INT46109

Context Info Confidence 0.37 First Reported 1983 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.08 Pain Relevance 2.06

extracellular space (SERPINF2) extracellular region (SERPINF2)

Anatomy Link Frequency blood 1 Cortex 1 SERPINF2 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 21 100.00 aspirin 5 100.00 Analgesic 2 96.12 Inflammation 1 95.68 long-term potentiation 7 5.00 nMDA receptor 2 5.00 Pain 1 5.00 Cancer pain 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Injury 4 99.14 Agranulocytosis 1 96.96 INFLAMMATION 1 95.68 Liver Failure 1 89.92 Hepatotoxicity 2 89.00 Overdose 2 87.72 Stress 2 83.92 Toxicity 3 79.24 Parkinson's Disease 2 60.64 Necrosis 1 54.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The ability of AAP to inhibit mitochondrial function and its counteraction by Moutan Cortex was also evaluated.

AAP Binding (counteraction) of in Cortex associated with paracetamol

1) Confidence 0.37 Published 2002 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12419953 Disease Relevance 0.08 Pain Relevance 0.95

It is widely accepted that the injury process is initiated by the metabolism of AAP to a reactive metabolite, which first depletes glutathione and then binds to cellular proteins including a number of mitochondrial proteins.

AAP Binding (binds) of associated with paracetamol and injury

2) Confidence 0.31 Published 2003 Journal Toxicol. Lett. Section Abstract Doc Link 12927346 Disease Relevance 0.81 Pain Relevance 0.44

Recognition of the presence of 4-AAP in biological fluids is important, since the parent drug may produce fatal agranulocytosis and the compound may complicate the detection of other compounds that simultaneously partition into the weak-base fraction in toxicology screening.

4-AAP Binding (presence) of associated with agranulocytosis

3) Confidence 0.31 Published 1983 Journal J Anal Toxicol Section Abstract Doc Link 6855207 Disease Relevance 0.19 Pain Relevance 0.14

Thus our unified database and API are very much complementary to the contributions Pathway Commons has done.

API Binding (complementary) of

4) Confidence 0.29 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

Although the experiments were carried out with rats, it is possible to suggest that AAP, ASA or DIP should not interfere with the procedures in nuclear medicine involving the labeling of blood elements with 99mTc.

AAP Neg (not) Binding (interfere) of in blood associated with aspirin and paracetamol

5) Confidence 0.24 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196202 Disease Relevance 0 Pain Relevance 0.52

The next PRESGUID version will use the API modules provided in the Vidal® database to check for interactions between drugs recommended in the CPGs and those already administered to patients.

API Binding (interactions) of

6) Confidence 0.15 Published 2004 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC375539 Disease Relevance 0 Pain Relevance 0

General Comments

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