INT4610

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Context Info
Confidence 0.42
First Reported 1975
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.51
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 2
pituitary 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 10 100.00 Very High Very High Very High
Morphine 11 99.68 Very High Very High Very High
narcan 7 97.36 Very High Very High Very High
Serotonin 7 86.72 High High
Opioid 7 85.36 High High
Dopamine 14 83.68 Quite High
antagonist 40 82.92 Quite High
opiate 1 82.12 Quite High
amygdala 1 76.48 Quite High
Enkephalin 3 75.24 Quite High
Disease Link Frequency Relevance Heat
Starvation 10 90.96 High High
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma CS was found after 1 and 2 weeks of injections and decreased GH levels were present after 2 and 6 weeks.
Negative_regulation (decreased) of Transcription (levels) of GH in plasma
1) Confidence 0.42 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1234768 Disease Relevance 0 Pain Relevance 0.60
Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged.
Negative_regulation (reduction) of Transcription (levels) of GH associated with somatostatin
2) Confidence 0.34 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.29
On the other hand, treatment with morphine produced a 22% decrease in GH mRNA levels, an effect which was prevented by the concomitant administration naloxone.
Negative_regulation (decrease) of Transcription (levels) of GH associated with narcan and morphine
3) Confidence 0.22 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.28
In sheep, treatment with leptin for 1–3 days reduces mRNA levels of GH and GHRH-R in the pituitary, and decreases the GH secretory response to GHRH (449).
Negative_regulation (reduces) of Transcription (levels) of GH in pituitary
4) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.51 Pain Relevance 0

General Comments

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