INT46054

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Context Info
Confidence 0.65
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 42
Disease Relevance 12.82
Pain Relevance 9.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
brain 6
neurons 4
spinal cord 3
astrocytes 3
cardiomyocyte 2
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 99.78 Very High Very High Very High
tolerance 20 99.70 Very High Very High Very High
cINOD 98 99.62 Very High Very High Very High
Versed 20 99.58 Very High Very High Very High
Morphine 66 99.50 Very High Very High Very High
ketamine 36 99.36 Very High Very High Very High
Nerve growth factor 16 99.32 Very High Very High Very High
antinociception 2 99.14 Very High Very High Very High
Inflammation 207 99.12 Very High Very High Very High
Spinal cord 30 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 970 100.00 Very High Very High Very High
Urological Neuroanatomy 20 99.84 Very High Very High Very High
Injury 46 99.82 Very High Very High Very High
Death 167 99.60 Very High Very High Very High
INFLAMMATION 353 99.50 Very High Very High Very High
Nociception 5 99.44 Very High Very High Very High
Pain 4 98.52 Very High Very High Very High
Cv Unclassified Under Development 23 98.32 Very High Very High Very High
Schizophrenia 14 97.78 Very High Very High Very High
Pathologic Processes 4 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NADPH- Diaphorase histochemistry
Gene_expression (histochemistry) of NADPH
1) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1373636 Disease Relevance 0.15 Pain Relevance 0
The high level of ME-1 expression in liver, and its involvement in NADPH production, suggests reduced ME-1 activity might compromise hepatic production of reduced glutathione (GSH) by the NADPH-dependent enzyme glutathione reductase, and hence affect xenobiotic detoxification.
Gene_expression (production) of NADPH in liver
2) Confidence 0.65 Published 2008 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 18346052 Disease Relevance 0.23 Pain Relevance 0.23
NOX2 is the original member of the NOX family of reactive oxygen species (ROS)-generating NADPH oxidases, which now includes NOX1-NOX5, DUOX1 and DUOX2 [1], [2].
Gene_expression (generating) of NADPH
3) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.09 Pain Relevance 0
Therefore, Nox2 represents the only apocynin-inhibitable NADPH oxidase isoform expressed in aged mouse brain.
Gene_expression (expressed) of NADPH in brain
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Previous studies have reported that Nox2 and Nox4 are the only NADPH oxidase isoforms expressed in the adult mouse nervous system[28], a finding we confirmed by RT-PCR in brain of old mice as well (Dugan and Zheng, unpublished).
Gene_expression (expressed) of NADPH in brain
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Detection of NADPH-dependent superoxide production in synaptosomal preparations was performed using spin-trapping EPR spectroscopy as described[15], [18].
Gene_expression (production) of NADPH
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Therefore, Nox2 represents the only apocynin-inhibitable NADPH oxidase isoform expressed in aged mouse brain.
Gene_expression (expressed) of NADPH in brain
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment.
Gene_expression (levels) of NADPH dehydrogenase associated with morphine
8) Confidence 0.08 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.16
IL-6 injected mice had significantly greater NADPH-dependent oxygen consumption (Fig. 3a, F(1,12)?
Gene_expression (had) of NADPH
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Neuronal cells respond to toxic insults including ischemia [73], zinc overload [72], and nerve growth factor deprivation [71] by inducing the expression and translocation of NADPH oxidase subunits.
Gene_expression (expression) of NADPH in Neuronal associated with nerve growth factor and ischemia
10) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.38 Pain Relevance 0.15
To study the effect of IL-6 on synaptosomal Nox2 activity, we measured NADPH-driven O2 consumption and superoxide production in young mice 16 hours after repeated injection of either saline or IL-6 (5 µg/kg, i.p. on 2 consecutive days).
Gene_expression (production) of NADPH
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
In recent years, it has become evident that several different forms of the NADPH oxidase exist and comprise a family of related enzymes, which are differentially expressed in a variety of tissue types.
Gene_expression (expressed) of NADPH
12) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.13 Pain Relevance 0.07
with microglia and the assembly of the active microglial NADPH oxidase maybe largely responsible for the oxidative damage observed in the AD brain.


Gene_expression (oxidase) of NADPH in brain associated with disease
13) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.76 Pain Relevance 0.03
The NADPH oxidase consists of two integral membrane proteins, p22phox and gp91phox, which together form a heterodimeric flavoprotein known as cytochrome b558 (Figure 1).
Gene_expression (oxidase) of NADPH
14) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.27 Pain Relevance 0.08
Subsequent studies have substantiated that the NADPH oxidase is essential for A?
Gene_expression (oxidase) of NADPH
15) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.40 Pain Relevance 0.05
Antioxidant therapy and the NADPH oxidase
Gene_expression (oxidase) of NADPH
16) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.71 Pain Relevance 0.04
The NADPH oxidase
Gene_expression (oxidase) of NADPH
17) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.45 Pain Relevance 0.03
-dependent activation of the NADPH oxidase, there is evidence suggesting vitamin E could potentially inhibit an A?
Gene_expression (oxidase) of NADPH
18) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.56 Pain Relevance 0.04
This disease is characterized by a mutation in the genes that encode one of the essential subunits of the NADPH oxidase: p22phox, p47phox, p67phox or gp91phox.
Gene_expression (oxidase) of NADPH associated with disease
19) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.37 Pain Relevance 0.05
Astrocytes and the NADPH oxidase
Gene_expression (oxidase) of NADPH in Astrocytes
20) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.87 Pain Relevance 0.04

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