INT4612

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Context Info
Confidence 0.64
First Reported 1975
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 64
Total Number 68
Disease Relevance 8.51
Pain Relevance 22.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
pituitary 8
ovary 4
plasma 2
spinal cord 2
nucleus 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 159 100.00 Very High Very High Very High
Dynorphin 55 100.00 Very High Very High Very High
Opioid 51 100.00 Very High Very High Very High
opiate 32 100.00 Very High Very High Very High
Endogenous opioid 25 100.00 Very High Very High Very High
agonist 63 99.98 Very High Very High Very High
Catecholamine 6 99.98 Very High Very High Very High
opioid receptor 16 99.92 Very High Very High Very High
Spinal cord 2 99.84 Very High Very High Very High
antagonist 114 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Precocious Puberty 7 100.00 Very High Very High Very High
Reprotox - General 1 24 99.84 Very High Very High Very High
Stress 22 99.44 Very High Very High Very High
Polycystic Ovary Syndrome 43 99.42 Very High Very High Very High
Syndrome 5 99.32 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 31 98.92 Very High Very High Very High
Delayed Puberty 3 98.88 Very High Very High Very High
Renal Failure 1 98.52 Very High Very High Very High
Hot Flashes 7 98.12 Very High Very High Very High
Cancer 4 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase.
Positive_regulation (augment) of Localization (secretion) of luteinizing hormone associated with catecholamine, narcan and opioid
1) Confidence 0.64 Published 1993 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 7903508 Disease Relevance 0 Pain Relevance 0.34
However, upon stopping the prolonged opiate administration there was a substantial increase in hCG secretion.
Positive_regulation (increase) of Localization (secretion) of hCG associated with opiate
2) Confidence 0.57 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.78
This was followed by a delayed increase in hCG secretion.
Positive_regulation (increase) of Localization (secretion) of hCG
3) Confidence 0.57 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.81
Prolonged administration (90 min) caused an initial increase in pulsatile hCG secretion which was followed by a decrease to control values.
Positive_regulation (increase) of Localization (secretion) of hCG
4) Confidence 0.57 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.71
The results have shown that morphine (100 nM) significantly stimulated hCG secretion by 6-8 weeks old trophoblast and was without effect on hPL.
Positive_regulation (stimulated) of Localization (secretion) of hCG associated with morphine
5) Confidence 0.52 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.69
Isosmotical replacement of extracellular Na+ ([Na+]o) by K+, choline and to a lesser extent by saccharose stimulated the release of chorionic gonadotrophin and placental lactogen from human term placental explants.
Positive_regulation (stimulated) of Localization (release) of chorionic gonadotrophin
6) Confidence 0.45 Published 1994 Journal Placenta Section Abstract Doc Link 7997448 Disease Relevance 0 Pain Relevance 0.07
GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue.
Positive_regulation (stimulation) of Localization (release) of hCG associated with antagonist and opioid
7) Confidence 0.43 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.77
CONCLUSION: Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase in normal cycling women.


Positive_regulation (augment) of Localization (secretion) of luteinizing hormone
8) Confidence 0.43 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 7903508 Disease Relevance 0 Pain Relevance 0
Furthermore, des-tyrosine-DYN, the nonopioid derivative of DYN was 1000 times less potent in stimulating hCG release than DYN.
Positive_regulation (stimulating) of Localization (release) of hCG associated with dynorphin
9) Confidence 0.41 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.79
In superfusion, co-perfusion with embryonic spinal cord tissue increased HCG secretion as opposed to that seen in similar incubations made with embryonic spinal cord tissue obtained from healthy women.
Positive_regulation (increased) of Localization (secretion) of HCG in spinal cord associated with spinal cord
10) Confidence 0.41 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1587933 Disease Relevance 0.08 Pain Relevance 0.10
In the Gn-RH test the gonadotropin secretion was maximally decelerated in hemodialysis patients while it was normal in recipients.
Positive_regulation (decelerated) of Localization (secretion) of gonadotropin
11) Confidence 0.39 Published 1996 Journal Ren Fail Section Abstract Doc Link 8948525 Disease Relevance 0.25 Pain Relevance 0.06
The involvement of opioid receptors in mediating the effect of DYN on hCG release was demonstrated by using naloxone, an opioid receptor antagonist.
Positive_regulation (mediating) of Localization (release) of hCG associated with dynorphin, antagonist, narcan and opioid receptor
12) Confidence 0.38 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.81
Data obtained indicate that opiate agonists stimulate in vitro basal hCG release from trophoblast tissue.
Positive_regulation (stimulate) of Localization (release) of hCG associated with agonist and opiate
13) Confidence 0.38 Published 1991 Journal Life Sci. Section Abstract Doc Link 1652048 Disease Relevance 0 Pain Relevance 0.85
Data presented demonstrated that the stimulation of hCG secretion by the kappa-selective agonist U69,593 was abolished in presence of either EGTA or the calcium channel blocker nifedipine.
Positive_regulation (stimulation) of Localization (secretion) of hCG associated with calcium channel and agonist
14) Confidence 0.36 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 9770647 Disease Relevance 0 Pain Relevance 0.47
Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion.
Positive_regulation (causing) of Localization (release) of hCG associated with mu agonist
15) Confidence 0.29 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.75
Before treatment, both the circulating levels of estrogens and plasma gonadotropins were in the normal range for postmenopausal women and naloxone infusion did not induce any significant modification of gonadotropin secretion.
Neg (not) Positive_regulation (induce) of Localization (secretion) of gonadotropin in plasma associated with narcan
16) Confidence 0.25 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6087184 Disease Relevance 0.09 Pain Relevance 0.45
NE (5 micrograms/ml) enhanced hCG secretion significantly from the second day of treatment.
Positive_regulation (enhanced) of Localization (secretion) of hCG
17) Confidence 0.21 Published 1993 Journal Placenta Section Abstract Doc Link 8153089 Disease Relevance 0 Pain Relevance 0.21
Both the protein kinase C (PKC) specific activator 1-deoyl-2-acetyl-sn-glycerol (OAG) and the PKC non-specific activator phorbol-12-myristate-13-acetate (PMA) had a stimulatory effect on hCG secretion, while the PKC inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H7) diminished the hCG secretion stimulated by NE.
Positive_regulation (effect) of Localization (secretion) of hCG associated with kinase c
18) Confidence 0.21 Published 1993 Journal Placenta Section Abstract Doc Link 8153089 Disease Relevance 0 Pain Relevance 0.58
Both the protein kinase C (PKC) specific activator 1-deoyl-2-acetyl-sn-glycerol (OAG) and the PKC non-specific activator phorbol-12-myristate-13-acetate (PMA) had a stimulatory effect on hCG secretion, while the PKC inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H7) diminished the hCG secretion stimulated by NE.
Positive_regulation (stimulated) of Localization (secretion) of hCG associated with kinase c
19) Confidence 0.21 Published 1993 Journal Placenta Section Abstract Doc Link 8153089 Disease Relevance 0 Pain Relevance 0.62
The secretion of hCG increases during the first trimester in geometrical progression, reaching a maximum at about 10 weeks of gestation.
Positive_regulation (increases) of Localization (secretion) of hCG
20) Confidence 0.19 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.80 Pain Relevance 0.04

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