INT46088

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 13.70
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
macrophages 2
platelet 2
stroma 1
endothelial cells 1
Plaque 1
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 196 99.92 Very High Very High Very High
cytokine 164 99.40 Very High Very High Very High
Angina 8 99.40 Very High Very High Very High
aspirin 28 98.32 Very High Very High Very High
Inflammatory stimuli 3 95.12 Very High Very High Very High
adenocard 5 92.08 High High
beta blocker 1 84.52 Quite High
cva 112 84.48 Quite High
antagonist 10 83.92 Quite High
anesthesia 2 77.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 514 99.92 Very High Very High Very High
INFLAMMATION 233 99.92 Very High Very High Very High
Disseminated Intravascular Coagulation 16 99.92 Very High Very High Very High
Malignant Neoplastic Disease 54 99.86 Very High Very High Very High
Cv General 3 Under Development 91 99.40 Very High Very High Very High
Injury 36 99.36 Very High Very High Very High
Atherosclerotic Plaque 6 99.32 Very High Very High Very High
Coagulation Disorder 84 99.20 Very High Very High Very High
Adhesions 24 98.90 Very High Very High Very High
Rupture 16 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent mechanism for obstetrically related DIC is release of placental tissue thromboplastin and/or amniotic fluid, which contain a procoagulant, into the maternal venous circulation.
Localization (release) of thromboplastin in amniotic fluid associated with disseminated intravascular coagulation
1) Confidence 0.37 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6848023 Disease Relevance 0.64 Pain Relevance 0.12
1 within the endometrium plays a critical role in triggering the process of menstruation in cells from non-pregnant endometrium by inhibiting biosynthesis and/or secretion of PRL, IGFBP-1 and tissue factor (TF) via a SMAD-dependent pathway.
Localization (secretion) of tissue factor in endometrium
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.17 Pain Relevance 0.03
A dose-dependent prolongation of PT, activated partial thromboplastin time (aPTT), and HepTest to a similar extent to inhibition of FXa were seen, and it was suggested that the inhibition of the FXa activity of rivaroxaban can be monitored by these clotting tests or by measurement of FXa alone (Kubitza 2005a).
Localization (prolongation) of thromboplastin associated with coagulation disorder
3) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.44 Pain Relevance 0.06
An invasive operative procedure cannot be performed without tissue damage resulting in release of tissue factor (TF).
Localization (release) of tissue factor
4) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.07 Pain Relevance 0.03
rFVIIa acts at sites where the endothelium is damaged and tissue factor is released, implying a local mode of action. rFVIIa forms a complex with the tissue factor and then activates factor X and platelets, resulting in the local generation of thrombin and consecutively in the formation of a stable fibrin clot [11].
Localization (released) of tissue factor in endothelium
5) Confidence 0.06 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1876232 Disease Relevance 0.86 Pain Relevance 0.04
Rupture of an atherosclerotic plaque leads to thrombocyte activation, release of tissue thromboplastin and activation of the coagulation system aspirin inhibits platelet function and thus reduces thromboxane A2 formation.
Localization (release) of thromboplastin in platelet associated with aspirin, atherosclerotic plaque and rupture
6) Confidence 0.05 Published 1994 Journal Vnitr Lek Section Abstract Doc Link 8073649 Disease Relevance 1.22 Pain Relevance 0.35
In endothelial cells, CRP increased the expression of vascular cell adhesion molecule (VCAM-1) and intracellular adhesion molecule (ICAM-1), and increased MCP-1 production and tissue factor release [8,21].
Localization (release) of tissue factor in endothelial cells associated with adhesions
7) Confidence 0.04 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.76 Pain Relevance 0.32
In addition, activated macrophages and smooth muscle cells from the exposed necrotic core release tissue factor (TF) leading to activation of the coagulation cascade (Arora and Dhir 2005) and thrombin production (Sciulli and Mauro 2002).
Localization (release) of tissue factor in macrophages
8) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.63 Pain Relevance 0.05
A cell-based model of hemostasis was introduced in 1994, emphasizing the importance of both platelets and tissue factor (TF), an initiator of coagulation, for proper hemostasis.57,58 The coagulation process involves the following 3 phases: initiation, amplification, and propagation.
Localization (importance) of tissue factor in platelets
9) Confidence 0.04 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915535 Disease Relevance 0.64 Pain Relevance 0
Alternatively, the complex of factor VII, calcium, and tissue thromboplastin released from the extrinsic clotting system can also activate factor IX of intrinsic clotting system.
Localization (released) of thromboplastin associated with coagulation disorder
10) Confidence 0.02 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.03 Pain Relevance 0
Similar to normal activated inflammatory cells, malignant cells release tissue factor [75-77] which promotes the formation of fibrin deposits in the tumor cell microenvironment [88-90].
Localization (release) of tissue factor associated with malignant neoplastic disease, inflammation and cancer
11) Confidence 0.02 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 1.82 Pain Relevance 0.32
While the cancer cell continues to act as if it participated in a wound healing process, it actually enlarges the wound stroma due to its constitutive secretion of tissue factor, inflammatory cytokines and other growth factors which also provide stimuli for the propagation of the malignant cells.
Localization (secretion) of tissue factor in stroma associated with malignant neoplastic disease, inflammation, cancer, injury, wound healing and cytokine
12) Confidence 0.02 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 2.12 Pain Relevance 0.28
In response to inflammatory molecules, complement, lymphokines and immune complexes, these cells subsequently secrete procoagulant tissue factor; tumor-associated macrophages express significantly higher levels of tissue factor than control cells [109,110].
Localization (secrete) of tissue factor in macrophages associated with inflammation and cancer
13) Confidence 0.02 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 1.68 Pain Relevance 0.34
Plaque in unstable angina possesses elevated levels of tissue factor that could be released during inflammation, precipitating acute clinical syndromes.
Localization (released) of tissue factor in Plaque associated with angina, inflammation and syndrome
14) Confidence 0.02 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 0.98 Pain Relevance 0.25
In addition, activated macrophages and smooth muscle cells from the exposed necrotic core release tissue factor (TF) leading to activation of the coagulation cascade (Arora and Dhir 2005) and thrombin production (Sciulli and Mauro 2002).
Localization (release) of tissue factor in smooth muscle cells
15) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.63 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox