INT46087

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.49
Pain Relevance 0.68

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extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
platelet 2
plasma 1
vasculature 1
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 97.88 Very High Very High Very High
tolerance 1 95.32 Very High Very High Very High
cva 9 93.28 High High
Bioavailability 4 92.96 High High
Pain 4 68.16 Quite High
headache 1 53.68 Quite High
aspirin 2 36.56 Quite Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 98.58 Very High Very High Very High
Congenital Anomalies 2 97.20 Very High Very High Very High
Injury 3 96.08 Very High Very High Very High
Cytomegalovirus Infection 23 96.04 Very High Very High Very High
Cv General 3 Under Development 4 93.28 High High
Systemic Lupus Erythematosus 1 90.56 High High
Hyperhomocysteinemia 15 90.48 High High
Immunization 1 86.96 High High
Stroke 2 85.08 High High
Disseminated Intravascular Coagulation 5 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated partial thromboplastin time, hematocrit, and closure time did not change, whereas PT and platelet count decreased during cooling.
Neg (not) Regulation (change) of thromboplastin in platelet
1) Confidence 0.45 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12761010 Disease Relevance 0.29 Pain Relevance 0.10
Partial thromboplastin time values were obtained at every 4 hr after the start of thrombolytic therapy, and the heparin infusion rate was adjusted to maintain the partial thromboplastin time range with 50-90 sec.
Regulation (values) of thromboplastin
2) Confidence 0.26 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816339 Disease Relevance 0.20 Pain Relevance 0
The s.c. administration of the two Desmin doses had a negligible effect on the activated partial thromboplastin time and a very small effect on the thrombin time, measured with human thrombin; in contrast, Heptest, heparin cofactor II, and anti-Xa activities increased, with a good drug bioavailability (more than 100%).
Spec (partial) Regulation (effect) of thromboplastin associated with bioavailability
3) Confidence 0.23 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352383 Disease Relevance 0 Pain Relevance 0.28
Coagulation abnormalities included elevated fibrin split products, decreased platelet levels and serum fibrinogen levels, and prolonged prothrombin time and partial thromboplastin time values.
Spec (partial) Regulation (values) of thromboplastin in platelet associated with congenital anomalies
4) Confidence 0.14 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6848023 Disease Relevance 0.58 Pain Relevance 0.13
Inhibition of endothelial cell nitric oxide production, enhanced oxidative stress, IL-8 up-regulation leading to enhanced leukocyte recruitment, and up-regulation of tissue factor within the vasculature are among many mechanisms proposed underpinning homocysteine induced cell injury [12-15].
Regulation (regulation) of tissue factor in vasculature associated with stress and injury
5) Confidence 0.06 Published 2009 Journal Thromb J Section Body Doc Link PMC2689184 Disease Relevance 0.87 Pain Relevance 0.04
No pathological values for prothrombin time ratio, activated partial thromboplastin time, plasma antithrombin III, protein C and S activity were found.
Neg (No) Regulation (values) of thromboplastin in plasma
6) Confidence 0.04 Published 2005 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1198216 Disease Relevance 1.56 Pain Relevance 0.14

General Comments

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