
Neg (unaffected) Regulation (unaffected) of NADPH dehydrogenase associated with morphine
1) Confidence 0.08 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.15
Role of the NADPH oxidase in peroxynitrite formation and oxidative damage
Regulation (Role) of NADPH
2) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.19 Pain Relevance 0.12
Our result suggested a role of NADPH oxidase in lethal toxin-induced cardiomyocyte contractile dysfunction.
Regulation (role) of NADPH in cardiomyocyte
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.16 Pain Relevance 0
The aim of this study was to investigate the electroacupuncture-related changes of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the brainstem of spontaneously hypertensive rats (SHR).
Regulation (changes) of NADPH-d in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
4) Confidence 0.00 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11595335 Disease Relevance 0.17 Pain Relevance 0.29

General Comments

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