INT46112

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Context Info
Confidence 0.52
First Reported 1983
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 15
Total Number 24
Disease Relevance 11.09
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
striatum 2
pallidum 2
cleavage 1
brain 1
Epithelium 1
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 406 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
Gabapentin 14 99.98 Very High Very High Very High
Glutamate 40 99.40 Very High Very High Very High
spinal dorsal horn 1 99.20 Very High Very High Very High
GABAergic 304 99.04 Very High Very High Very High
pregabalin 78 98.96 Very High Very High Very High
Pain 30 96.08 Very High Very High Very High
Dorsal horn 3 95.40 Very High Very High Very High
antagonist 34 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 181 100.00 Very High Very High Very High
Nicotine Addiction 344 99.80 Very High Very High Very High
Aging 23 99.68 Very High Very High Very High
Disease 26 99.40 Very High Very High Very High
Anxiety Disorder 87 99.28 Very High Very High Very High
Depression 39 98.40 Very High Very High Very High
Pain 30 96.08 Very High Very High Very High
Metaplasia 15 96.04 Very High Very High Very High
Apoptosis 1 95.84 Very High Very High Very High
Dyskinesias 16 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, GAD can also be regulated at the post-translational level by protein phosphorylation, palmitoylation and cleavage [39].
Regulation (regulated) of GAD in cleavage associated with generalized anxiety disorder
1) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.76 Pain Relevance 0.42
We have examined the effects of these long-term haloperidol treatments on the levels of mRNA encoding glutamic acid decarboxylase (GAD, M(r) 67,000), the rate-limiting enzyme of GABA synthesis, in the striatum and pallidum of adult rats.
Spec (examined) Regulation (effects) of glutamic acid decarboxylase in pallidum associated with gaba and generalized anxiety disorder
2) Confidence 0.45 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.41 Pain Relevance 0.05
We have examined the effects of these long-term haloperidol treatments on the levels of mRNA encoding glutamic acid decarboxylase (GAD, M(r) 67,000), the rate-limiting enzyme of GABA synthesis, in the striatum and pallidum of adult rats.
Spec (examined) Regulation (effects) of GAD in pallidum associated with gaba and generalized anxiety disorder
3) Confidence 0.45 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.41 Pain Relevance 0.05
These mice express enhanced green fluorescent protein (eGFP) under the control of the mouse Gad1 gene promoter, thereby revealing the GABA neurons [21].
Regulation (control) of Gad1 in neurons associated with gaba
4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.22 Pain Relevance 0.05
In the absence of research indicating reliable risk factors for the onset of anxiety, and given that our sample was selected on the basis of symptoms, our approach for this trial is to offer a preventative program that included components found effective for both the treatment of GAD, and in the prevention of GAD.
Regulation (effective) of GAD associated with generalized anxiety disorder and anxiety disorder
5) Confidence 0.39 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2848219 Disease Relevance 0.79 Pain Relevance 0.06
In addition, we showed that GAD67 mRNA levels did not change during aging and PD.
Neg (not) Regulation (change) of GAD67 associated with aging and disease
6) Confidence 0.39 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17203488 Disease Relevance 0.76 Pain Relevance 0.20
Further analyses showed no differences in mRNA levels, for pENK, pDYN, or GAD67 mRNA, between PD patients and aged matched controls.
Neg (no) Regulation (differences) of GAD67 associated with disease
7) Confidence 0.39 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17203488 Disease Relevance 0.78 Pain Relevance 0.20
As of February 2010, there were no registered randomised controlled trials examining the effectiveness of online CBT treatments for GAD in young adults.
Spec (examining) Regulation (effectiveness) of GAD associated with generalized anxiety disorder
8) Confidence 0.39 Published 2010 Journal Trials Section Body Doc Link PMC2878300 Disease Relevance 0.27 Pain Relevance 0
Up-regulation of GAD67 in Large and Small Airway Epithelium of Healthy Smokers
Regulation (regulation) of GAD67 in Epithelium associated with nicotine addiction
9) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.52 Pain Relevance 0.43
In vitro, gabapentin modulates the action of the GABA synthetic enzyme, glutamic acid decarboxylase (GAD) and the glutamate synthesizing enzyme, branched-chain amino acid transaminase.
Regulation (modulates) of glutamic acid decarboxylase associated with glutamate, gaba, generalized anxiety disorder and gabapentin
10) Confidence 0.34 Published 1997 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 9686247 Disease Relevance 0.63 Pain Relevance 1.50
GAD is the only enzyme responsible for the irreversible conversion of L-glutamic acid to GABA.
Regulation (responsible) of GAD associated with gaba and generalized anxiety disorder
11) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566591 Disease Relevance 0.85 Pain Relevance 0.97
The expression patterns for individual proteins can be characterized as either no change (GAD67, GABAA?
Neg (no) Regulation (change) of GAD67
12) Confidence 0.28 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.09 Pain Relevance 0.36
Further studies on the role of calcium in the regulation of glutamate decarboxylase activity in brain slices.

[3H]GABA synthesis in brain slices was used as a model to study the role of Ca2+ in the regulation of GAD activity.

Regulation (regulation) of GAD in brain associated with gaba, glutamate and generalized anxiety disorder
13) Confidence 0.27 Published 1983 Journal Neurochem. Res. Section Title Doc Link 6856025 Disease Relevance 0.18 Pain Relevance 0.31
Pohl and colleagues (2005) compared multiple pregabalin dosing regimens (100 mg bid, 200 mg bid, 150 mg tid) in a double-blind, placebo-controlled trial in GAD and found that all three pregabalin groups had improvement in HAM-A scores compared with placebo.
Regulation (controlled) of GAD associated with pregabalin and generalized anxiety disorder
14) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654629 Disease Relevance 0.17 Pain Relevance 0.99
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Regulation (Alterations) of GAD67 in putamen associated with enkephalin and disease
15) Confidence 0.23 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.56 Pain Relevance 0.39
Since decreased cholesterol biosynthesis is associated with increased LDL-receptor expression in hepatocytes [8,9], SCP effects on serum LDL-C can be suggested as originating from increased LDL- binding, uptake or degradation, as demonstrated in studies measuring radiolabeled LDL on the surface of human fibroblasts [5].
Regulation (effects) of SCP in fibroblasts
16) Confidence 0.23 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2390548 Disease Relevance 0 Pain Relevance 0
Based on the observations in the present study, there may be a therapeutic advantage to use GAD67 as a pharmacologic target for smoking-related disorders in the lung.
Regulation (target) of GAD67 in lung associated with nicotine addiction
17) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.60 Pain Relevance 0.52
Together, these findings suggest that cigarette smoking may have a complicated effect on GAD activity.


Regulation (effect) of GAD associated with nicotine addiction and generalized anxiety disorder
18) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.79 Pain Relevance 0.51
Of all of the GABAergic system genes expressed in the large and small airways, only GAD67 was significantly changed >2-fold in healthy smokers compared to healthy nonsmokers (Figure 3A, B).
Regulation (changed) of GAD67 associated with nicotine addiction and gabaergic
19) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.55 Pain Relevance 0.35
We have examined the effects of these long-term haloperidol treatments on the levels of mRNA encoding glutamic acid decarboxylase (GAD, M(r) 67,000), the rate-limiting enzyme of GABA synthesis, in the striatum and pallidum of adult rats.
Spec (examined) Regulation (effects) of GAD in striatum associated with gaba and generalized anxiety disorder
20) Confidence 0.15 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.41 Pain Relevance 0.05

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