INT46055

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.91
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
cardiomyocyte 2
neurons 2
brain 2
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 14 100.00 Very High Very High Very High
Versed 10 100.00 Very High Very High Very High
Morphine 27 99.84 Very High Very High Very High
Hippocampus 3 96.32 Very High Very High Very High
narcan 3 95.60 Very High Very High Very High
antagonist 1 95.20 Very High Very High Very High
dexamethasone 1 94.88 High High
opiate 1 94.76 High High
tail-flick 1 93.16 High High
tolerance 8 85.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 42 100.00 Very High Very High Very High
Injury 8 100.00 Very High Very High Very High
Disease 116 98.32 Very High Very High Very High
Death 30 97.76 Very High Very High Very High
Nociception 1 96.52 Very High Very High Very High
Neuroblastoma 4 94.84 High High
Body Weight 3 87.28 High High
Ataxia 1 83.64 Quite High
Neurodegenerative Disease 8 75.80 Quite High
Drug Induced Neurotoxicity 10 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment.
Neg (unaffected) Regulation (unaffected) of Gene_expression (levels) of NADPH dehydrogenase associated with morphine
1) Confidence 0.06 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.18
Abramov and colleagues have examined a potential role for astrocytic NADPH oxidase-derived ROS in fA?
Spec (examined) Regulation (role) of Gene_expression (oxidase) of NADPH
2) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.32 Pain Relevance 0
with microglia and the assembly of the active microglial NADPH oxidase maybe largely responsible for the oxidative damage observed in the AD brain.


Regulation (responsible) of Gene_expression (oxidase) of NADPH in brain associated with disease
3) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.82 Pain Relevance 0.03
Role of NADPH oxidase in lethal toxin-induced superoxide generation and cell death
Regulation (Role) of Gene_expression (oxidase) of NADPH associated with death
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.15 Pain Relevance 0
Role of NADPH oxidase in lethal toxin-induced cardiomyocyte contractile response
Regulation (Role) of Gene_expression (oxidase) of NADPH in cardiomyocyte
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0 Pain Relevance 0
Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively.
Spec (determine) Regulation (effect) of Gene_expression (expression) of NADPH-d associated with versed and morphine
6) Confidence 0.01 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740792 Disease Relevance 0.10 Pain Relevance 1.92
The present study aimed to assess the role of anti-inflammatory drugs in injury-induced production of NADPH-d/NOS in CA1 pyramidal neurones.
Regulation (role) of Gene_expression (production) of NADPH-d associated with inflammation, injury and cinod
7) Confidence 0.01 Published 1994 Journal Neuroreport Section Abstract Doc Link 7827327 Disease Relevance 0.35 Pain Relevance 0.27
RESULTS: Acute administration of naloxone and chronic administration of morphine did not change the expression of Fos protein and NADPH-d positive neurons, and there was no expression of Fos/NADPH-d double-labeled neurons in the spinal cord of rats.
Neg (not) Regulation (change) of Gene_expression (expression) of NADPH-d in neurons
8) Confidence 0.00 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11747755 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox