INT4606

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2011
Negated 12
Speculated 11
Reported most in Body
Documents 67
Total Number 78
Disease Relevance 54.69
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 13
pancreas 4
body 4
adipose tissue 3
embryos 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 232 100.00 Very High Very High Very High
anesthesia 29 100.00 Very High Very High Very High
cINOD 27 100.00 Very High Very High Very High
Catecholamine 24 100.00 Very High Very High Very High
antidepressant 41 99.98 Very High Very High Very High
Somatostatin 6 99.92 Very High Very High Very High
beta blocker 9 99.28 Very High Very High Very High
Pain 136 99.26 Very High Very High Very High
tolerance 202 99.16 Very High Very High Very High
Inflammatory marker 3 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4356 100.00 Very High Very High Very High
Obesity 624 100.00 Very High Very High Very High
Insulin Resistance 422 100.00 Very High Very High Very High
Disease 375 100.00 Very High Very High Very High
INFLAMMATION 260 100.00 Very High Very High Very High
Impaired Glucose Tolerance 213 100.00 Very High Very High Very High
Adhesions 32 100.00 Very High Very High Very High
Cv Unclassified Under Development 28 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 1 100.00 Very High Very High Very High
Hyperglycemia 359 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study seems to indicate that hyperproduction of endogenous opioid peptides in obesity increases insulin secretion stimulated by food intake, whereas it does not appreciably affect insulin production stimulated by circulating glucose or aminoacids.
Neg (not) Regulation (affect) of Gene_expression (production) of insulin associated with obesity and endogenous opioid
1) Confidence 0.61 Published 1989 Journal Int J Obes Section Abstract Doc Link 2529225 Disease Relevance 0.48 Pain Relevance 0.44
The mutations shown in yellow are recessive mutations that affect insulin biosynthesis (mutation of the translation initiation Met) or cause the synthesis of a nonsense protein (Q62X)

Insulin mutations in monogenic forms of diabetes

Regulation (affect) of Gene_expression (biosynthesis) of insulin associated with diabetes mellitus
2) Confidence 0.60 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.99 Pain Relevance 0.04
In addition, insulin resistance may influence not only the lipid levels but also lipid profile patterns, such as the HDL subfraction or the LDL size.28 Thus, there could be changes in the HDL subfraction or the LDL size, and no differences between the lipid levels of the two groups.
Spec (may) Regulation (influence) of Gene_expression (resistance) of insulin associated with insulin resistance and disorder of lipid metabolism
3) Confidence 0.45 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 1.17 Pain Relevance 0
Advantages of insulin detemir in the clinical arena
Regulation (Advantages) of Gene_expression (detemir) of insulin
4) Confidence 0.45 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0.14 Pain Relevance 0.10
Moreover, the tendency among physicians to reserve insulin therapy for those patients who are inadequately controlled with diet and oral antidiabetic agents means that a high proportion of patients receiving insulin will have pre-existing co-morbidities and complications due to longstanding disease (Liebl et al 2002).
Regulation (controlled) of Gene_expression (therapy) of insulin associated with disease
5) Confidence 0.45 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.67 Pain Relevance 0
The majority of these clinical trials reported a similar lack of effect for insulin glargine and NPH insulin on antibody titers.
Regulation (effect) of Gene_expression (glargine) of insulin
6) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.18 Pain Relevance 0
Glycemic control in adults: insulin glargine versus other antidiabetic treatments
Regulation (control) of Gene_expression (glargine) of insulin
7) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.49 Pain Relevance 0
Although there was no difference between the insulin glargine and NPH insulin treatment groups with respect to baseline-to-endpoint change in HbA1c levels, significant reductions in FBG levels were observed with insulin glargine (?
Neg (no) Regulation (difference) of Gene_expression (groups) of NPH insulin
8) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.45 Pain Relevance 0
Although there was no difference between the insulin glargine and NPH insulin treatment groups with respect to baseline-to-endpoint change in HbA1c levels, significant reductions in FBG levels were observed with insulin glargine (?
Neg (no) Regulation (difference) of Gene_expression (glargine) of insulin
9) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.44 Pain Relevance 0
Glycemic control in adults: insulin glargine versus other antidiabetic treatments
Regulation (control) of Gene_expression (glargine) of insulin
10) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.37 Pain Relevance 0
The majority of these clinical trials reported a similar lack of effect for insulin glargine and NPH insulin on antibody titers.
Regulation (effect) of Gene_expression (glargine) of NPH insulin
11) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.18 Pain Relevance 0
Although the subcutaneous insulin infusion is expected to follow
Regulation (expected) of Gene_expression (infusion) of insulin
12) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.19 Pain Relevance 0
For

example, in the intravenous insulin infusion, since the catheter is kept to be

Regulation (kept) of Gene_expression (infusion) of insulin
13) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.39 Pain Relevance 0
moderately in the range of subcutaneous insulin injection to intravenous
Regulation (range) of Gene_expression (injection) of insulin
14) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.71 Pain Relevance 0
dinner and bedtime, a couple of other regular insulin injections are carried
Regulation (regular) of Gene_expression (injections) of insulin
15) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.29 Pain Relevance 0
of its advantages, in the intraperitoneal insulin infusion, external insulin
Regulation (intraperitoneal) of Gene_expression (infusion) of insulin in external
16) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.67 Pain Relevance 0
with the intraperitoneal insulin infusion showed that insulin soaked up from
Regulation (intraperitoneal) of Gene_expression (infusion) of insulin
17) Confidence 0.45 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.74 Pain Relevance 0.06
This observation suggests that behavioral guidance regarding insulin dosing, meals and snacks, and activity levels may be able to lower the risk of hypoglycemia.
Regulation (regarding) of Gene_expression (dosing) of insulin associated with hypoglycemia
18) Confidence 0.45 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350138 Disease Relevance 0.49 Pain Relevance 0
As with the shorter-term trial, insulin glargine was more effective at reducing FPG levels (?
Regulation (effective) of Gene_expression (glargine) of insulin
19) Confidence 0.45 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993975 Disease Relevance 0.39 Pain Relevance 0
Trials evaluating insulin glargine versus NPH insulin added to existing OAD therapy have found that treatment with either agent resulted in similar improvements in glycemic control [23,34,35].
Regulation (evaluating) of Gene_expression (glargine) of insulin
20) Confidence 0.45 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.21 Pain Relevance 0

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