INT4609

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Context Info
Confidence 0.47
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.81
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klkb1) extracellular space (Klkb1) extracellular region (Klkb1)
molecular_function (Klkb1) cellular_component (Klkb1) biological_process (Klkb1)
Anatomy Link Frequency
plasma 4
brain 1
Klkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 2 99.76 Very High Very High Very High
transdermal 3 99.52 Very High Very High Very High
Dopamine 1 99.46 Very High Very High Very High
Morphine 5 97.28 Very High Very High Very High
tolerance 1 95.28 Very High Very High Very High
Angina 4 88.56 High High
headache 2 62.64 Quite High
Gabapentin 2 50.00 Quite Low
amygdala 1 46.16 Quite Low
Analgesic 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 93.28 High High
Heart Rate Under Development 2 93.12 High High
Increased Venous Pressure Under Development 1 92.04 High High
Myocardial Infarction 1 89.72 High High
Cv General 3 Under Development 4 88.56 High High
Headache 1 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma nitroglycerin levels demonstrated consistently high plasma levels over each 24-hour dosing interval, on day 1, week 1, and week 2.
Gene_expression (levels) of Plasma nitroglycerin in Plasma
1) Confidence 0.47 Published 1989 Journal J Clin Pharmacol Section Abstract Doc Link 2515215 Disease Relevance 0.35 Pain Relevance 0.24
A dose related response was not demonstrated, although low plasma nitroglycerin levels produced significant haemodynamic changes.
Gene_expression (produced) of plasma nitroglycerin in plasma
2) Confidence 0.44 Published 1984 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6428912 Disease Relevance 0.09 Pain Relevance 0.16
CONCLUSION: Plasma gabapentin concentration is unaltered during CPB following preoperative administration.
Gene_expression (concentration) of Plasma gabapentin in Plasma
3) Confidence 0.43 Published 2010 Journal Can J Anaesth Section Body Doc Link 20112079 Disease Relevance 0 Pain Relevance 0
New controlled release transdermal preparations appear to produce constant plasma nitroglycerin concentrations of 0.2-0.3 ng/ml that persist for up to 24 hours.
Gene_expression (produce) of plasma nitroglycerin in plasma associated with transdermal
4) Confidence 0.30 Published 1983 Journal Pharmacotherapy Section Abstract Doc Link 6410359 Disease Relevance 0.36 Pain Relevance 0.14
This study was designed to examine the relationship between regional levels of brain amines (norepinephrine, NE; dopamine, DA; serotonin, 5-HT) and plasma hormone levels (corticosterone, CS; growth hormone, GH) in rats following chronic morphine administration (40 mg/kg twice daily).
Gene_expression (levels) of plasma hormone in brain associated with dopamine, serotonin and morphine
5) Confidence 0.04 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1234768 Disease Relevance 0 Pain Relevance 0.49

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