INT4613

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Context Info
Confidence 0.67
First Reported 1975
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 32
Total Number 38
Disease Relevance 18.19
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neuronal 1
liver 1
muscle 1
adipose tissue 1
optic 1
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 238 99.54 Very High Very High Very High
electroacupuncture 492 98.76 Very High Very High Very High
Morphine 28 98.54 Very High Very High Very High
cINOD 45 96.88 Very High Very High Very High
Neuritis 6 95.40 Very High Very High Very High
agonist 59 94.48 High High
Acupuncture 60 94.24 High High
Multiple sclerosis 128 88.40 High High
Demyelination 24 87.48 High High
Hippocampus 25 83.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 268 99.54 Very High Very High Very High
Diabetes Mellitus 147 99.52 Very High Very High Very High
Lifespan 86 99.44 Very High Very High Very High
Syndrome 24 99.36 Very High Very High Very High
Stress 98 99.28 Very High Very High Very High
Insulin Resistance 177 99.26 Very High Very High Very High
Metabolic Disorder 6 97.96 Very High Very High Very High
Burns 5 97.96 Very High Very High Very High
Death 155 97.94 Very High Very High Very High
Obesity 236 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This active form of CYB5R3
                       would increase NADH oxidation and release NAD+ that, in turn, would
                       activate SIRT1. 
Positive_regulation (activate) of SIRT1
1) Confidence 0.67 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0 Pain Relevance 0
Meanwhile, electric stimulation such as exercise induces muscle contraction, which has been observed to activate SIRT1/PGC-1?
Positive_regulation (activate) of SIRT1 in muscle
2) Confidence 0.66 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.71 Pain Relevance 0.37
Collectively, these studies support the possibility that EA improves insulin sensitivity, at least partially, because of increasing SIRT1/PGC-1?
Positive_regulation (increasing) of SIRT1 associated with electroacupuncture
3) Confidence 0.66 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.15
SIRT1 levels may increase in rodent and human tissues in response to calorie restriction and exercise [2].
Spec (may) Positive_regulation (increase) of SIRT1
4) Confidence 0.66 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.35 Pain Relevance 0.45
Finally, we have observed that resveratrol 3- and 4'-O-sulfate metabolites activate SIRT1 equipotently to resveratrol, but that activation is probably a substrate-dependent phenomenon with little in vivo relevance.
Positive_regulation (activate) of SIRT1
5) Confidence 0.65 Published 2010 Journal Biochem. J. Section Abstract Doc Link 20450491 Disease Relevance 0.15 Pain Relevance 0.19
Chen and co-workers (2005) showed that by activating SIRT-1, resveratrol inhibited, indirectly, nuclear factor ?
Positive_regulation (activating) of SIRT-1
6) Confidence 0.63 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 1.10 Pain Relevance 0.04
Recent report showed that this assay was not suitable to direct measurement of the SIRT1 activity and that resveratrol did not activate SIRT1 in the assay without the fluorophore-containing peptide [26].
Neg (not) Positive_regulation (activate) of SIRT1
7) Confidence 0.59 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.22 Pain Relevance 0
Vaticanol C did not activate SIRT1 whereas resveratrol activated SIRT1 by the assay utilizing a fluorophore-containing peptide (Figure 2C).
Positive_regulation (activated) of SIRT1
8) Confidence 0.59 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.27 Pain Relevance 0
Vaticanol C did not activate SIRT1 whereas resveratrol activated SIRT1 by the assay utilizing a fluorophore-containing peptide (Figure 2C).
Neg (not) Positive_regulation (activate) of SIRT1
9) Confidence 0.59 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.22 Pain Relevance 0
A nutrient signaling response mediated by pyruvate induces Sirt1 protein in liver during fasting, where it interacts with and deacetylates PGC-1?
Positive_regulation (induces) of Sirt1 protein in liver
10) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.44 Pain Relevance 0
Activation of SIRT1 using other non-commercially available compounds has also been reported to be neuroprotective in a model of optic neuritis [22].
Positive_regulation (Activation) of SIRT1 in optic associated with optic neuritis and neuritis
11) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.91 Pain Relevance 0.10
Conditions of high NADH
                       would lead to partial inactivation of SIRT1, leading to an accumulation
                       of the acetylated form of CYB5R3. 
Spec (partial) Positive_regulation (inactivation) of SIRT1
12) Confidence 0.49 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0 Pain Relevance 0
Resveratrol mimics caloric restriction by extending the lifespan of different organisms via activation of deacetylases from the sirtuin family [36].
Positive_regulation (activation) of sirtuin associated with lifespan
13) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.73 Pain Relevance 0.03
Likewise, another study found that resveratrol is not a general activator of Sir2 and that activation requires the presence of a covalently bound fluorophore (Borra et al 2005).
Neg (not) Positive_regulation (activator) of Sir2
14) Confidence 0.46 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.61 Pain Relevance 0
(p<0.01) and a marginal increase in Sirt-1 and Sirt-3 as compared to the ob/ob group, although in the case of the sirtuins differences were not statistically significant.
Positive_regulation (increase) of Sirt-1
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.75 Pain Relevance 0
Indeed, activation of SIRT1 has been implicated as potential therapy to protect against insulin resistance [6, 32].
Positive_regulation (activation) of SIRT1 associated with insulin resistance
16) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.38 Pain Relevance 0.38
Specifically, low-frequency EA improved insulin sensitivity in a mouse model of genetic insulin resistance and diabetes, at least in part, via stimulation of SIRT1/PGC-1?
Positive_regulation (stimulation) of SIRT1 associated with diabetes mellitus, insulin resistance and electroacupuncture
17) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.69 Pain Relevance 0.31
Taken collectively, these findings implicate SIRT1 activation as a potential therapeutic target in overcoming insulin resistance.
Positive_regulation (activation) of SIRT1 associated with insulin resistance
18) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.13 Pain Relevance 0.07
A reduction in core body temperature is associated with reduced energy expenditure and improved survival in mice, and vice versa (Conti et al 2006), yet the increased fat metabolism by the mitochondria-rich brown fat, leading to more adipose tissue burn off, suggests that the higher dose of resveratrol used in the Auwerx study was sufficient to trigger SIRT-1 activation (Koo and Montminy 2006).
Positive_regulation (activation) of SIRT-1 in adipose tissue associated with burns and obesity
19) Confidence 0.43 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.54 Pain Relevance 0.03
Because resveratrol has been reported to be an activator for SIRT1 [13], we evaluated the activation of SIRT1 by ?
Positive_regulation (activation) of SIRT1
20) Confidence 0.40 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.12 Pain Relevance 0.04

General Comments

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