INT4611

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Context Info
Confidence 0.68
First Reported 1975
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 1.04
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 4
visceral 1
plasma 1
spinal cord 1
brain stem 1
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 42 100.00 Very High Very High Very High
Morphine 11 99.44 Very High Very High Very High
Spinal cord 12 97.80 Very High Very High Very High
narcan 7 97.36 Very High Very High Very High
Enkephalin 11 96.52 Very High Very High Very High
Opioid 12 94.96 High High
Clonidine 10 93.96 High High
Dorsal horn 6 93.72 High High
Raphe 3 90.12 High High
antagonist 165 87.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 92 94.24 High High
Starvation 40 90.44 High High
Breast Cancer 6 78.64 Quite High
Diphtheria 4 78.00 Quite High
Delayed Puberty 2 76.32 Quite High
Disease 10 36.76 Quite Low
Endometriosis (extended) 6 35.84 Quite Low
Advanced Or Metastatic Breast Cancer 2 35.08 Quite Low
Obesity 16 25.52 Quite Low
Endometrial Cancer 16 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the distribution of GH receptor mRNA to visceral sensory and motor structures is consonant with a role of GH in the regulation of food intake and energy homeostasis.
Transcription (distribution) of GH in visceral
1) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664698 Disease Relevance 0 Pain Relevance 0.45
By using in situ hybridization histochemistry the distribution of growth hormone (GH) receptor mRNA was examined in the rat brain stem and spinal cord.
Transcription (distribution) of GH in spinal cord associated with spinal cord
2) Confidence 0.59 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664698 Disease Relevance 0 Pain Relevance 0.25
GH and SRIF mRNA levels were significantly higher in alpha-FMH-treated pups than in controls, whereas no difference was observed in GHRH mRNA levels.
Transcription (levels) of GH associated with somatostatin
3) Confidence 0.55 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.34
Increased plasma CS was found after 1 and 2 weeks of injections and decreased GH levels were present after 2 and 6 weeks.
Transcription (levels) of GH in plasma
4) Confidence 0.51 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1234768 Disease Relevance 0 Pain Relevance 0.60
Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged.
Transcription (levels) of GH associated with somatostatin
5) Confidence 0.42 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.28
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Transcription (levels) of GH in pituitary associated with somatostatin
6) Confidence 0.37 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.30
In these rats, pituitary GH content and mRNA levels were also significantly increased, whereas hypothalamic SS content and mRNA levels remained unaltered.
Transcription (levels) of GH in pituitary associated with somatostatin
7) Confidence 0.30 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.93
On the other hand, treatment with morphine produced a 22% decrease in GH mRNA levels, an effect which was prevented by the concomitant administration naloxone.
Transcription (levels) of GH associated with narcan and morphine
8) Confidence 0.27 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.28
By using in situ hybridization histochemistry the distribution of growth hormone (GH) receptor mRNA was examined in the rat brain stem and spinal cord.
Transcription (distribution) of GH in brain stem associated with spinal cord
9) Confidence 0.20 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664698 Disease Relevance 0 Pain Relevance 0.25
In this study we examined the effects of these compounds on the mRNA levels of the GH receptor/GH binding protein, IGF-I, ER?
Transcription (levels) of GH
10) Confidence 0.09 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.20 Pain Relevance 0.16
In sheep, treatment with leptin for 1–3 days reduces mRNA levels of GH and GHRH-R in the pituitary, and decreases the GH secretory response to GHRH (449).
Transcription (levels) of GH in pituitary
11) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.51 Pain Relevance 0
Conversely, the total number of cells expressing GH mRNA was significantly reduced by GnRH (117).
Transcription (expressing) of GH
12) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
We studied the effects on mRNA levels of the growth hormone (GH) receptor, insulin-like growth factor-I (IGF-I), ER?
Transcription (levels) of GH
13) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC156658 Disease Relevance 0.08 Pain Relevance 0.04
However, there was no change seen in the number and size of GH cells or GH mRNA level.
Transcription (level) of GH
14) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.25 Pain Relevance 0
Other investigators also found N-POMC increases PRL and GH mRNA expression and stimulates PRL and GH secretion (after 12 h of treatment) in frog pituitary cell cultures (165).
Transcription (expression) of GH in pituitary
15) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09

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