INT46109
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The ability of AAP to inhibit mitochondrial function and its counteraction by Moutan Cortex was also evaluated. | |||||||||||||||
| |||||||||||||||
|
It is widely accepted that the injury process is initiated by the metabolism of AAP to a reactive metabolite, which first depletes glutathione and then binds to cellular proteins including a number of mitochondrial proteins. | |||||||||||||||
| |||||||||||||||
|
Recognition of the presence of 4-AAP in biological fluids is important, since the parent drug may produce fatal agranulocytosis and the compound may complicate the detection of other compounds that simultaneously partition into the weak-base fraction in toxicology screening. | |||||||||||||||
| |||||||||||||||
|
Thus our unified database and API are very much complementary to the contributions Pathway Commons has done. | |||||||||||||||
| |||||||||||||||
|
Although the experiments were carried out with rats, it is possible to suggest that AAP, ASA or DIP should not interfere with the procedures in nuclear medicine involving the labeling of blood elements with 99mTc. | |||||||||||||||
| |||||||||||||||
|
The next PRESGUID version will use the API modules provided in the VidalĀ® database to check for interactions between drugs recommended in the CPGs and those already administered to patients. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.