INT46121

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.84
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1) response to stress (SERPINH1)
Anatomy Link Frequency
erythrocyte 3
superior 1
T cell 1
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 57 100.00 Very High Very High Very High
Arthritis 42 100.00 Very High Very High Very High
Inflammatory response 4 100.00 Very High Very High Very High
abatacept 242 99.98 Very High Very High Very High
Inflammation 107 99.72 Very High Very High Very High
chemokine 13 99.36 Very High Very High Very High
Adalimumab 83 99.24 Very High Very High Very High
methotrexate 104 99.18 Very High Very High Very High
Acupuncture 130 97.88 Very High Very High Very High
corticosteroid 42 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 120 100.00 Very High Very High Very High
Infection 49 100.00 Very High Very High Very High
Experimental Arthritis 13 100.00 Very High Very High Very High
Shock 1 99.74 Very High Very High Very High
Autoimmune Disease 16 99.54 Very High Very High Very High
Cancer 79 99.16 Very High Very High Very High
Arthritis 34 99.14 Very High Very High Very High
Rheumatoid Arthritis 338 97.08 Very High Very High Very High
Syndrome 123 96.08 Very High Very High Very High
Necrosis 23 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both heat-shock protein 47 (HSP47) and OPCML map to 11q (11q13.5 and 11q25 respectively) and chromosome 11q allele loss is frequent in both tumour types (Yokogoshi et al. 1990, Sun et al. 2006, George et al. 2007).
Negative_regulation (loss) of HSP47 associated with cancer and shock
1) Confidence 0.38 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.89 Pain Relevance 0
Several investigators observed that antibiotics reduced the incidence of intrauterine infection after PPROM, demonstrated the prolongation of gestation, and a decrease in the rate of neonatal complications (4, 16-25).
Negative_regulation (reduced) of PPROM associated with infection
2) Confidence 0.31 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808584 Disease Relevance 0.93 Pain Relevance 0.34
As compared with 'Late, KCl' group, 'Early, non-KCl' group was superior in terms of immediate loss, pregnancy loss, take-home-baby, and PPROM rates.
Negative_regulation (loss) of PPROM in superior
3) Confidence 0.13 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526504 Disease Relevance 0.09 Pain Relevance 0
Many of them have already obtained opportunities for drinking relatively safe water containing reduced levels of arsenic provided by the several government and non-governmental organizations in the arseniasis-endemic areas in Bangladesh.
Negative_regulation (reduced) of arsenic
4) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.34 Pain Relevance 0.04
Five previous studies had examined acupuncture for potential anti-inflammatory effects [10,11,22,28], only one showed an anti-inflammatory effects with decreased rheumatoid factor, IgA, IgG levels, and decreased T cell activity with no change in ESR [29].
Negative_regulation (decreased) of rheumatoid factor in T cell associated with inflammation and acupuncture
5) Confidence 0.01 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2174514 Disease Relevance 0.49 Pain Relevance 0.64
Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study

Studies on autoantibody production in patients treated with tumor necrosis factor-?

Negative_regulation (reduction) of rheumatoid factor associated with necrosis, cancer and adalimumab
6) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526573 Disease Relevance 0.53 Pain Relevance 0.36
No reliable markers predictive for the clinical response have been identified, although a recent report suggests that a decrease in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody titers might be a useful adjunct in assessing the efficacy of treatment [6].
Negative_regulation (decrease) of rheumatoid factor
7) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.55 Pain Relevance 0.23
The investigations were limited to exclusion of known autoimmune diseases, by demonstrating the absence of the more common autoantibodies, such as anti-nuclear antibodies (ANA) and rheumatoid factor (RF).
Negative_regulation (absence) of rheumatoid factor associated with autoimmune disease
8) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.64 Pain Relevance 0.16
At the doses of 2 mg/kg or 10 mg/kg used in further clinical studies, abatacept decreased serum levels of proinflammatory cytokines and inflammatory responses, including soluble IL-2 receptor, IL-6, E-selectin, TNF-alfa, rheumatoid factor, and C-reactive protein levels (Weisman et al. 2006).
Negative_regulation (decreased) of rheumatoid factor associated with inflammatory response, abatacept and cytokine
9) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.54 Pain Relevance 0.65
Patients in the rituximab groups experienced substantial and rapid reductions in rheumatoid factor levels, whereas those in the methotrexate alone group experienced only a moderate reduction in rheumatoid factor levels [5] (Fig. 2).


Negative_regulation (reduction) of rheumatoid factor associated with methotrexate
10) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833972 Disease Relevance 1.16 Pain Relevance 0.24
In support of a pro-inflammatory role in arthritis, neutralizing antibodies against IL-27p28 suppress experimental arthritis [67].


Negative_regulation (suppress) of arthritis associated with inflammation, experimental arthritis and arthritis
11) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.20 Pain Relevance 0.84
METHODS: Sixty patients with seropositive RA for rheumatoid factor and 74 patients with seronegative RA involving the TMJ were investigated regarding synovial fluid and plasma levels of IL-1sRII, 5-HT, and TNF as well as erythrocyte sedimentation rate, C-reactive protein, thrombocyte particle count, and rheumatoid factor in blood.
Spec (investigated) Negative_regulation (regarding) of rheumatoid factor in erythrocyte
12) Confidence 0.00 Published 2008 Journal J Orofac Pain Section Body Doc Link 18780536 Disease Relevance 0.37 Pain Relevance 0
Evaluation of biomarkers in patients recruited as part of the AIM and ATTAIN studies confirmed an effective cellular action [42]; specifically, reductions in rheumatoid factor, CRP, soluble IL-2 receptor, IL-6, TNF-?
Negative_regulation (reductions) of rheumatoid factor
13) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.15 Pain Relevance 0.40
In the group of 7 patients who showed clinical improvement there were significant reductions in serum levels of rheumatoid factor, C-reactive protein, alpha 1-antitrypsin, IgA, IgM and IgE, as well as in erythrocyte sedimentation rates.
Negative_regulation (reductions) of rheumatoid factor in erythrocyte
14) Confidence 0.00 Published 1983 Journal S. Afr. Med. J. Section Abstract Doc Link 6857416 Disease Relevance 0.50 Pain Relevance 0.17
In addition, it decreased C-reactive protein, rheumatoid factor, and the erythrocyte sedimentation rate, changes that were not seen during treatment with non-steroidal anti-inflammatory drugs.
Negative_regulation (decreased) of rheumatoid factor in erythrocyte associated with inflammation and cinod
15) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 1.47 Pain Relevance 0.34

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